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Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage.
Am J Ophthalmol. 2000 Nov; 130(5):597-605.AJ

Abstract

PURPOSE

To evaluate the relationship between ocular perfusion pressure and color Doppler measurements in patients with glaucoma.

MATERIALS AND METHODS

Twenty patients with primary open-angle glaucoma with visual field deterioration in spite of an intraocular pressure lowered below 21 mm Hg, 20 age-matched patients with glaucoma with stable visual fields, and 20 age-matched healthy controls were recruited. After a 20-minute rest in a supine position, intraocular pressure and color Doppler measurements parameters of the ophthalmic artery and the central retinal artery were obtained. Correlations between mean ocular perfusion pressure and color Doppler measurements parameters were determined.

RESULTS

Patients with glaucoma showed a higher intraocular pressure (P <.0008) and a lower mean ocular perfusion pressure (P <.0045) compared with healthy subjects. Patients with deteriorating glaucoma showed a lower mean blood pressure (P =.033) and a lower end diastolic velocity in the central retinal artery (P =.0093) compared with normals. Mean ocular perfusion pressure correlated positively with end diastolic velocity in the ophthalmic artery (R = 0.66, P =.002) and central retinal artery (R = 0.74, P <.0001) and negatively with resistivity index in the ophthalmic artery (R = -0.70, P =.001) and central retinal artery (R = -0.62, P =.003) in patients with deteriorating glaucoma. Such correlations did not occur in patients with glaucoma with stable visual fields or in normal subjects. The correlations were statistically significantly different between the study groups (parallelism of regression lines in an analysis of covariance model) for end diastolic velocity (P =.001) and resistivity index (P =.0001) in the ophthalmic artery, as well as for end diastolic velocity (P =.0009) and resistivity index (P =. 001) in the central retinal artery.

CONCLUSIONS

The present findings suggest that alterations in ocular blood flow regulation may contribute to the progression in glaucomatous damage.

Authors+Show Affiliations

University Eye Clinic, Basel, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11078838

Citation

Gherghel, D, et al. "Relationship Between Ocular Perfusion Pressure and Retrobulbar Blood Flow in Patients With Glaucoma With Progressive Damage." American Journal of Ophthalmology, vol. 130, no. 5, 2000, pp. 597-605.
Gherghel D, Orgül S, Gugleta K, et al. Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage. Am J Ophthalmol. 2000;130(5):597-605.
Gherghel, D., Orgül, S., Gugleta, K., Gekkieva, M., & Flammer, J. (2000). Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage. American Journal of Ophthalmology, 130(5), 597-605.
Gherghel D, et al. Relationship Between Ocular Perfusion Pressure and Retrobulbar Blood Flow in Patients With Glaucoma With Progressive Damage. Am J Ophthalmol. 2000;130(5):597-605. PubMed PMID: 11078838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage. AU - Gherghel,D, AU - Orgül,S, AU - Gugleta,K, AU - Gekkieva,M, AU - Flammer,J, PY - 2000/11/18/pubmed PY - 2001/2/28/medline PY - 2000/11/18/entrez SP - 597 EP - 605 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 130 IS - 5 N2 - PURPOSE: To evaluate the relationship between ocular perfusion pressure and color Doppler measurements in patients with glaucoma. MATERIALS AND METHODS: Twenty patients with primary open-angle glaucoma with visual field deterioration in spite of an intraocular pressure lowered below 21 mm Hg, 20 age-matched patients with glaucoma with stable visual fields, and 20 age-matched healthy controls were recruited. After a 20-minute rest in a supine position, intraocular pressure and color Doppler measurements parameters of the ophthalmic artery and the central retinal artery were obtained. Correlations between mean ocular perfusion pressure and color Doppler measurements parameters were determined. RESULTS: Patients with glaucoma showed a higher intraocular pressure (P <.0008) and a lower mean ocular perfusion pressure (P <.0045) compared with healthy subjects. Patients with deteriorating glaucoma showed a lower mean blood pressure (P =.033) and a lower end diastolic velocity in the central retinal artery (P =.0093) compared with normals. Mean ocular perfusion pressure correlated positively with end diastolic velocity in the ophthalmic artery (R = 0.66, P =.002) and central retinal artery (R = 0.74, P <.0001) and negatively with resistivity index in the ophthalmic artery (R = -0.70, P =.001) and central retinal artery (R = -0.62, P =.003) in patients with deteriorating glaucoma. Such correlations did not occur in patients with glaucoma with stable visual fields or in normal subjects. The correlations were statistically significantly different between the study groups (parallelism of regression lines in an analysis of covariance model) for end diastolic velocity (P =.001) and resistivity index (P =.0001) in the ophthalmic artery, as well as for end diastolic velocity (P =.0009) and resistivity index (P =. 001) in the central retinal artery. CONCLUSIONS: The present findings suggest that alterations in ocular blood flow regulation may contribute to the progression in glaucomatous damage. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/11078838/Relationship_between_ocular_perfusion_pressure_and_retrobulbar_blood_flow_in_patients_with_glaucoma_with_progressive_damage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002939400007662 DB - PRIME DP - Unbound Medicine ER -