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Plasma endothelin and LH-RH, LH, FSH, prolactin, progesterone, 17alpha-hydroxyprogesterone, estrone, 17beta-estradiol, delta4-androstenedione, testosterone, active renin, angiotensin-II and ANP levels in blood and LH, estrone and 17beta-estradiol and pregnanediol levels in urine of normal cycling women.

Abstract

In order to investigate the endothelin (ET) levels and their relationship to various hormones during the menstrual cycle, we measured endothelin-1, -2 and -3 (ET-1, -2 and -3), big ET-1 and big ET-3 levels in 27 normally cycling women (mean age 27 years). Simultaneous determination of luteinizing hormone-releasing hormone (LH-RH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, progesterone, 17alpha-hydroxyprogesterone (17-OHP), estrone, 17beta-estradiol, delta4-androstenedione, testosterone, active renin, angiotensin-II (A-II) and atrial natriuretic peptide (ANP) in blood, and LH, estrone and 17beta-estradiol and pregnanediol levels in urine was made in the same 27 women. The levels of ET-2 in plasma were found to be 20% of those of ET-1. In addition, ET-1 levels were measured in the endometrium of the normal uterus. Plasma ET-1 and ET-3 levels fluctuated during the menstrual cycle, with a peak at the luteal phase, but showed only a negative relationship (p < 0.01) to each other at the menstrual phase, whereas big ET-1 and big ET-3 levels showed no significant changes. Plasma ET-1 and ET-3 levels showed no significant relationship to the big ETs. As for the relationship to other hormones, plasma ET-3 had a negative relationship (p < 0.01) to prolactin and a positive correlation (p < 0.01) with ANP during the entire menstrual cycle. Plasma ET-1 and ET-3 showed a partial positive or negative correlation to LH, FSH, prolactin and ANP levels, depending upon the cycle phase, whereas plasma ETs and big ETs were unrelated to other hormones in the blood, and LH, estrone, 17beta-estradiol and pregnanediol in the urine throughout the menstrual cycle. At each menstrual stage, plasma ET-3 levels were more significantly related to LH, FSH, prolactin and ANP than ET-1, indicating a closer relationship between ET-3 and these circulating hormones during the menstrual cycle. The ET-1 level showed no significant change in the endometrium during the menstrual cycle.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, Tennodai, Ibaraki, Japan. usukisa@igaku.md.tsukuba.ac.jp

    ,

    Source

    Journal of cardiovascular pharmacology 36:5 Suppl 1 2000 Nov pg S421-7

    MeSH

    Adult
    Androstenedione
    Angiotensin II
    Atrial Natriuretic Factor
    Endothelins
    Estradiol
    Estrone
    Female
    Follicle Stimulating Hormone
    Gonadal Steroid Hormones
    Gonadotropin-Releasing Hormone
    Gonadotropins
    Humans
    Luteinizing Hormone
    Menstrual Cycle
    Pregnanediol
    Progesterone
    Prolactin
    Renin
    Testosterone

