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Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women.
Metabolism. 2000 Nov; 49(11):1440-3.M

Abstract

Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --> T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease. A controlled metabolic study (14 weeks) using a depletion/repletion protocol was performed in women (aged 60 to 85 years, N = 33) to provide age-specific data on the effects of the MTHFR mutation on SF and tHcy status. Subjects consumed a moderately folate-deplete diet (118 microg/d) for 7 weeks, followed by 7 weeks of folate repletion with 200 or 415 microg/d provided as two different treatments. Following folate depletion, the mean SF concentration was lower for homozygous (P = .017) versus heterozygous subjects. Homozygotes for the 677C --> T mutation showed a higher (P = .015) percent increase in plasma tHcy (44%) than heterozygous (20%) or normal (15%) subjects. At week 7, the mean plasma tHcy concentration was higher in homozygous subjects (12.5 +/- 5.3 micromol/L, mean +/- SD) versus the heterozygous (10.8 +/- 3.8 micromol/L, P = .008) or normal (11.3 +/- 2.7 micromol/L, P = .001) genotype groups. Following folate repletion, plasma tHcy concentrations were not different between genotype groups, despite a higher (P < .016) SF concentration in subjects with the homozygous genotype. These data suggest that older women who are homozygous for the MTHFR 677C --> T mutation may be at risk for greater elevations in plasma tHcy in response to moderately low folate intake as compared with individuals with the normal or heterozygous genotypes.

Authors+Show Affiliations

Food Science and Human Nutrition Department, College of Agricultural and Life Sciences, University of Florida, Gainesville 32611-0370, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11092508

Citation

Kauwell, G P., et al. "Methylenetetrahydrofolate Reductase Mutation (677C-->T) Negatively Influences Plasma Homocysteine Response to Marginal Folate Intake in Elderly Women." Metabolism: Clinical and Experimental, vol. 49, no. 11, 2000, pp. 1440-3.
Kauwell GP, Wilsky CE, Cerda JJ, et al. Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women. Metab Clin Exp. 2000;49(11):1440-3.
Kauwell, G. P., Wilsky, C. E., Cerda, J. J., Herrlinger-Garcia, K., Hutson, A. D., Theriaque, D. W., Boddie, A., Rampersaud, G. C., & Bailey, L. B. (2000). Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women. Metabolism: Clinical and Experimental, 49(11), 1440-3.
Kauwell GP, et al. Methylenetetrahydrofolate Reductase Mutation (677C-->T) Negatively Influences Plasma Homocysteine Response to Marginal Folate Intake in Elderly Women. Metab Clin Exp. 2000;49(11):1440-3. PubMed PMID: 11092508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women. AU - Kauwell,G P, AU - Wilsky,C E, AU - Cerda,J J, AU - Herrlinger-Garcia,K, AU - Hutson,A D, AU - Theriaque,D W, AU - Boddie,A, AU - Rampersaud,G C, AU - Bailey,L B, PY - 2000/11/25/pubmed PY - 2001/2/28/medline PY - 2000/11/25/entrez SP - 1440 EP - 3 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 49 IS - 11 N2 - Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --> T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease. A controlled metabolic study (14 weeks) using a depletion/repletion protocol was performed in women (aged 60 to 85 years, N = 33) to provide age-specific data on the effects of the MTHFR mutation on SF and tHcy status. Subjects consumed a moderately folate-deplete diet (118 microg/d) for 7 weeks, followed by 7 weeks of folate repletion with 200 or 415 microg/d provided as two different treatments. Following folate depletion, the mean SF concentration was lower for homozygous (P = .017) versus heterozygous subjects. Homozygotes for the 677C --> T mutation showed a higher (P = .015) percent increase in plasma tHcy (44%) than heterozygous (20%) or normal (15%) subjects. At week 7, the mean plasma tHcy concentration was higher in homozygous subjects (12.5 +/- 5.3 micromol/L, mean +/- SD) versus the heterozygous (10.8 +/- 3.8 micromol/L, P = .008) or normal (11.3 +/- 2.7 micromol/L, P = .001) genotype groups. Following folate repletion, plasma tHcy concentrations were not different between genotype groups, despite a higher (P < .016) SF concentration in subjects with the homozygous genotype. These data suggest that older women who are homozygous for the MTHFR 677C --> T mutation may be at risk for greater elevations in plasma tHcy in response to moderately low folate intake as compared with individuals with the normal or heterozygous genotypes. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/11092508/Methylenetetrahydrofolate_reductase_mutation__677C__>T__negatively_influences_plasma_homocysteine_response_to_marginal_folate_intake_in_elderly_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(00)38227-0 DB - PRIME DP - Unbound Medicine ER -