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Effect of adenovirus type 1 and influenza A virus on Streptococcus pneumoniae nasopharyngeal colonization and otitis media in the chinchilla.
Ann Otol Rhinol Laryngol. 2000 Nov; 109(11):1021-7.AO

Abstract

Considerable evidence has implicated respiratory tract virus potentiation of bacterial adherence, colonization, and superinfection as a significant factor contributing to the pathogenesis of otitis media (OM). Influenza A and B viruses, adenovirus, and respiratory syncytial virus are the primary respiratory tract viruses associated with this disease. Investigations have established a dramatic increase in the development of experimental OM in chinchillas co-inoculated with influenza A virus and Streptococcus pneumoniae (Spn). The mechanism underlying this phenomenon was suggested to involve, in part, viral compromise of eustachian tube mucosal integrity and function. This study was designed to assess and compare the effect of adenovirus and influenza A virus infection on adherence, the kinetics of colonization, and invasion of the middle ear by Spn in the chinchilla model of OM. Cohorts were inoculated intranasally with adenovirus type 1 or influenza A virus, and then inoculated intranasally 7 days later with Spn 6A. All cohorts were observed over a 14-day period after challenge with Spn, and the incidence and severity of OM were assessed by several methods, including culture of the nasopharynx and middle ear effusions. The data indicated that influenza A virus promotes a significant increase in nasopharyngeal colonization by Spn, an increased incidence and severity of OM, and a sustained presence of Spn in the effusions. Adenovirus infection, however, did not enhance colonization by Spn or result in an increased incidence or severity of OM.

Authors+Show Affiliations

Department of Otolaryngology, College of Medicine and Public Health, The Ohio State University, Columbus 43210-1282, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11089992

Citation

Tong, H H., et al. "Effect of Adenovirus Type 1 and Influenza a Virus On Streptococcus Pneumoniae Nasopharyngeal Colonization and Otitis Media in the Chinchilla." The Annals of Otology, Rhinology, and Laryngology, vol. 109, no. 11, 2000, pp. 1021-7.
Tong HH, Fisher LM, Kosunick GM, et al. Effect of adenovirus type 1 and influenza A virus on Streptococcus pneumoniae nasopharyngeal colonization and otitis media in the chinchilla. Ann Otol Rhinol Laryngol. 2000;109(11):1021-7.
Tong, H. H., Fisher, L. M., Kosunick, G. M., & DeMaria, T. F. (2000). Effect of adenovirus type 1 and influenza A virus on Streptococcus pneumoniae nasopharyngeal colonization and otitis media in the chinchilla. The Annals of Otology, Rhinology, and Laryngology, 109(11), 1021-7.
Tong HH, et al. Effect of Adenovirus Type 1 and Influenza a Virus On Streptococcus Pneumoniae Nasopharyngeal Colonization and Otitis Media in the Chinchilla. Ann Otol Rhinol Laryngol. 2000;109(11):1021-7. PubMed PMID: 11089992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of adenovirus type 1 and influenza A virus on Streptococcus pneumoniae nasopharyngeal colonization and otitis media in the chinchilla. AU - Tong,H H, AU - Fisher,L M, AU - Kosunick,G M, AU - DeMaria,T F, PY - 2000/11/23/pubmed PY - 2001/2/28/medline PY - 2000/11/23/entrez SP - 1021 EP - 7 JF - The Annals of otology, rhinology, and laryngology JO - Ann Otol Rhinol Laryngol VL - 109 IS - 11 N2 - Considerable evidence has implicated respiratory tract virus potentiation of bacterial adherence, colonization, and superinfection as a significant factor contributing to the pathogenesis of otitis media (OM). Influenza A and B viruses, adenovirus, and respiratory syncytial virus are the primary respiratory tract viruses associated with this disease. Investigations have established a dramatic increase in the development of experimental OM in chinchillas co-inoculated with influenza A virus and Streptococcus pneumoniae (Spn). The mechanism underlying this phenomenon was suggested to involve, in part, viral compromise of eustachian tube mucosal integrity and function. This study was designed to assess and compare the effect of adenovirus and influenza A virus infection on adherence, the kinetics of colonization, and invasion of the middle ear by Spn in the chinchilla model of OM. Cohorts were inoculated intranasally with adenovirus type 1 or influenza A virus, and then inoculated intranasally 7 days later with Spn 6A. All cohorts were observed over a 14-day period after challenge with Spn, and the incidence and severity of OM were assessed by several methods, including culture of the nasopharynx and middle ear effusions. The data indicated that influenza A virus promotes a significant increase in nasopharyngeal colonization by Spn, an increased incidence and severity of OM, and a sustained presence of Spn in the effusions. Adenovirus infection, however, did not enhance colonization by Spn or result in an increased incidence or severity of OM. SN - 0003-4894 UR - https://www.unboundmedicine.com/medline/citation/11089992/Effect_of_adenovirus_type_1_and_influenza_A_virus_on_Streptococcus_pneumoniae_nasopharyngeal_colonization_and_otitis_media_in_the_chinchilla_ L2 - https://journals.sagepub.com/doi/10.1177/000348940010901106?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -