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Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese.
Neurosci Lett 2000; 295(1-2):41-4NL

Abstract

There is now overwhelming evidence that the varepsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (I/D) DNA polymorphism at the intron 16 of ACE gene has been found associated with late-onset AD, but the results are not consistent. We have examined ACE gene in a cohort of Han Chinese AD cases and controls. We have found the ACE-I allele was enriched in our cases compared to controls (odds ratio (OR)=2.09, P=0.0043). The phenomenon was restricted to cases presenting with AD after the age of 70 years (P<0.0005), and was independent of APOE genotype. We conclude that ACE genotype is a risk factor for late onset AD.

Authors+Show Affiliations

Bio-X Life Science Research Center, Shanghai Jiao Tong University, 200030, People's Republic of, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11078932

Citation

Yang, J D., et al. "Association Between Angiotensin-converting Enzyme Gene and Late Onset Alzheimer's Disease in Han Chinese." Neuroscience Letters, vol. 295, no. 1-2, 2000, pp. 41-4.
Yang JD, Feng G, Zhang J, et al. Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese. Neurosci Lett. 2000;295(1-2):41-4.
Yang, J. D., Feng, G., Zhang, J., Lin, Z. X., Shen, T., Breen, G., ... He, L. (2000). Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese. Neuroscience Letters, 295(1-2), pp. 41-4.
Yang JD, et al. Association Between Angiotensin-converting Enzyme Gene and Late Onset Alzheimer's Disease in Han Chinese. Neurosci Lett. 2000 Dec 1;295(1-2):41-4. PubMed PMID: 11078932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese. AU - Yang,J D, AU - Feng,G, AU - Zhang,J, AU - Lin,Z X, AU - Shen,T, AU - Breen,G, AU - St Clair,D, AU - He,L, PY - 2000/11/18/pubmed PY - 2001/2/28/medline PY - 2000/11/18/entrez SP - 41 EP - 4 JF - Neuroscience letters JO - Neurosci. Lett. VL - 295 IS - 1-2 N2 - There is now overwhelming evidence that the varepsilon4 allele of apolipoprotein (APOE) gene is a major risk factor for late-onset Alzheimer's disease (AD). However, the APOE locus only accounts for a proportion of the overall genetic risk for AD. The angiotensin-converting enzyme (ACE) is widely expressed in the brain and may have a role in AD. Recently an insertion/deletion (I/D) DNA polymorphism at the intron 16 of ACE gene has been found associated with late-onset AD, but the results are not consistent. We have examined ACE gene in a cohort of Han Chinese AD cases and controls. We have found the ACE-I allele was enriched in our cases compared to controls (odds ratio (OR)=2.09, P=0.0043). The phenomenon was restricted to cases presenting with AD after the age of 70 years (P<0.0005), and was independent of APOE genotype. We conclude that ACE genotype is a risk factor for late onset AD. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/11078932/Association_between_angiotensin_converting_enzyme_gene_and_late_onset_Alzheimer's_disease_in_Han_chinese_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(00)01591-3 DB - PRIME DP - Unbound Medicine ER -