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Quantitative study of ductal breast cancer progression: signatures of nuclei in proliferating breast lesions and in situ cancer.
Adv Clin Path. 2000 Apr; 4(2):87-97.AC

Abstract

AIMS

The objective of this study is to derive highly specific nuclear signatures (NS's) for the characterization of nuclei of ductal breast epithelium in proliferative lesions and in situ cancers in order to evaluate if nuclear structural changes are able to describe the main events of ductal cancer progression and if the method can be used for objective grading.

METHODS

A total of 82 different features descriptive of the nuclear chromatin patterns were computed in nuclei from normal glandular breast tissue, florid hyperplasia, and ductal carcinoma in situ (DCIS) and of DCIS with microinfiltration. The feature values were arranged to form a profile or signature. Measures of difference to a standard profile derived from normal glandular breast tissue were defined. One may then compute a standardized distance measure for a nucleus from "normal". Lesions can be characterized in the same manner, on the basis of the mean profile for all of their nuclei, and on the basis of the distribution of distances of their constituent nuclei from normal.

RESULTS

The selected histopathologic patterns on which the diagnostic categories for DCIS are based were found to have corresponding distinctive patterns in the chromatin of the lesion's nuclei. A monotonic trend of ductal neoplastic progression was found. In addition, lesions histologically assessed as belonging to the same diagnostic category were found to offer substantially different distribution patterns.

CONCLUSIONS

The full utilization of nuclear texture features allows the derivation of highly specific signatures for nuclei so that a reproducible grading can be performed for prognostic purposes.

Authors+Show Affiliations

Istituto di Anatomia Patologica, Università di Udine, Italy. laura.mariuzzi@drmm.uniud.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11080789

Citation

Mariuzzi, L, et al. "Quantitative Study of Ductal Breast Cancer Progression: Signatures of Nuclei in Proliferating Breast Lesions and in Situ Cancer." Advances in Clinical Pathology : the Official Journal of Adriatic Society of Pathology, vol. 4, no. 2, 2000, pp. 87-97.
Mariuzzi L, Mombello A, Rucco V, et al. Quantitative study of ductal breast cancer progression: signatures of nuclei in proliferating breast lesions and in situ cancer. Adv Clin Path. 2000;4(2):87-97.
Mariuzzi, L., Mombello, A., Rucco, V., Morelli, L., Zamò, A., Thompson, D., Vaught, L., Bartels, H. G., Mariuzzi, G., & Bartels, P. H. (2000). Quantitative study of ductal breast cancer progression: signatures of nuclei in proliferating breast lesions and in situ cancer. Advances in Clinical Pathology : the Official Journal of Adriatic Society of Pathology, 4(2), 87-97.
Mariuzzi L, et al. Quantitative Study of Ductal Breast Cancer Progression: Signatures of Nuclei in Proliferating Breast Lesions and in Situ Cancer. Adv Clin Path. 2000;4(2):87-97. PubMed PMID: 11080789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative study of ductal breast cancer progression: signatures of nuclei in proliferating breast lesions and in situ cancer. AU - Mariuzzi,L, AU - Mombello,A, AU - Rucco,V, AU - Morelli,L, AU - Zamò,A, AU - Thompson,D, AU - Vaught,L, AU - Bartels,H G, AU - Mariuzzi,G, AU - Bartels,P H, PY - 2000/11/18/pubmed PY - 2001/2/28/medline PY - 2000/11/18/entrez SP - 87 EP - 97 JF - Advances in clinical pathology : the official journal of Adriatic Society of Pathology JO - Adv Clin Path VL - 4 IS - 2 N2 - AIMS: The objective of this study is to derive highly specific nuclear signatures (NS's) for the characterization of nuclei of ductal breast epithelium in proliferative lesions and in situ cancers in order to evaluate if nuclear structural changes are able to describe the main events of ductal cancer progression and if the method can be used for objective grading. METHODS: A total of 82 different features descriptive of the nuclear chromatin patterns were computed in nuclei from normal glandular breast tissue, florid hyperplasia, and ductal carcinoma in situ (DCIS) and of DCIS with microinfiltration. The feature values were arranged to form a profile or signature. Measures of difference to a standard profile derived from normal glandular breast tissue were defined. One may then compute a standardized distance measure for a nucleus from "normal". Lesions can be characterized in the same manner, on the basis of the mean profile for all of their nuclei, and on the basis of the distribution of distances of their constituent nuclei from normal. RESULTS: The selected histopathologic patterns on which the diagnostic categories for DCIS are based were found to have corresponding distinctive patterns in the chromatin of the lesion's nuclei. A monotonic trend of ductal neoplastic progression was found. In addition, lesions histologically assessed as belonging to the same diagnostic category were found to offer substantially different distribution patterns. CONCLUSIONS: The full utilization of nuclear texture features allows the derivation of highly specific signatures for nuclei so that a reproducible grading can be performed for prognostic purposes. SN - 1125-5552 UR - https://www.unboundmedicine.com/medline/citation/11080789/Quantitative_study_of_ductal_breast_cancer_progression:_signatures_of_nuclei_in_proliferating_breast_lesions_and_in_situ_cancer_ L2 - https://www.diseaseinfosearch.org/result/960 DB - PRIME DP - Unbound Medicine ER -