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Absorption of chlorogenic acid and caffeic acid in rats after oral administration.
J Agric Food Chem. 2000 Nov; 48(11):5496-500.JA

Abstract

Absorption of orally administered chlorogenic acid (5-caffeoylquinic acid) and caffeic acid in rats was studied to obtain plasma pharmacokinetic profiles of their metabolites. Rats were administered 700 micromol/kg body weight of chlorogenic or caffeic acid, and blood was collected from the tail for 6 h after administration. Ingested caffeic acid was absorbed from the alimentary tract and was present in the rat blood circulation in the form of various metabolites. On the other hand, only traces of metabolites, supposedly caffeic and ferulic acids conjugates, were detected in rat plasma for 6 h after chlorogenic acid administration. Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid administration. These results suggest that chlorogenic acid is not well absorbed from the digestive tract, unlike caffeic acid, and subject to almost no structural changes to the easily absorbed forms.

Authors+Show Affiliations

National Research Institute of Vegetables, Ornamental Plants and Tea, Ano, Mie 514-2392, Japan. azumak@nivot.affrc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11087508

Citation

Azuma, K, et al. "Absorption of Chlorogenic Acid and Caffeic Acid in Rats After Oral Administration." Journal of Agricultural and Food Chemistry, vol. 48, no. 11, 2000, pp. 5496-500.
Azuma K, Ippoushi K, Nakayama M, et al. Absorption of chlorogenic acid and caffeic acid in rats after oral administration. J Agric Food Chem. 2000;48(11):5496-500.
Azuma, K., Ippoushi, K., Nakayama, M., Ito, H., Higashio, H., & Terao, J. (2000). Absorption of chlorogenic acid and caffeic acid in rats after oral administration. Journal of Agricultural and Food Chemistry, 48(11), 5496-500.
Azuma K, et al. Absorption of Chlorogenic Acid and Caffeic Acid in Rats After Oral Administration. J Agric Food Chem. 2000;48(11):5496-500. PubMed PMID: 11087508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Absorption of chlorogenic acid and caffeic acid in rats after oral administration. AU - Azuma,K, AU - Ippoushi,K, AU - Nakayama,M, AU - Ito,H, AU - Higashio,H, AU - Terao,J, PY - 2000/11/23/pubmed PY - 2001/2/28/medline PY - 2000/11/23/entrez SP - 5496 EP - 500 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 48 IS - 11 N2 - Absorption of orally administered chlorogenic acid (5-caffeoylquinic acid) and caffeic acid in rats was studied to obtain plasma pharmacokinetic profiles of their metabolites. Rats were administered 700 micromol/kg body weight of chlorogenic or caffeic acid, and blood was collected from the tail for 6 h after administration. Ingested caffeic acid was absorbed from the alimentary tract and was present in the rat blood circulation in the form of various metabolites. On the other hand, only traces of metabolites, supposedly caffeic and ferulic acids conjugates, were detected in rat plasma for 6 h after chlorogenic acid administration. Chlorogenic acid and small amounts of caffeic acid were found in the small intestine for 6 h after chlorogenic acid administration. These results suggest that chlorogenic acid is not well absorbed from the digestive tract, unlike caffeic acid, and subject to almost no structural changes to the easily absorbed forms. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/11087508/Absorption_of_chlorogenic_acid_and_caffeic_acid_in_rats_after_oral_administration_ L2 - https://doi.org/10.1021/jf000483q DB - PRIME DP - Unbound Medicine ER -