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Association between HLA-DRB1*15 and secondary Sjögren's syndrome in patients with rheumatoid arthritis.
J Rheumatol. 2000 Nov; 27(11):2611-6.JR

Abstract

OBJECTIVE

To examine the relationship between HLA-DRB1 alleles and the clinical expression of the secondary form of Sjogren's syndrome (SS) in patients with rheumatoid arthritis (RA).

METHODS

Typing of HLA-DRB1 alleles was carried out by molecular based techniques on DNA obtained from a population of patients with RA from Lugo in northwestern Spain. Patients were diagnosed according to the 1987 American College of Rheumatology criteria for RA, and comprised 137 seropositive and 42 seronegative individuals. Secondary SS was defined by xerostomia and keratoconjunctivitis sicca, supported by ophthalmologic examination. Patients were compared with 145 ethnically matched controls.

RESULTS

Twenty-two (12.3%) of the patients with RA also had secondary SS. The majority of these (19/22) were rheumatoid factor positive. Eleven (57.9%) of the seropositive patients with secondary SS carried an HLA-DRB1*15 allele compared with 28 (23.7%) seropositive patients without secondary SS (OR 4.4, 95% CI 1.5-13.6, pc = 0.014). In contrast, the frequency of DRB1*04 was reduced in seropositive patients with secondary SS compared to those without secondary SS, although this did not achieve significance after correction for multiple testing (OR 0.28, 95% CI 0.09-0.88, pc = 0.08). Of note, in individuals lacking the RA shared epitope (SE), DRB1*15 was found to be associated (OR 2.3, 95% CI 1.0-5.1, pc = 0.03) with RA in the absence of secondary SS. No differences were found between DRB1*15 positive and negative patients in terms of erosive disease, nodules, or rheumatoid factor positivity.

CONCLUSION

Secondary SS is associated with an increased frequency of HLA-DRB1*15 in seropositive patients with RA from northwestern Spain. HLA-DRB1*15 is also associated with RA in SE negative individuals without secondary SS, although the possibility that such patients will later develop SS cannot be ruled out. Further studies are needed to confirm whether the HLA-DRB1*15 association with secondary SS in RA is common to Spanish and other ethnic populations.

Authors+Show Affiliations

Staffordshire Rheumatology Centre, Stoke-on-Trent, England. d.l.mattey@keele.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11093441

Citation

Mattey, D L., et al. "Association Between HLA-DRB1*15 and Secondary Sjögren's Syndrome in Patients With Rheumatoid Arthritis." The Journal of Rheumatology, vol. 27, no. 11, 2000, pp. 2611-6.
Mattey DL, González-Gay MA, Hajeer AH, et al. Association between HLA-DRB1*15 and secondary Sjögren's syndrome in patients with rheumatoid arthritis. J Rheumatol. 2000;27(11):2611-6.
Mattey, D. L., González-Gay, M. A., Hajeer, A. H., Dababneh, A., Thomson, W., García-Porrúa, C., & Ollier, W. E. (2000). Association between HLA-DRB1*15 and secondary Sjögren's syndrome in patients with rheumatoid arthritis. The Journal of Rheumatology, 27(11), 2611-6.
Mattey DL, et al. Association Between HLA-DRB1*15 and Secondary Sjögren's Syndrome in Patients With Rheumatoid Arthritis. J Rheumatol. 2000;27(11):2611-6. PubMed PMID: 11093441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between HLA-DRB1*15 and secondary Sjögren's syndrome in patients with rheumatoid arthritis. AU - Mattey,D L, AU - González-Gay,M A, AU - Hajeer,A H, AU - Dababneh,A, AU - Thomson,W, AU - García-Porrúa,C, AU - Ollier,W E, PY - 2000/11/28/pubmed PY - 2001/4/3/medline PY - 2000/11/28/entrez SP - 2611 EP - 6 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 27 IS - 11 N2 - OBJECTIVE: To examine the relationship between HLA-DRB1 alleles and the clinical expression of the secondary form of Sjogren's syndrome (SS) in patients with rheumatoid arthritis (RA). METHODS: Typing of HLA-DRB1 alleles was carried out by molecular based techniques on DNA obtained from a population of patients with RA from Lugo in northwestern Spain. Patients were diagnosed according to the 1987 American College of Rheumatology criteria for RA, and comprised 137 seropositive and 42 seronegative individuals. Secondary SS was defined by xerostomia and keratoconjunctivitis sicca, supported by ophthalmologic examination. Patients were compared with 145 ethnically matched controls. RESULTS: Twenty-two (12.3%) of the patients with RA also had secondary SS. The majority of these (19/22) were rheumatoid factor positive. Eleven (57.9%) of the seropositive patients with secondary SS carried an HLA-DRB1*15 allele compared with 28 (23.7%) seropositive patients without secondary SS (OR 4.4, 95% CI 1.5-13.6, pc = 0.014). In contrast, the frequency of DRB1*04 was reduced in seropositive patients with secondary SS compared to those without secondary SS, although this did not achieve significance after correction for multiple testing (OR 0.28, 95% CI 0.09-0.88, pc = 0.08). Of note, in individuals lacking the RA shared epitope (SE), DRB1*15 was found to be associated (OR 2.3, 95% CI 1.0-5.1, pc = 0.03) with RA in the absence of secondary SS. No differences were found between DRB1*15 positive and negative patients in terms of erosive disease, nodules, or rheumatoid factor positivity. CONCLUSION: Secondary SS is associated with an increased frequency of HLA-DRB1*15 in seropositive patients with RA from northwestern Spain. HLA-DRB1*15 is also associated with RA in SE negative individuals without secondary SS, although the possibility that such patients will later develop SS cannot be ruled out. Further studies are needed to confirm whether the HLA-DRB1*15 association with secondary SS in RA is common to Spanish and other ethnic populations. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/11093441/Association_between_HLA_DRB1_15_and_secondary_Sjögren's_syndrome_in_patients_with_rheumatoid_arthritis_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -