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High carbohydrate diets, triglyceride-rich lipoproteins, and coronary heart disease risk.

Abstract

In this study we compared the effects of variations in dietary fat and carbohydrate (CHO) content on concentrations of triglyceride-rich lipoproteins in 8, healthy, nondiabetic volunteers. The diets contained, as a percentage of total calories, either 60% CHO, 25% fat, and 15% protein, or 40% CHO, 45% fat, and 15% protein. They were consumed in random order for 2 weeks, with a 2-week washout period in between. Measurements were obtained at the end of each dietary period of plasma triglyceride, cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, remnant lipoprotein (RLP) cholesterol, and RLP triglyceride concentrations, both after an overnight fast and throughout an 8-hour period (8 A.M. to 4 P.M.) in response to breakfast and lunch. The 60% CHO diet resulted in higher (mean +/- SEM) fasting plasma triglycerides (206 +/- 50 vs 113 +/- 19 mg/dl, p = 0.03), RLP cholesterol (15 +/- 6 vs 6 +/- 1 mg/dl, p = 0.005), RLP triglyceride (56 +/- 25 vs 16 +/- 3 mg/dl, p = 0.003), and lower HDL cholesterol (39 +/- 3 vs 44 +/- 3 mg/dl, p = 0.003) concentrations, without any change in LDL cholesterol concentration. Furthermore, the changes in plasma triglyceride, RLP cholesterol, and RLP triglyceride persisted throughout the day in response to breakfast and lunch. These results indicate that the effects of lowfat diets on lipoprotein metabolism are not limited to higher fasting plasma triglyceride and lower HDL cholesterol concentrations, but also include a persistent elevation in RLPs. Given the atherogenic potential of these changes in lipoprotein metabolism, it seems appropriate to question the wisdom of recommending that all Americans should replace dietary saturated fat with CHO.

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  • Authors+Show Affiliations

    ,

    Stanford University School of Medicine, California, USA.

    , , , , , ,

    Source

    The American journal of cardiology 85:1 2000 Jan 01 pg 45-8

    MeSH

    Apolipoproteins
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Coronary Disease
    Cross-Over Studies
    Dietary Carbohydrates
    Dietary Fats
    Energy Intake
    Fasting
    Female
    Humans
    Lipoproteins
    Male
    Middle Aged
    Nutrition Policy
    Time Factors
    Triglycerides

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11078235

    Citation

    Abbasi, F, et al. "High Carbohydrate Diets, Triglyceride-rich Lipoproteins, and Coronary Heart Disease Risk." The American Journal of Cardiology, vol. 85, no. 1, 2000, pp. 45-8.
    Abbasi F, McLaughlin T, Lamendola C, et al. High carbohydrate diets, triglyceride-rich lipoproteins, and coronary heart disease risk. Am J Cardiol. 2000;85(1):45-8.
    Abbasi, F., McLaughlin, T., Lamendola, C., Kim, H. S., Tanaka, A., Wang, T., ... Reaven, G. M. (2000). High carbohydrate diets, triglyceride-rich lipoproteins, and coronary heart disease risk. The American Journal of Cardiology, 85(1), pp. 45-8.
    Abbasi F, et al. High Carbohydrate Diets, Triglyceride-rich Lipoproteins, and Coronary Heart Disease Risk. Am J Cardiol. 2000 Jan 1;85(1):45-8. PubMed PMID: 11078235.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High carbohydrate diets, triglyceride-rich lipoproteins, and coronary heart disease risk. AU - Abbasi,F, AU - McLaughlin,T, AU - Lamendola,C, AU - Kim,H S, AU - Tanaka,A, AU - Wang,T, AU - Nakajima,K, AU - Reaven,G M, PY - 2000/11/15/pubmed PY - 2001/2/28/medline PY - 2000/11/15/entrez SP - 45 EP - 8 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 85 IS - 1 N2 - In this study we compared the effects of variations in dietary fat and carbohydrate (CHO) content on concentrations of triglyceride-rich lipoproteins in 8, healthy, nondiabetic volunteers. The diets contained, as a percentage of total calories, either 60% CHO, 25% fat, and 15% protein, or 40% CHO, 45% fat, and 15% protein. They were consumed in random order for 2 weeks, with a 2-week washout period in between. Measurements were obtained at the end of each dietary period of plasma triglyceride, cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, remnant lipoprotein (RLP) cholesterol, and RLP triglyceride concentrations, both after an overnight fast and throughout an 8-hour period (8 A.M. to 4 P.M.) in response to breakfast and lunch. The 60% CHO diet resulted in higher (mean +/- SEM) fasting plasma triglycerides (206 +/- 50 vs 113 +/- 19 mg/dl, p = 0.03), RLP cholesterol (15 +/- 6 vs 6 +/- 1 mg/dl, p = 0.005), RLP triglyceride (56 +/- 25 vs 16 +/- 3 mg/dl, p = 0.003), and lower HDL cholesterol (39 +/- 3 vs 44 +/- 3 mg/dl, p = 0.003) concentrations, without any change in LDL cholesterol concentration. Furthermore, the changes in plasma triglyceride, RLP cholesterol, and RLP triglyceride persisted throughout the day in response to breakfast and lunch. These results indicate that the effects of lowfat diets on lipoprotein metabolism are not limited to higher fasting plasma triglyceride and lower HDL cholesterol concentrations, but also include a persistent elevation in RLPs. Given the atherogenic potential of these changes in lipoprotein metabolism, it seems appropriate to question the wisdom of recommending that all Americans should replace dietary saturated fat with CHO. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/11078235/High_carbohydrate_diets_triglyceride_rich_lipoproteins_and_coronary_heart_disease_risk_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(99)00604-9 DB - PRIME DP - Unbound Medicine ER -