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Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats.
J Biochem Mol Toxicol. 2000; 14(6):329-34.JB

Abstract

Using diabetes mellitus as a model of oxidative damage, this study investigated whether subacute treatment (10 mg/kg/day, intraperitoneally for 14 days) with the compound piperine would protect against diabetes-induced oxidative stress in 30-day streptozotocin-induced diabetic Sprague-Dawley rats. Liver, kidney, brain, and heart were assayed for degree of lipid peroxidation, reduced and oxidized glutathione (GSH and GSSG, respectively) content, and activities of the free-radical detoxifying enzymes catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase. Piperine treatment of normal rats enhanced hepatic GSSG concentration by 100% and decreased renal GSH concentration by 35% and renal glutathione reductase activity by 25% when compared to normal controls. All tissues from diabetic animals exhibited disturbances in antioxidant defense when compared with normal controls. Treatment with piperine reversed the diabetic effects on GSSG concentration in brain, on renal glutathione peroxidase and superoxide dismutase activities, and on cardiac glutathione reductase activity and lipid peroxidation. Piperine treatment did not reverse the effects of diabetes on hepatic GSH concentrations, lipid peroxidation, or glutathione peroxidase or catalase activities; on renal superoxide dismutase activity; or on cardiac glutathione peroxidase or catalase activities. These data indicate that subacute treatment with piperine for 14 days is only partially effective as an antioxidant therapy in diabetes.

Authors+Show Affiliations

Medical Sciences Program, Indiana University School of Medicine, Bloomington 47405-7005, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11083086

Citation

Rauscher, F M., et al. "Effects of Piperine On Antioxidant Pathways in Tissues From Normal and Streptozotocin-induced Diabetic Rats." Journal of Biochemical and Molecular Toxicology, vol. 14, no. 6, 2000, pp. 329-34.
Rauscher FM, Sanders RA, Watkins JB. Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats. J Biochem Mol Toxicol. 2000;14(6):329-34.
Rauscher, F. M., Sanders, R. A., & Watkins, J. B. (2000). Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats. Journal of Biochemical and Molecular Toxicology, 14(6), 329-34.
Rauscher FM, Sanders RA, Watkins JB. Effects of Piperine On Antioxidant Pathways in Tissues From Normal and Streptozotocin-induced Diabetic Rats. J Biochem Mol Toxicol. 2000;14(6):329-34. PubMed PMID: 11083086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats. AU - Rauscher,F M, AU - Sanders,R A, AU - Watkins,J B,3rd PY - 2000/11/18/pubmed PY - 2001/6/2/medline PY - 2000/11/18/entrez SP - 329 EP - 34 JF - Journal of biochemical and molecular toxicology JO - J Biochem Mol Toxicol VL - 14 IS - 6 N2 - Using diabetes mellitus as a model of oxidative damage, this study investigated whether subacute treatment (10 mg/kg/day, intraperitoneally for 14 days) with the compound piperine would protect against diabetes-induced oxidative stress in 30-day streptozotocin-induced diabetic Sprague-Dawley rats. Liver, kidney, brain, and heart were assayed for degree of lipid peroxidation, reduced and oxidized glutathione (GSH and GSSG, respectively) content, and activities of the free-radical detoxifying enzymes catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase. Piperine treatment of normal rats enhanced hepatic GSSG concentration by 100% and decreased renal GSH concentration by 35% and renal glutathione reductase activity by 25% when compared to normal controls. All tissues from diabetic animals exhibited disturbances in antioxidant defense when compared with normal controls. Treatment with piperine reversed the diabetic effects on GSSG concentration in brain, on renal glutathione peroxidase and superoxide dismutase activities, and on cardiac glutathione reductase activity and lipid peroxidation. Piperine treatment did not reverse the effects of diabetes on hepatic GSH concentrations, lipid peroxidation, or glutathione peroxidase or catalase activities; on renal superoxide dismutase activity; or on cardiac glutathione peroxidase or catalase activities. These data indicate that subacute treatment with piperine for 14 days is only partially effective as an antioxidant therapy in diabetes. SN - 1095-6670 UR - https://www.unboundmedicine.com/medline/citation/11083086/Effects_of_piperine_on_antioxidant_pathways_in_tissues_from_normal_and_streptozotocin_induced_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -