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IgA and IgG autoantibodies against alpha-fodrin as markers for Sjögren's syndrome. Systemic lupus erythematosus.
J Rheumatol. 2000 Nov; 27(11):2617-20.JR

Abstract

OBJECTIVE

To determine the prevalence of IgA and IgG autoantibodies against alpha-fodrin in patients with primary and secondary Sjögren's syndrome (SS) and controls.

METHODS

An ELISA detecting IgA and IgG antibodies against alpha-fodrin was developed. We examined the prevalence of IgA and IgG antibodies against alpha-fodrin in patients with primary and secondary SS, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) and blood donors.

RESULTS

IgA antibodies against alpha-fodrin were detected in 64% of patients with primary SS (n = 85), 47% of patients with secondary SS and SLE (n = 15), and 86% of patients with secondary SS and RA (n = 7). IgA autoantibodies against alpha-fodrin were detected in only one of 160 sera obtained from blood donors and in one of 50 and 2 of 12 sera obtained from SLE and RA patients without sicca syndrome, respectively. The prevalence of IgG antibodies against alpha-fodrin in SS was lower: they were detected in 55% of sera obtained from patients with primary SS, 40% of patients with secondary SS and SLE, and in 43% of patients with secondary SS and RA. Three of 160 sera from blood donors and one of 50 and 5 of 12 sera from SLE and RA patients without sicca syndrome, respectively, contained IgG antibodies against alpha-fodrin.

CONCLUSION

IgA rather than IgG antibodies against alpha-fodrin are specific for and frequently observed in primary and secondary SS and are useful markers for this autoimmune disorder.

Authors+Show Affiliations

Abteilung Klinische Immunologie, Medizinische Hochschule Hannover, Germany. witte.torsten@mh.hannover.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11093442

Citation

Witte, T, et al. "IgA and IgG Autoantibodies Against Alpha-fodrin as Markers for Sjögren's Syndrome. Systemic Lupus Erythematosus." The Journal of Rheumatology, vol. 27, no. 11, 2000, pp. 2617-20.
Witte T, Matthias T, Arnett FC, et al. IgA and IgG autoantibodies against alpha-fodrin as markers for Sjögren's syndrome. Systemic lupus erythematosus. J Rheumatol. 2000;27(11):2617-20.
Witte, T., Matthias, T., Arnett, F. C., Peter, H. H., Hartung, K., Sachse, C., Wigand, R., Braner, A., Kalden, J. R., Lakomek, H. J., & Schmidt, R. E. (2000). IgA and IgG autoantibodies against alpha-fodrin as markers for Sjögren's syndrome. Systemic lupus erythematosus. The Journal of Rheumatology, 27(11), 2617-20.
Witte T, et al. IgA and IgG Autoantibodies Against Alpha-fodrin as Markers for Sjögren's Syndrome. Systemic Lupus Erythematosus. J Rheumatol. 2000;27(11):2617-20. PubMed PMID: 11093442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgA and IgG autoantibodies against alpha-fodrin as markers for Sjögren's syndrome. Systemic lupus erythematosus. AU - Witte,T, AU - Matthias,T, AU - Arnett,F C, AU - Peter,H H, AU - Hartung,K, AU - Sachse,C, AU - Wigand,R, AU - Braner,A, AU - Kalden,J R, AU - Lakomek,H J, AU - Schmidt,R E, PY - 2000/11/28/pubmed PY - 2001/4/3/medline PY - 2000/11/28/entrez SP - 2617 EP - 20 JF - The Journal of rheumatology JO - J Rheumatol VL - 27 IS - 11 N2 - OBJECTIVE: To determine the prevalence of IgA and IgG autoantibodies against alpha-fodrin in patients with primary and secondary Sjögren's syndrome (SS) and controls. METHODS: An ELISA detecting IgA and IgG antibodies against alpha-fodrin was developed. We examined the prevalence of IgA and IgG antibodies against alpha-fodrin in patients with primary and secondary SS, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) and blood donors. RESULTS: IgA antibodies against alpha-fodrin were detected in 64% of patients with primary SS (n = 85), 47% of patients with secondary SS and SLE (n = 15), and 86% of patients with secondary SS and RA (n = 7). IgA autoantibodies against alpha-fodrin were detected in only one of 160 sera obtained from blood donors and in one of 50 and 2 of 12 sera obtained from SLE and RA patients without sicca syndrome, respectively. The prevalence of IgG antibodies against alpha-fodrin in SS was lower: they were detected in 55% of sera obtained from patients with primary SS, 40% of patients with secondary SS and SLE, and in 43% of patients with secondary SS and RA. Three of 160 sera from blood donors and one of 50 and 5 of 12 sera from SLE and RA patients without sicca syndrome, respectively, contained IgG antibodies against alpha-fodrin. CONCLUSION: IgA rather than IgG antibodies against alpha-fodrin are specific for and frequently observed in primary and secondary SS and are useful markers for this autoimmune disorder. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/11093442/IgA_and_IgG_autoantibodies_against_alpha_fodrin_as_markers_for_Sjögren's_syndrome__Systemic_lupus_erythematosus_ L2 - http://www.diseaseinfosearch.org/result/9373 DB - PRIME DP - Unbound Medicine ER -