Tags

Type your tag names separated by a space and hit enter

Quinupristin-dalfopristin resistance among gram-positive bacteria in Taiwan.
Antimicrob Agents Chemother. 2000 Dec; 44(12):3374-80.AA

Abstract

To understand quinupristin-dalfopristin resistance among clinical isolates of gram-positive bacteria in Taiwan, where this agent is not yet available for clinical use, we evaluated 1,287 nonduplicate isolates recovered from January 1996 to December 1999 for in vitro susceptibility to quinupristin-dalfopristin and other newer antimicrobial agents. All methicillin-susceptible Staphylococcus aureus (MSSA) isolates were susceptible to quinupristin-dalfopristin. High rates of nonsusceptibility to quinupristin-dalfopristin (MICs, >/=2 microg/ml) were demonstrated for the following organisms: methicillin-resistant S. aureus (MRSA) (31%), coagulase-negative staphylococci (CoNS) (16%), Streptococcus pneumoniae (8%), viridans group streptococci (51%), vancomycin-susceptible enterococci (85%), vancomycin-resistant Enterococcus faecalis (100%), vancomycin-resistant Enterococcus faecium (66%), Leuconostoc spp. (100%), Lactobacillus spp. (50%), and Pediococcus spp. (87%). All isolates of MSSA, MRSA, S. pneumoniae, and viridans group streptococci were susceptible to vancomycin and teicoplanin. The rates of nonsusceptibility to vancomycin and teicoplanin were 5 and 7%, respectively, for CoNS, ranging from 12 and 18% for S. simulans to 0 and 0% for S. cohnii and S. auricularis. Moxifloxacin and trovafloxacin had good activities against these isolates except for ciprofloxacin-resistant vancomycin-resistant enterococci and methicillin-resistant staphylococci. In Taiwan, virginiamycin has been used in animal husbandry for more than 20 years, which may contribute to the high rates of quinupristin-dalfopristin resistance.

Authors+Show Affiliations

Departments of Laboratory Medicine, School of Medical Technology, National Taiwan University College of Medicine, Taiwan. lukt@ha.mc.ntu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11083643

Citation

Luh, K T., et al. "Quinupristin-dalfopristin Resistance Among Gram-positive Bacteria in Taiwan." Antimicrobial Agents and Chemotherapy, vol. 44, no. 12, 2000, pp. 3374-80.
Luh KT, Hsueh PR, Teng LJ, et al. Quinupristin-dalfopristin resistance among gram-positive bacteria in Taiwan. Antimicrob Agents Chemother. 2000;44(12):3374-80.
Luh, K. T., Hsueh, P. R., Teng, L. J., Pan, H. J., Chen, Y. C., Lu, J. J., Wu, J. J., & Ho, S. W. (2000). Quinupristin-dalfopristin resistance among gram-positive bacteria in Taiwan. Antimicrobial Agents and Chemotherapy, 44(12), 3374-80.
Luh KT, et al. Quinupristin-dalfopristin Resistance Among Gram-positive Bacteria in Taiwan. Antimicrob Agents Chemother. 2000;44(12):3374-80. PubMed PMID: 11083643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quinupristin-dalfopristin resistance among gram-positive bacteria in Taiwan. AU - Luh,K T, AU - Hsueh,P R, AU - Teng,L J, AU - Pan,H J, AU - Chen,Y C, AU - Lu,J J, AU - Wu,J J, AU - Ho,S W, PY - 2000/11/18/pubmed PY - 2001/3/3/medline PY - 2000/11/18/entrez SP - 3374 EP - 80 JF - Antimicrobial agents and chemotherapy JO - Antimicrob Agents Chemother VL - 44 IS - 12 N2 - To understand quinupristin-dalfopristin resistance among clinical isolates of gram-positive bacteria in Taiwan, where this agent is not yet available for clinical use, we evaluated 1,287 nonduplicate isolates recovered from January 1996 to December 1999 for in vitro susceptibility to quinupristin-dalfopristin and other newer antimicrobial agents. All methicillin-susceptible Staphylococcus aureus (MSSA) isolates were susceptible to quinupristin-dalfopristin. High rates of nonsusceptibility to quinupristin-dalfopristin (MICs, >/=2 microg/ml) were demonstrated for the following organisms: methicillin-resistant S. aureus (MRSA) (31%), coagulase-negative staphylococci (CoNS) (16%), Streptococcus pneumoniae (8%), viridans group streptococci (51%), vancomycin-susceptible enterococci (85%), vancomycin-resistant Enterococcus faecalis (100%), vancomycin-resistant Enterococcus faecium (66%), Leuconostoc spp. (100%), Lactobacillus spp. (50%), and Pediococcus spp. (87%). All isolates of MSSA, MRSA, S. pneumoniae, and viridans group streptococci were susceptible to vancomycin and teicoplanin. The rates of nonsusceptibility to vancomycin and teicoplanin were 5 and 7%, respectively, for CoNS, ranging from 12 and 18% for S. simulans to 0 and 0% for S. cohnii and S. auricularis. Moxifloxacin and trovafloxacin had good activities against these isolates except for ciprofloxacin-resistant vancomycin-resistant enterococci and methicillin-resistant staphylococci. In Taiwan, virginiamycin has been used in animal husbandry for more than 20 years, which may contribute to the high rates of quinupristin-dalfopristin resistance. SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/11083643/Quinupristin_dalfopristin_resistance_among_gram_positive_bacteria_in_Taiwan_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=11083643 DB - PRIME DP - Unbound Medicine ER -