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11078439

    Citation

    Usuki, S, et al. "Plasma Endothelin and LH-RH, LH, FSH, Prolactin, Progesterone, 17alpha-hydroxyprogesterone, Estrone, 17beta-estradiol, Delta4-androstenedione, Testosterone, Active Renin, angiotensin-II and ANP Levels in Blood and LH, Estrone and 17beta-estradiol and Pregnanediol Levels in Urine of Normal Cycling Women." Journal of Cardiovascular Pharmacology, vol. 36, no. 5 Suppl 1, 2000, pp. S421-7.
    Usuki S, Kondoh K, Kubo T. Plasma endothelin and LH-RH, LH, FSH, prolactin, progesterone, 17alpha-hydroxyprogesterone, estrone, 17beta-estradiol, delta4-androstenedione, testosterone, active renin, angiotensin-II and ANP levels in blood and LH, estrone and 17beta-estradiol and pregnanediol levels in urine of normal cycling women. J Cardiovasc Pharmacol. 2000;36(5 Suppl 1):S421-7.
    Usuki, S., Kondoh, K., & Kubo, T. (2000). Plasma endothelin and LH-RH, LH, FSH, prolactin, progesterone, 17alpha-hydroxyprogesterone, estrone, 17beta-estradiol, delta4-androstenedione, testosterone, active renin, angiotensin-II and ANP levels in blood and LH, estrone and 17beta-estradiol and pregnanediol levels in urine of normal cycling women. Journal of Cardiovascular Pharmacology, 36(5 Suppl 1), pp. S421-7.
    Usuki S, Kondoh K, Kubo T. Plasma Endothelin and LH-RH, LH, FSH, Prolactin, Progesterone, 17alpha-hydroxyprogesterone, Estrone, 17beta-estradiol, Delta4-androstenedione, Testosterone, Active Renin, angiotensin-II and ANP Levels in Blood and LH, Estrone and 17beta-estradiol and Pregnanediol Levels in Urine of Normal Cycling Women. J Cardiovasc Pharmacol. 2000;36(5 Suppl 1):S421-7. PubMed PMID: 11078439.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plasma endothelin and LH-RH, LH, FSH, prolactin, progesterone, 17alpha-hydroxyprogesterone, estrone, 17beta-estradiol, delta4-androstenedione, testosterone, active renin, angiotensin-II and ANP levels in blood and LH, estrone and 17beta-estradiol and pregnanediol levels in urine of normal cycling women. AU - Usuki,S, AU - Kondoh,K, AU - Kubo,T, PY - 2000/11/15/pubmed PY - 2001/3/3/medline PY - 2000/11/15/entrez SP - S421 EP - 7 JF - Journal of cardiovascular pharmacology JO - J. Cardiovasc. Pharmacol. VL - 36 IS - 5 Suppl 1 N2 - In order to investigate the endothelin (ET) levels and their relationship to various hormones during the menstrual cycle, we measured endothelin-1, -2 and -3 (ET-1, -2 and -3), big ET-1 and big ET-3 levels in 27 normally cycling women (mean age 27 years). Simultaneous determination of luteinizing hormone-releasing hormone (LH-RH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, progesterone, 17alpha-hydroxyprogesterone (17-OHP), estrone, 17beta-estradiol, delta4-androstenedione, testosterone, active renin, angiotensin-II (A-II) and atrial natriuretic peptide (ANP) in blood, and LH, estrone and 17beta-estradiol and pregnanediol levels in urine was made in the same 27 women. The levels of ET-2 in plasma were found to be 20% of those of ET-1. In addition, ET-1 levels were measured in the endometrium of the normal uterus. Plasma ET-1 and ET-3 levels fluctuated during the menstrual cycle, with a peak at the luteal phase, but showed only a negative relationship (p < 0.01) to each other at the menstrual phase, whereas big ET-1 and big ET-3 levels showed no significant changes. Plasma ET-1 and ET-3 levels showed no significant relationship to the big ETs. As for the relationship to other hormones, plasma ET-3 had a negative relationship (p < 0.01) to prolactin and a positive correlation (p < 0.01) with ANP during the entire menstrual cycle. Plasma ET-1 and ET-3 showed a partial positive or negative correlation to LH, FSH, prolactin and ANP levels, depending upon the cycle phase, whereas plasma ETs and big ETs were unrelated to other hormones in the blood, and LH, estrone, 17beta-estradiol and pregnanediol in the urine throughout the menstrual cycle. At each menstrual stage, plasma ET-3 levels were more significantly related to LH, FSH, prolactin and ANP than ET-1, indicating a closer relationship between ET-3 and these circulating hormones during the menstrual cycle. The ET-1 level showed no significant change in the endometrium during the menstrual cycle. SN - 0160-2446 UR - https://www.unboundmedicine.com/medline/citation/11078439/Plasma_endothelin_and_LH_RH_LH_FSH_prolactin_progesterone_17alpha_hydroxyprogesterone_estrone_17beta_estradiol_delta4_androstenedione_testosterone_active_renin_angiotensin_II_and_ANP_levels_in_blood_and_LH_estrone_and_17beta_estradiol_and_pregnanediol_levels_in_urine_of_normal_cycling_women_ L2 - http://Insights.ovid.com/pubmed?pmid=11078439 DB - PRIME DP - Unbound Medicine ER -