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Hydration of sickle erythrocytes using a herbal extract (Pfaffia paniculata) in vitro.
Br J Haematol. 2000 Oct; 111(1):359-62.BJ

Abstract

Pfaffia paniculata (PP) is a perennial wild plant that grows in South America. Its root powder has been used by South American Indians for a variety of ailments and has been reported to have a salutary effect on sickle cell disease in Brazil. Its mechanism of action, however, is unknown. In this report, we present experimental data showing that PP improves the deformability of sickle cells, increases their Na+ content and their mean corpuscular volume (MCV). These findings indicate that PP functions as a sodium ionophore on sickle cells and improves their hydration status and rheological properties.

Authors+Show Affiliations

Ballas SK
Cardeza Foundation for Hematologic Research, Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA. Samir.Ballas@mail.tju.edu

MeSH

Anemia, Sickle CellBrazilErythrocyte DeformabilityErythrocyte IndicesErythrocytes, AbnormalHumansIonophoresOsmolar ConcentrationPlant ExtractsPlants, MedicinalSodium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11091225

Citation

Ballas, S K.. "Hydration of Sickle Erythrocytes Using a Herbal Extract (Pfaffia Paniculata) in Vitro." British Journal of Haematology, vol. 111, no. 1, 2000, pp. 359-62.
Ballas SK. Hydration of sickle erythrocytes using a herbal extract (Pfaffia paniculata) in vitro. Br J Haematol. 2000;111(1):359-62.
Ballas, S. K. (2000). Hydration of sickle erythrocytes using a herbal extract (Pfaffia paniculata) in vitro. British Journal of Haematology, 111(1), 359-62.
Ballas SK. Hydration of Sickle Erythrocytes Using a Herbal Extract (Pfaffia Paniculata) in Vitro. Br J Haematol. 2000;111(1):359-62. PubMed PMID: 11091225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydration of sickle erythrocytes using a herbal extract (Pfaffia paniculata) in vitro. A1 - Ballas,S K, PY - 2000/11/25/pubmed PY - 2001/2/28/medline PY - 2000/11/25/entrez SP - 359 EP - 62 JF - British journal of haematology JO - Br J Haematol VL - 111 IS - 1 N2 - Pfaffia paniculata (PP) is a perennial wild plant that grows in South America. Its root powder has been used by South American Indians for a variety of ailments and has been reported to have a salutary effect on sickle cell disease in Brazil. Its mechanism of action, however, is unknown. In this report, we present experimental data showing that PP improves the deformability of sickle cells, increases their Na+ content and their mean corpuscular volume (MCV). These findings indicate that PP functions as a sodium ionophore on sickle cells and improves their hydration status and rheological properties. SN - 0007-1048 UR - https://www.unboundmedicine.com/medline/citation/11091225/Hydration_of_sickle_erythrocytes_using_a_herbal_extract__Pfaffia_paniculata__in_vitro_ DB - PRIME DP - Unbound Medicine ER -