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The effects of aminotriazole and acetaldehyde on an ethanol drug discrimination with a conditioned taste aversion procedure.
Alcohol. 2000 Jul; 21(3):279-85.A

Abstract

The present study was designed to investigate whether acetaldehyde shares stimulus properties with ethanol using the conditioned taste aversion (CTA) baseline of drug discrimination learning. Animals were trained to discriminate ethanol (0.8 g/kg, i.p.) from saline using 11 consecutive cycles consisting of a pairing day and three nonpairing days. On pairing days, all animals were injected with ethanol 30 min prior to a 20-min limited access to a saccharin solution (0.1% w/v) and then immediately injected with either LiCl (0.15 M, 1.8 meq) or distilled water. On the three following nonpairing days, animals were injected with saline and 30 min later presented with the same saccharin solution for 20 min. No injections followed on these nonpairing days. Results showed that animals acquired discriminative stimulus control for ethanol after seven pairings. Pretreatment with the catalase inhibitor did not alter the discriminative control for ethanol. Generalization tests revealed that acetaldehyde substituted for ethanol at a dose of 0.3 g/kg. The results of the present study suggest that catalase inhibition did not reverse or alter the discriminative stimulus effects of ethanol. However, generalization tests showed that acetaldehyde (0.3 g/kg) will substitute for ethanol suggesting that these two drugs share some similar properties.

Authors+Show Affiliations

Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard, W., H-1013, H3G 1M8, Montreal, Quebec, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11091032

Citation

Redila, V A., et al. "The Effects of Aminotriazole and Acetaldehyde On an Ethanol Drug Discrimination With a Conditioned Taste Aversion Procedure." Alcohol (Fayetteville, N.Y.), vol. 21, no. 3, 2000, pp. 279-85.
Redila VA, Smith BR, Amit Z. The effects of aminotriazole and acetaldehyde on an ethanol drug discrimination with a conditioned taste aversion procedure. Alcohol. 2000;21(3):279-85.
Redila, V. A., Smith, B. R., & Amit, Z. (2000). The effects of aminotriazole and acetaldehyde on an ethanol drug discrimination with a conditioned taste aversion procedure. Alcohol (Fayetteville, N.Y.), 21(3), 279-85.
Redila VA, Smith BR, Amit Z. The Effects of Aminotriazole and Acetaldehyde On an Ethanol Drug Discrimination With a Conditioned Taste Aversion Procedure. Alcohol. 2000;21(3):279-85. PubMed PMID: 11091032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of aminotriazole and acetaldehyde on an ethanol drug discrimination with a conditioned taste aversion procedure. AU - Redila,V A, AU - Smith,B R, AU - Amit,Z, PY - 2000/11/25/pubmed PY - 2001/2/28/medline PY - 2000/11/25/entrez SP - 279 EP - 85 JF - Alcohol (Fayetteville, N.Y.) JO - Alcohol VL - 21 IS - 3 N2 - The present study was designed to investigate whether acetaldehyde shares stimulus properties with ethanol using the conditioned taste aversion (CTA) baseline of drug discrimination learning. Animals were trained to discriminate ethanol (0.8 g/kg, i.p.) from saline using 11 consecutive cycles consisting of a pairing day and three nonpairing days. On pairing days, all animals were injected with ethanol 30 min prior to a 20-min limited access to a saccharin solution (0.1% w/v) and then immediately injected with either LiCl (0.15 M, 1.8 meq) or distilled water. On the three following nonpairing days, animals were injected with saline and 30 min later presented with the same saccharin solution for 20 min. No injections followed on these nonpairing days. Results showed that animals acquired discriminative stimulus control for ethanol after seven pairings. Pretreatment with the catalase inhibitor did not alter the discriminative control for ethanol. Generalization tests revealed that acetaldehyde substituted for ethanol at a dose of 0.3 g/kg. The results of the present study suggest that catalase inhibition did not reverse or alter the discriminative stimulus effects of ethanol. However, generalization tests showed that acetaldehyde (0.3 g/kg) will substitute for ethanol suggesting that these two drugs share some similar properties. SN - 0741-8329 UR - https://www.unboundmedicine.com/medline/citation/11091032/The_effects_of_aminotriazole_and_acetaldehyde_on_an_ethanol_drug_discrimination_with_a_conditioned_taste_aversion_procedure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0741-8329(00)00096-3 DB - PRIME DP - Unbound Medicine ER -