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Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha.
Biochem Biophys Res Commun. 2000 Nov 11; 278(1):250-7.BB

Abstract

The peroxisome proliferator-activated receptor alpha (PPAR alpha) is a nuclear receptor that transcriptionally regulates mitochondrial and peroxisomal fatty acid beta-oxidation enzymes in the liver. Ligands include synthetic peroxisome proliferators and some fatty acids. PPARalpha activation leads to predictable pleiotropic responses in liver including peroxisome proliferation, increased fatty acid oxidation, and hepatocellular carcinoma. In the current study, the response to PPAR alpha-activation was compared in the heart, kidney, and liver since the role of PPAR alpha in extrahepatic fatty acid-oxidizing organs has not been fully explored. Basal expression of mitochondrial beta-oxidation enzymes was comparable in the three tissues, but peroxisomal beta-oxidation enzymes were most abundant in the liver and less so in the kidney and especially in the heart. After PPAR alpha activation with ciprofibrate, both mitochondrial and peroxisomal beta-oxidation enzymes were induced, with the strongest response seen in the liver, a moderate response in the kidney, and no significant response in the heart. PPAR alpha mRNA analysis suggested that the differential response may be related to PPAR alpha expression.

Authors+Show Affiliations

Department of Pathology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611-3008, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11071880

Citation

Cook, W S., et al. "Less Extrahepatic Induction of Fatty Acid Beta-oxidation Enzymes By PPAR Alpha." Biochemical and Biophysical Research Communications, vol. 278, no. 1, 2000, pp. 250-7.
Cook WS, Yeldandi AV, Rao MS, et al. Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha. Biochem Biophys Res Commun. 2000;278(1):250-7.
Cook, W. S., Yeldandi, A. V., Rao, M. S., Hashimoto, T., & Reddy, J. K. (2000). Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha. Biochemical and Biophysical Research Communications, 278(1), 250-7.
Cook WS, et al. Less Extrahepatic Induction of Fatty Acid Beta-oxidation Enzymes By PPAR Alpha. Biochem Biophys Res Commun. 2000 Nov 11;278(1):250-7. PubMed PMID: 11071880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha. AU - Cook,W S, AU - Yeldandi,A V, AU - Rao,M S, AU - Hashimoto,T, AU - Reddy,J K, PY - 2000/11/10/pubmed PY - 2001/2/28/medline PY - 2000/11/10/entrez SP - 250 EP - 7 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 278 IS - 1 N2 - The peroxisome proliferator-activated receptor alpha (PPAR alpha) is a nuclear receptor that transcriptionally regulates mitochondrial and peroxisomal fatty acid beta-oxidation enzymes in the liver. Ligands include synthetic peroxisome proliferators and some fatty acids. PPARalpha activation leads to predictable pleiotropic responses in liver including peroxisome proliferation, increased fatty acid oxidation, and hepatocellular carcinoma. In the current study, the response to PPAR alpha-activation was compared in the heart, kidney, and liver since the role of PPAR alpha in extrahepatic fatty acid-oxidizing organs has not been fully explored. Basal expression of mitochondrial beta-oxidation enzymes was comparable in the three tissues, but peroxisomal beta-oxidation enzymes were most abundant in the liver and less so in the kidney and especially in the heart. After PPAR alpha activation with ciprofibrate, both mitochondrial and peroxisomal beta-oxidation enzymes were induced, with the strongest response seen in the liver, a moderate response in the kidney, and no significant response in the heart. PPAR alpha mRNA analysis suggested that the differential response may be related to PPAR alpha expression. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/11071880/Less_extrahepatic_induction_of_fatty_acid_beta_oxidation_enzymes_by_PPAR_alpha_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(00)93739-2 DB - PRIME DP - Unbound Medicine ER -