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Plasma vasopressin and aldosterone responses to oral and intravenous saline rehydration.
J Appl Physiol (1985). 2000 Dec; 89(6):2117-22.JA

Abstract

This investigation examined plasma arginine vasopressin (AVP) and aldosterone (Ald) responses to 1) oral and intravenous (IV) methods of rehydration (Rh) and 2) different IV Rh osmotic loads. We hypothesized that AVP and Ald responses would be similar between IV and oral Rh and that the greater osmolality and sodium concentration of a 0.9% IV saline treatment would stimulate a greater AVP response compared with a 0.45% IV saline treatment. On four occasions, eight men (age: 22.1 +/- 0.8 yr; height: 179.6 +/- 1.5 cm; weight: 73.6 +/- 2.5 kg; maximum O(2) consumption: 57.9 +/- 1.6 ml. kg(-1). min(-1), body fat: 7.7 +/- 0.9%) performed a dehydration (Dh) protocol (33 degrees C) to establish a 4-5% reduction in body weight. After Dh, subjects underwent each of three randomly assigned Rh (back to -2% body wt) treatments (0.9 and 0.45% IV saline, 0.45% oral saline) and a no Rh treatment during the first 45 min of a 100-min rest period. Blood samples were obtained pre-Dh, immediately post-Dh, and at 15, 35, and 55 min post-Rh. Before Dh, plasma AVP and Ald were not different among treatments but were significantly elevated post-Dh. In general, at 15, 35, and 55 min post-Rh, AVP, Ald, osmolality, and plasma volume shifts did not differ between IV and oral fluid replacement. These results demonstrated that the manner in which plasma AVP and Ald responded to oral and IV Rh or to different sodium concentrations (0.9 vs. 0.45%) was not different given the degree of Dh (-4.5% body wt) and Rh and amount of time after Rh (55 min).

Authors+Show Affiliations

Department of Kinesiology, The University of New Hampshire, Durham, New Hampshire 03824, USA. RWK@hopper.unh.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11090557

Citation

Kenefick, R W., et al. "Plasma Vasopressin and Aldosterone Responses to Oral and Intravenous Saline Rehydration." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 89, no. 6, 2000, pp. 2117-22.
Kenefick RW, Maresh CM, Armstrong LE, et al. Plasma vasopressin and aldosterone responses to oral and intravenous saline rehydration. J Appl Physiol. 2000;89(6):2117-22.
Kenefick, R. W., Maresh, C. M., Armstrong, L. E., Castellani, J. W., Riebe, D., Echegaray, M. E., & Kavorous, S. A. (2000). Plasma vasopressin and aldosterone responses to oral and intravenous saline rehydration. Journal of Applied Physiology (Bethesda, Md. : 1985), 89(6), 2117-22.
Kenefick RW, et al. Plasma Vasopressin and Aldosterone Responses to Oral and Intravenous Saline Rehydration. J Appl Physiol. 2000;89(6):2117-22. PubMed PMID: 11090557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma vasopressin and aldosterone responses to oral and intravenous saline rehydration. AU - Kenefick,R W, AU - Maresh,C M, AU - Armstrong,L E, AU - Castellani,J W, AU - Riebe,D, AU - Echegaray,M E, AU - Kavorous,S A, PY - 2000/11/25/pubmed PY - 2001/2/28/medline PY - 2000/11/25/entrez SP - 2117 EP - 22 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 89 IS - 6 N2 - This investigation examined plasma arginine vasopressin (AVP) and aldosterone (Ald) responses to 1) oral and intravenous (IV) methods of rehydration (Rh) and 2) different IV Rh osmotic loads. We hypothesized that AVP and Ald responses would be similar between IV and oral Rh and that the greater osmolality and sodium concentration of a 0.9% IV saline treatment would stimulate a greater AVP response compared with a 0.45% IV saline treatment. On four occasions, eight men (age: 22.1 +/- 0.8 yr; height: 179.6 +/- 1.5 cm; weight: 73.6 +/- 2.5 kg; maximum O(2) consumption: 57.9 +/- 1.6 ml. kg(-1). min(-1), body fat: 7.7 +/- 0.9%) performed a dehydration (Dh) protocol (33 degrees C) to establish a 4-5% reduction in body weight. After Dh, subjects underwent each of three randomly assigned Rh (back to -2% body wt) treatments (0.9 and 0.45% IV saline, 0.45% oral saline) and a no Rh treatment during the first 45 min of a 100-min rest period. Blood samples were obtained pre-Dh, immediately post-Dh, and at 15, 35, and 55 min post-Rh. Before Dh, plasma AVP and Ald were not different among treatments but were significantly elevated post-Dh. In general, at 15, 35, and 55 min post-Rh, AVP, Ald, osmolality, and plasma volume shifts did not differ between IV and oral fluid replacement. These results demonstrated that the manner in which plasma AVP and Ald responded to oral and IV Rh or to different sodium concentrations (0.9 vs. 0.45%) was not different given the degree of Dh (-4.5% body wt) and Rh and amount of time after Rh (55 min). SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/11090557/Plasma_vasopressin_and_aldosterone_responses_to_oral_and_intravenous_saline_rehydration_ L2 - http://journals.physiology.org/doi/full/10.1152/jappl.2000.89.6.2117?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -