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Lipid and lipoprotein patterns in type 2 non-obese diabetic patients. Do Lp(a) levels decrease with improved glycemic control in these patients?
Nutr Metab Cardiovasc Dis. 2000 Aug; 10(4):204-8.NM

Abstract

BACKGROUND AND AIM

In this study, we investigated the levels of apolipopotein-AI (apo-AI), apolipoprotein (apo-B), triglyceride (TG), high-density-lipoprotein-cholesterol (HDL-C), low-density-lipoprotein-cholesterol (LDL-C), total cholesterol, lipoprotein(a) in a group of non-obese, type 2 diabetes mellitus patients with different types of treatment and a control group of non-obese, non-diabetic subjects.

METHODS AND RESULTS

Patients were divided into three groups according to their treatment types: insulin, sulphonylurea and untreated groups. All groups were similar in sex, weights, known duration of diabetes and habits. Each group consisted of 30 subjects. There were no differences in apo-AI, apo-B and TG levels (p > 0.05), whereas HDL-C levels in the untreated group were significantly lower than those of the other groups (p < 0.05). Lp(a) levels in the untreated group were higher than in the other (p < 0.05).

CONCLUSIONS

Gaining metabolic control in diabetes mellitus is crucial in pulling back lipid, lipoprotein and apolipoprotein levels to a desired level and in attenuating CAD (coronary artery disease) risk factors, and also in preventing CAD. Lp(a) levels in particular are decreased by insulin or sulfonylurea in non-obese patients with type 2 diabetes mellitus.

Authors+Show Affiliations

Department of Internal Medicine, Cumhuriyet University, Sivas, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11079258

Citation

Alagözlü, H, et al. "Lipid and Lipoprotein Patterns in Type 2 Non-obese Diabetic Patients. Do Lp(a) Levels Decrease With Improved Glycemic Control in These Patients?" Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 10, no. 4, 2000, pp. 204-8.
Alagözlü H, Gültekin F, Candan F. Lipid and lipoprotein patterns in type 2 non-obese diabetic patients. Do Lp(a) levels decrease with improved glycemic control in these patients? Nutr Metab Cardiovasc Dis. 2000;10(4):204-8.
Alagözlü, H., Gültekin, F., & Candan, F. (2000). Lipid and lipoprotein patterns in type 2 non-obese diabetic patients. Do Lp(a) levels decrease with improved glycemic control in these patients? Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 10(4), 204-8.
Alagözlü H, Gültekin F, Candan F. Lipid and Lipoprotein Patterns in Type 2 Non-obese Diabetic Patients. Do Lp(a) Levels Decrease With Improved Glycemic Control in These Patients. Nutr Metab Cardiovasc Dis. 2000;10(4):204-8. PubMed PMID: 11079258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid and lipoprotein patterns in type 2 non-obese diabetic patients. Do Lp(a) levels decrease with improved glycemic control in these patients? AU - Alagözlü,H, AU - Gültekin,F, AU - Candan,F, PY - 2000/11/18/pubmed PY - 2001/3/3/medline PY - 2000/11/18/entrez SP - 204 EP - 8 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 10 IS - 4 N2 - BACKGROUND AND AIM: In this study, we investigated the levels of apolipopotein-AI (apo-AI), apolipoprotein (apo-B), triglyceride (TG), high-density-lipoprotein-cholesterol (HDL-C), low-density-lipoprotein-cholesterol (LDL-C), total cholesterol, lipoprotein(a) in a group of non-obese, type 2 diabetes mellitus patients with different types of treatment and a control group of non-obese, non-diabetic subjects. METHODS AND RESULTS: Patients were divided into three groups according to their treatment types: insulin, sulphonylurea and untreated groups. All groups were similar in sex, weights, known duration of diabetes and habits. Each group consisted of 30 subjects. There were no differences in apo-AI, apo-B and TG levels (p > 0.05), whereas HDL-C levels in the untreated group were significantly lower than those of the other groups (p < 0.05). Lp(a) levels in the untreated group were higher than in the other (p < 0.05). CONCLUSIONS: Gaining metabolic control in diabetes mellitus is crucial in pulling back lipid, lipoprotein and apolipoprotein levels to a desired level and in attenuating CAD (coronary artery disease) risk factors, and also in preventing CAD. Lp(a) levels in particular are decreased by insulin or sulfonylurea in non-obese patients with type 2 diabetes mellitus. SN - 0939-4753 UR - https://www.unboundmedicine.com/medline/citation/11079258/Lipid_and_lipoprotein_patterns_in_type_2_non_obese_diabetic_patients__Do_Lp_a__levels_decrease_with_improved_glycemic_control_in_these_patients DB - PRIME DP - Unbound Medicine ER -