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Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study.
Neurology. 2000 Nov 14; 55(9):1350-8.Neur

Abstract

OBJECTIVE

To study the association of PD with preceding smoking, alcohol, and coffee consumption using a case-control design.

METHODS

The authors used the medical records linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, during the years 1976 to 1995. Each incident case was matched by age (+/-1 year) and sex to a general population control subject. The authors reviewed the complete medical records of cases and control subjects to abstract exposure information.

RESULTS

For coffee consumption, the authors found an OR of 0.35 (95% CI = 0.16 to 0.78, p = 0.01), a dose-effect trend (p = 0.003), and a later age at PD onset in cases who drank coffee compared with those who never did (median 72 versus 64 years; p = 0.0002). The inverse association with coffee remained significant after adjustment for education, smoking, and alcohol drinking and was restricted to PD cases with onset at age <72 years and to men. The OR for cigarette smoking was 0.69 (95% CI = 0.45 to 1.08, p = 0.1). The authors found no association between PD and alcohol consumption. Extreme or unusual behaviors such as tobacco chewing or snuff use and a diagnosis of alcoholism were significantly more common in control subjects than cases.

CONCLUSIONS

These findings suggest an inverse association between coffee drinking and PD; however, this association does not imply that coffee has a direct protective effect against PD. Alternative explanations for the association should be considered.

Authors+Show Affiliations

Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11087780

Citation

Benedetti, M D., et al. "Smoking, Alcohol, and Coffee Consumption Preceding Parkinson's Disease: a Case-control Study." Neurology, vol. 55, no. 9, 2000, pp. 1350-8.
Benedetti MD, Bower JH, Maraganore DM, et al. Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study. Neurology. 2000;55(9):1350-8.
Benedetti, M. D., Bower, J. H., Maraganore, D. M., McDonnell, S. K., Peterson, B. J., Ahlskog, J. E., Schaid, D. J., & Rocca, W. A. (2000). Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study. Neurology, 55(9), 1350-8.
Benedetti MD, et al. Smoking, Alcohol, and Coffee Consumption Preceding Parkinson's Disease: a Case-control Study. Neurology. 2000 Nov 14;55(9):1350-8. PubMed PMID: 11087780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study. AU - Benedetti,M D, AU - Bower,J H, AU - Maraganore,D M, AU - McDonnell,S K, AU - Peterson,B J, AU - Ahlskog,J E, AU - Schaid,D J, AU - Rocca,W A, PY - 2000/11/23/pubmed PY - 2001/2/28/medline PY - 2000/11/23/entrez SP - 1350 EP - 8 JF - Neurology JO - Neurology VL - 55 IS - 9 N2 - OBJECTIVE: To study the association of PD with preceding smoking, alcohol, and coffee consumption using a case-control design. METHODS: The authors used the medical records linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, during the years 1976 to 1995. Each incident case was matched by age (+/-1 year) and sex to a general population control subject. The authors reviewed the complete medical records of cases and control subjects to abstract exposure information. RESULTS: For coffee consumption, the authors found an OR of 0.35 (95% CI = 0.16 to 0.78, p = 0.01), a dose-effect trend (p = 0.003), and a later age at PD onset in cases who drank coffee compared with those who never did (median 72 versus 64 years; p = 0.0002). The inverse association with coffee remained significant after adjustment for education, smoking, and alcohol drinking and was restricted to PD cases with onset at age <72 years and to men. The OR for cigarette smoking was 0.69 (95% CI = 0.45 to 1.08, p = 0.1). The authors found no association between PD and alcohol consumption. Extreme or unusual behaviors such as tobacco chewing or snuff use and a diagnosis of alcoholism were significantly more common in control subjects than cases. CONCLUSIONS: These findings suggest an inverse association between coffee drinking and PD; however, this association does not imply that coffee has a direct protective effect against PD. Alternative explanations for the association should be considered. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/11087780/Smoking_alcohol_and_coffee_consumption_preceding_Parkinson's_disease:_a_case_control_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&amp;pmid=11087780 DB - PRIME DP - Unbound Medicine ER -