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Hormonal levels among HIV-1-seropositive women compared with high-risk HIV-seronegative women during the menstrual cycle. Women's Health Study (WHS) 001 and WHS 001a Study Team.
J Womens Health Gend Based Med 2000; 9(8):857-63JW

Abstract

There is a paucity of normative data on hormonal levels among HIV-infected women. Hormonal levels may influence fertility and HIV-related immunological and virological factors. The objective of this study was to determine progesterone and estradiol levels during the menstrual cycle in HIV-seropositive women compared with high-risk seronegative women. The study enrolled 55 HIV-infected and 10 high-risk uninfected women with self-reported regular menstrual cycles (25-30-day cycles). Progesterone and estradiol levels were determined on a weekly basis for 8 weeks. The analysis included evaluations from the first complete menstrual cycle for the 54 HIV-infected and 9 uninfected women who had at least one complete cycle. The median age was 35 years for HIV-infected women and 36 years for uninfected women. The median CD4+ count for HIV-seropositive women was 210 cells/mm3. The median menstrual cycle length was 28 days (range 22-49 days) for HIV-infected women and 25 days (range 24-44 days) for uninfected women. The maximum progesterone level during the luteal phase was normal (>3.0 ng/ml) for 52 (96%) of 54 HIV-seropositive women and 7 (78%) of 9 HIV-seronegative women (p = 0.09, Fisher's exact test). The median maximum progesterone level was 12.2 ng/ml in HIV-seropositive women and 7.2 ng/ml in HIV-seronegative women (p = 0.07, Wilcoxon test). The median maximum estradiol value during the follicular phase was 148 pg/ml for HIV-seropositive women and 111 pg/ml for HIV-seronegative women (p = 0.04, Wilcoxon test). Among HIV-infected women, there were no significant differences in progesterone and estradiol levels by antiretroviral therapy, baseline plasma viral load, or median CD4+ cell count. We conclude that HIV-infected women with self-reported normal menstrual cycles have normal levels of progesterone and estradiol during the menstrual cycle.

Authors+Show Affiliations

Brown University, Providence, Rhode Island, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11074951

Citation

Cu-Uvin, S, et al. "Hormonal Levels Among HIV-1-seropositive Women Compared With High-risk HIV-seronegative Women During the Menstrual Cycle. Women's Health Study (WHS) 001 and WHS 001a Study Team." Journal of Women's Health & Gender-based Medicine, vol. 9, no. 8, 2000, pp. 857-63.
Cu-Uvin S, Wright DJ, Anderson D, et al. Hormonal levels among HIV-1-seropositive women compared with high-risk HIV-seronegative women during the menstrual cycle. Women's Health Study (WHS) 001 and WHS 001a Study Team. J Womens Health Gend Based Med. 2000;9(8):857-63.
Cu-Uvin, S., Wright, D. J., Anderson, D., Kovacs, A., Watts, D. H., Cohn, J., ... Reichelderfer, P. S. (2000). Hormonal levels among HIV-1-seropositive women compared with high-risk HIV-seronegative women during the menstrual cycle. Women's Health Study (WHS) 001 and WHS 001a Study Team. Journal of Women's Health & Gender-based Medicine, 9(8), pp. 857-63.
Cu-Uvin S, et al. Hormonal Levels Among HIV-1-seropositive Women Compared With High-risk HIV-seronegative Women During the Menstrual Cycle. Women's Health Study (WHS) 001 and WHS 001a Study Team. J Womens Health Gend Based Med. 2000;9(8):857-63. PubMed PMID: 11074951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal levels among HIV-1-seropositive women compared with high-risk HIV-seronegative women during the menstrual cycle. Women's Health Study (WHS) 001 and WHS 001a Study Team. AU - Cu-Uvin,S, AU - Wright,D J, AU - Anderson,D, AU - Kovacs,A, AU - Watts,D H, AU - Cohn,J, AU - Landay,A, AU - Reichelderfer,P S, PY - 2000/11/14/pubmed PY - 2001/6/2/medline PY - 2000/11/14/entrez SP - 857 EP - 63 JF - Journal of women's health & gender-based medicine JO - J Womens Health Gend Based Med VL - 9 IS - 8 N2 - There is a paucity of normative data on hormonal levels among HIV-infected women. Hormonal levels may influence fertility and HIV-related immunological and virological factors. The objective of this study was to determine progesterone and estradiol levels during the menstrual cycle in HIV-seropositive women compared with high-risk seronegative women. The study enrolled 55 HIV-infected and 10 high-risk uninfected women with self-reported regular menstrual cycles (25-30-day cycles). Progesterone and estradiol levels were determined on a weekly basis for 8 weeks. The analysis included evaluations from the first complete menstrual cycle for the 54 HIV-infected and 9 uninfected women who had at least one complete cycle. The median age was 35 years for HIV-infected women and 36 years for uninfected women. The median CD4+ count for HIV-seropositive women was 210 cells/mm3. The median menstrual cycle length was 28 days (range 22-49 days) for HIV-infected women and 25 days (range 24-44 days) for uninfected women. The maximum progesterone level during the luteal phase was normal (>3.0 ng/ml) for 52 (96%) of 54 HIV-seropositive women and 7 (78%) of 9 HIV-seronegative women (p = 0.09, Fisher's exact test). The median maximum progesterone level was 12.2 ng/ml in HIV-seropositive women and 7.2 ng/ml in HIV-seronegative women (p = 0.07, Wilcoxon test). The median maximum estradiol value during the follicular phase was 148 pg/ml for HIV-seropositive women and 111 pg/ml for HIV-seronegative women (p = 0.04, Wilcoxon test). Among HIV-infected women, there were no significant differences in progesterone and estradiol levels by antiretroviral therapy, baseline plasma viral load, or median CD4+ cell count. We conclude that HIV-infected women with self-reported normal menstrual cycles have normal levels of progesterone and estradiol during the menstrual cycle. SN - 1524-6094 UR - https://www.unboundmedicine.com/medline/citation/11074951/Hormonal_levels_among_HIV_1_seropositive_women_compared_with_high_risk_HIV_seronegative_women_during_the_menstrual_cycle__Women's_Health_Study__WHS__001_and_WHS_001a_Study_Team_ L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -