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Hereditary non-polyposis colorectal cancer: an updated review.
Eur J Surg Oncol. 2000 Nov; 26(7):635-45.EJ

Abstract

INTRODUCTION

Colorectal cancer is the commonest cause of death due to malignancy in non-smokers in the western countries. The two main hereditary types of colorectal cancer are familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), constituting approximately 10% of all cases of colorectal cancer. The main aim of this review is to reappraise the current advances in the genetics and diagnosis of HNPCC.

METHODS

A Medline search was carried out to identify papers published from 1970 to 1999 on HNPCC. Embase and Cochrane databases were also searched. Reference lists of retrieved articles were carefully searched for additional articles.

RESULTS AND CONCLUSIONS

Recent technological advances in the genetics of HNPCC have refined the criteria for diagnosis and management of HNPCC, however current policies regarding the testing of pedigrees are not clearly established. We believe that with the rapid development in this area definitive clinical guidelines will need to be available in future for the management of HNPCC.

Authors+Show Affiliations

Department of Surgery, North Manchester General Hospital, Manchester, UK. suhail@anwar99.freeserve.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11078609

Citation

Anwar, S, et al. "Hereditary Non-polyposis Colorectal Cancer: an Updated Review." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 26, no. 7, 2000, pp. 635-45.
Anwar S, Hall C, White J, et al. Hereditary non-polyposis colorectal cancer: an updated review. Eur J Surg Oncol. 2000;26(7):635-45.
Anwar, S., Hall, C., White, J., Deakin, M., Farrell, W., & Elder, J. B. (2000). Hereditary non-polyposis colorectal cancer: an updated review. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 26(7), 635-45.
Anwar S, et al. Hereditary Non-polyposis Colorectal Cancer: an Updated Review. Eur J Surg Oncol. 2000;26(7):635-45. PubMed PMID: 11078609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary non-polyposis colorectal cancer: an updated review. AU - Anwar,S, AU - Hall,C, AU - White,J, AU - Deakin,M, AU - Farrell,W, AU - Elder,J B, PY - 2000/11/18/pubmed PY - 2001/2/28/medline PY - 2000/11/18/entrez SP - 635 EP - 45 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 26 IS - 7 N2 - INTRODUCTION: Colorectal cancer is the commonest cause of death due to malignancy in non-smokers in the western countries. The two main hereditary types of colorectal cancer are familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC), constituting approximately 10% of all cases of colorectal cancer. The main aim of this review is to reappraise the current advances in the genetics and diagnosis of HNPCC. METHODS: A Medline search was carried out to identify papers published from 1970 to 1999 on HNPCC. Embase and Cochrane databases were also searched. Reference lists of retrieved articles were carefully searched for additional articles. RESULTS AND CONCLUSIONS: Recent technological advances in the genetics of HNPCC have refined the criteria for diagnosis and management of HNPCC, however current policies regarding the testing of pedigrees are not clearly established. We believe that with the rapid development in this area definitive clinical guidelines will need to be available in future for the management of HNPCC. SN - 0748-7983 UR - https://www.unboundmedicine.com/medline/citation/11078609/Hereditary_non_polyposis_colorectal_cancer:_an_updated_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0748-7983(00)90974-0 DB - PRIME DP - Unbound Medicine ER -