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PYCNOGENOL in chronic venous insufficiency.
Phytomedicine. 2000 Oct; 7(5):383-8.P

Abstract

The aim of out study was to investigate the efficacy of Pycnogenol - a French maritime pine bark extract - in the treatment of chronic venous insufficiency (CVI). The study consisted of a double-blind phase - in which 20 patients were recruited and randomly treated with placebo or Pycnogenol (100 mg 2 3/day for 2 months) - and an open phase - in which other 20 patients were treated with Pycnogenol at the same dose schedule. In total, 40 patients were enrolled; 30 of them were treated with Pycnogenol and 10 with placebo. Pycnogenol significantly improved the legs' heaviness and subcutaneous edema; the venous pressure was also significantly reduced by the Pycnogenol treatment, thus adding further clinical evidence to its therapeutic efficacy in patients with CVI. Pycnogenol was effective, probably by either stabilizing the collagenous subendothelial basal membrane or scavenging the free radicals, or by a combination of these activities. Clinically, capillary leakage, perivascular inflammation and subcutaneous edema were all reduced. The safety of use of Pycnogenol is demonstrated by the lack of side effects or changes in blood biochemistry and hematologic parameters. Pycnogenol can be therefore recommended both for prevention and treatment of CVI and related veno-capillary disturbances.

Authors+Show Affiliations

Cattedra e Scuola di Specializzazione in Chirurgia Vascolare, Dipartimento di Scienze Chirurgiche, Università degli Studi di L'Aquila, Italy. chirvasc@cc.univaq.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11081989

Citation

Petrassi, C, et al. "PYCNOGENOL in Chronic Venous Insufficiency." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 7, no. 5, 2000, pp. 383-8.
Petrassi C, Mastromarino A, Spartera C. PYCNOGENOL in chronic venous insufficiency. Phytomedicine. 2000;7(5):383-8.
Petrassi, C., Mastromarino, A., & Spartera, C. (2000). PYCNOGENOL in chronic venous insufficiency. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 7(5), 383-8.
Petrassi C, Mastromarino A, Spartera C. PYCNOGENOL in Chronic Venous Insufficiency. Phytomedicine. 2000;7(5):383-8. PubMed PMID: 11081989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PYCNOGENOL in chronic venous insufficiency. AU - Petrassi,C, AU - Mastromarino,A, AU - Spartera,C, PY - 2000/11/18/pubmed PY - 2001/4/21/medline PY - 2000/11/18/entrez SP - 383 EP - 8 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 7 IS - 5 N2 - The aim of out study was to investigate the efficacy of Pycnogenol - a French maritime pine bark extract - in the treatment of chronic venous insufficiency (CVI). The study consisted of a double-blind phase - in which 20 patients were recruited and randomly treated with placebo or Pycnogenol (100 mg 2 3/day for 2 months) - and an open phase - in which other 20 patients were treated with Pycnogenol at the same dose schedule. In total, 40 patients were enrolled; 30 of them were treated with Pycnogenol and 10 with placebo. Pycnogenol significantly improved the legs' heaviness and subcutaneous edema; the venous pressure was also significantly reduced by the Pycnogenol treatment, thus adding further clinical evidence to its therapeutic efficacy in patients with CVI. Pycnogenol was effective, probably by either stabilizing the collagenous subendothelial basal membrane or scavenging the free radicals, or by a combination of these activities. Clinically, capillary leakage, perivascular inflammation and subcutaneous edema were all reduced. The safety of use of Pycnogenol is demonstrated by the lack of side effects or changes in blood biochemistry and hematologic parameters. Pycnogenol can be therefore recommended both for prevention and treatment of CVI and related veno-capillary disturbances. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/11081989/PYCNOGENOL_in_chronic_venous_insufficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(00)80059-8 DB - PRIME DP - Unbound Medicine ER -