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The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization.
Int J Fertil Womens Med. 2000 Sep-Oct; 45(5):314-20.IJ

Abstract

OBJECTIVE

To examine the presence of reactive oxygen species (ROS) in the follicular fluid of women undergoing in vitro fertilization (IVF) and identify its role in pregnancy outcome.

STUDY DESIGN

In this prospective study, ROS and total antioxidant capacity (TAC) levels were measured by the chemiluminescence method in the follicular fluid of 53 women. Age, number of oocytes recovered, percentage of oocytes fertilized, ROS and TAC levels were compared in women who did and did not become pregnant.

RESULTS

Patients who become pregnant had significantly higher log-transformed ROS levels (1.01 +/- 0.14, P = 0.031 than those who did not (0.69 +/- 0.08). Women with endometriosis or male factor infertility who became pregnant had significantly higher ROS levels (1.44 +/- 0.23 and 1.31 +/- 0.19) than those who did not (0.60 +/- 0.17 and 0.67 +/- 0.16; P < .006 and P < .01).

CONCLUSION

Follicular fluid ROS, at low concentrations, may be a potential marker for predicting success in IVF patients.

Authors+Show Affiliations

Center for Advanced Research in Human Reproduction and Infertility, Department of Gynecology and Obstetrics, The Cleveland Clinic Foundation, Ohio 44195, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11092702

Citation

Attaran, M, et al. "The Effect of Follicular Fluid Reactive Oxygen Species On the Outcome of in Vitro Fertilization." International Journal of Fertility and Women's Medicine, vol. 45, no. 5, 2000, pp. 314-20.
Attaran M, Pasqualotto E, Falcone T, et al. The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization. Int J Fertil Womens Med. 2000;45(5):314-20.
Attaran, M., Pasqualotto, E., Falcone, T., Goldberg, J. M., Miller, K. F., Agarwal, A., & Sharma, R. K. (2000). The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization. International Journal of Fertility and Women's Medicine, 45(5), 314-20.
Attaran M, et al. The Effect of Follicular Fluid Reactive Oxygen Species On the Outcome of in Vitro Fertilization. Int J Fertil Womens Med. 2000;45(5):314-20. PubMed PMID: 11092702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization. AU - Attaran,M, AU - Pasqualotto,E, AU - Falcone,T, AU - Goldberg,J M, AU - Miller,K F, AU - Agarwal,A, AU - Sharma,R K, PY - 2000/11/25/pubmed PY - 2001/6/2/medline PY - 2000/11/25/entrez SP - 314 EP - 20 JF - International journal of fertility and women's medicine JO - Int J Fertil Womens Med VL - 45 IS - 5 N2 - OBJECTIVE: To examine the presence of reactive oxygen species (ROS) in the follicular fluid of women undergoing in vitro fertilization (IVF) and identify its role in pregnancy outcome. STUDY DESIGN: In this prospective study, ROS and total antioxidant capacity (TAC) levels were measured by the chemiluminescence method in the follicular fluid of 53 women. Age, number of oocytes recovered, percentage of oocytes fertilized, ROS and TAC levels were compared in women who did and did not become pregnant. RESULTS: Patients who become pregnant had significantly higher log-transformed ROS levels (1.01 +/- 0.14, P = 0.031 than those who did not (0.69 +/- 0.08). Women with endometriosis or male factor infertility who became pregnant had significantly higher ROS levels (1.44 +/- 0.23 and 1.31 +/- 0.19) than those who did not (0.60 +/- 0.17 and 0.67 +/- 0.16; P < .006 and P < .01). CONCLUSION: Follicular fluid ROS, at low concentrations, may be a potential marker for predicting success in IVF patients. SN - 1534-892X UR - https://www.unboundmedicine.com/medline/citation/11092702/The_effect_of_follicular_fluid_reactive_oxygen_species_on_the_outcome_of_in_vitro_fertilization_ DB - PRIME DP - Unbound Medicine ER -