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Conditioned nutritional requirements and the pathogenesis and treatment of myocardial failure.
Curr Opin Clin Nutr Metab Care 2000; 3(6):417-24CO

Abstract

The majority of symptomatic patients with congestive heart failure have been shown to be significantly malnourished. Myocardial and skeletal muscle energy reserves are also diminished. Total daily energy expenditure in these patients is less than that in control individuals, and high protein-calorie feeds do not reverse the abnormalities; thus, the wasting that occurs in patients with congestive heart failure is metabolic rather than because of negative protein-calorie balance. Several specific deficiencies have been found in the failing myocardium: a reduction in the content of L-carnitine, coenzyme Q10, creatine and thiamine, nutrient cofactors that are important for myocardial energy production; a relative deficiency of taurine, an amino acid that is integral to the modulation of intracellular calcium levels; and an increase in myocardial oxidative stress, and a reduction of both endogenous and exogenous antioxidant defences. In addition, these processes may influence skeletal muscle metabolism and function. Cellular nutritional requirements conditioned by metabolic abnormalities in heart failure are important considerations in the pathogenesis of the skeletal and cardiac muscle dysfunction. A comprehensive restoration of adequate myocyte nutrition would seem to be essential to any therapeutic strategy designed to benefit patients suffering from this disease.

Authors+Show Affiliations

Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11085825

Citation

Sole, M J., and K N. Jeejeebhoy. "Conditioned Nutritional Requirements and the Pathogenesis and Treatment of Myocardial Failure." Current Opinion in Clinical Nutrition and Metabolic Care, vol. 3, no. 6, 2000, pp. 417-24.
Sole MJ, Jeejeebhoy KN. Conditioned nutritional requirements and the pathogenesis and treatment of myocardial failure. Curr Opin Clin Nutr Metab Care. 2000;3(6):417-24.
Sole, M. J., & Jeejeebhoy, K. N. (2000). Conditioned nutritional requirements and the pathogenesis and treatment of myocardial failure. Current Opinion in Clinical Nutrition and Metabolic Care, 3(6), pp. 417-24.
Sole MJ, Jeejeebhoy KN. Conditioned Nutritional Requirements and the Pathogenesis and Treatment of Myocardial Failure. Curr Opin Clin Nutr Metab Care. 2000;3(6):417-24. PubMed PMID: 11085825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conditioned nutritional requirements and the pathogenesis and treatment of myocardial failure. AU - Sole,M J, AU - Jeejeebhoy,K N, PY - 2000/11/21/pubmed PY - 2001/3/7/medline PY - 2000/11/21/entrez SP - 417 EP - 24 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 3 IS - 6 N2 - The majority of symptomatic patients with congestive heart failure have been shown to be significantly malnourished. Myocardial and skeletal muscle energy reserves are also diminished. Total daily energy expenditure in these patients is less than that in control individuals, and high protein-calorie feeds do not reverse the abnormalities; thus, the wasting that occurs in patients with congestive heart failure is metabolic rather than because of negative protein-calorie balance. Several specific deficiencies have been found in the failing myocardium: a reduction in the content of L-carnitine, coenzyme Q10, creatine and thiamine, nutrient cofactors that are important for myocardial energy production; a relative deficiency of taurine, an amino acid that is integral to the modulation of intracellular calcium levels; and an increase in myocardial oxidative stress, and a reduction of both endogenous and exogenous antioxidant defences. In addition, these processes may influence skeletal muscle metabolism and function. Cellular nutritional requirements conditioned by metabolic abnormalities in heart failure are important considerations in the pathogenesis of the skeletal and cardiac muscle dysfunction. A comprehensive restoration of adequate myocyte nutrition would seem to be essential to any therapeutic strategy designed to benefit patients suffering from this disease. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/11085825/Conditioned_nutritional_requirements_and_the_pathogenesis_and_treatment_of_myocardial_failure_ L2 - http://Insights.ovid.com/pubmed?pmid=11085825 DB - PRIME DP - Unbound Medicine ER -