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Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese.

Abstract

There is now overwhelming evidence that the varepsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (I/D) DNA polymorphism at the intron 16 of ACE gene has been found associated with late-onset AD, but the results are not consistent. We have examined ACE gene in a cohort of Han Chinese AD cases and controls. We have found the ACE-I allele was enriched in our cases compared to controls (odds ratio (OR)=2.09, P=0.0043). The phenomenon was restricted to cases presenting with AD after the age of 70 years (P<0.0005), and was independent of APOE genotype. We conclude that ACE genotype is a risk factor for late onset AD.

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  • Authors+Show Affiliations

    ,

    Bio-X Life Science Research Center, Shanghai Jiao Tong University, 200030, People's Republic of, Shanghai, China.

    , , , , , ,

    Source

    Neuroscience letters 295:1-2 2000 Dec 01 pg 41-4

    MeSH

    Age Factors
    Aged
    Aged, 80 and over
    Alleles
    Alzheimer Disease
    Case-Control Studies
    China
    Female
    Genotype
    Humans
    Male
    Middle Aged
    Odds Ratio
    Peptidyl-Dipeptidase A
    Polymorphism, Genetic

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11078932

    Citation

    Yang, J D., et al. "Association Between Angiotensin-converting Enzyme Gene and Late Onset Alzheimer's Disease in Han Chinese." Neuroscience Letters, vol. 295, no. 1-2, 2000, pp. 41-4.
    Yang JD, Feng G, Zhang J, et al. Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese. Neurosci Lett. 2000;295(1-2):41-4.
    Yang, J. D., Feng, G., Zhang, J., Lin, Z. X., Shen, T., Breen, G., ... He, L. (2000). Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese. Neuroscience Letters, 295(1-2), pp. 41-4.
    Yang JD, et al. Association Between Angiotensin-converting Enzyme Gene and Late Onset Alzheimer's Disease in Han Chinese. Neurosci Lett. 2000 Dec 1;295(1-2):41-4. PubMed PMID: 11078932.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese. AU - Yang,J D, AU - Feng,G, AU - Zhang,J, AU - Lin,Z X, AU - Shen,T, AU - Breen,G, AU - St Clair,D, AU - He,L, PY - 2000/11/18/pubmed PY - 2001/2/28/medline PY - 2000/11/18/entrez SP - 41 EP - 4 JF - Neuroscience letters JO - Neurosci. Lett. VL - 295 IS - 1-2 N2 - There is now overwhelming evidence that the varepsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (I/D) DNA polymorphism at the intron 16 of ACE gene has been found associated with late-onset AD, but the results are not consistent. We have examined ACE gene in a cohort of Han Chinese AD cases and controls. We have found the ACE-I allele was enriched in our cases compared to controls (odds ratio (OR)=2.09, P=0.0043). The phenomenon was restricted to cases presenting with AD after the age of 70 years (P<0.0005), and was independent of APOE genotype. We conclude that ACE genotype is a risk factor for late onset AD. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/11078932/Association_between_angiotensin_converting_enzyme_gene_and_late_onset_Alzheimer's_disease_in_Han_chinese_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(00)01591-3 DB - PRIME DP - Unbound Medicine ER -