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Searching for alternatives to heparin: sulfated fucans from marine invertebrates.
Trends Cardiovasc Med. 1999 Nov; 9(8):225-32.TC

Abstract

We describe a variety of sulfated polysaccharides with regular and well-defined structures which are useful tools for elucidating structure/biological function relationship. Several of these compounds have anticoagulant and antithrombotic activities. The most studied and promising polysaccharide is a fucosylated chondroitin sulfate, composed of a chondroitin sulfate-like backbone, substituted at position 3 of the beta-D-glucuronic acid with heavily sulfated fucose side chains. The anticoagulant activity of this polysaccharide is mediated by both antithrombin and heparin cofactor II; it has antithrombotic activity when targeted at the intrinsic coagulation pathway.

Authors+Show Affiliations

Laboratório de Tecido Conjuntivo, Hospital Universitário Clementino Fraga Filho and Departamento de Bioquímica Médica, Centro de Ciências da Saúde, Rio de Janeiro, Brazil.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

11094330

Citation

Mourão, P A., and M S. Pereira. "Searching for Alternatives to Heparin: Sulfated Fucans From Marine Invertebrates." Trends in Cardiovascular Medicine, vol. 9, no. 8, 1999, pp. 225-32.
Mourão PA, Pereira MS. Searching for alternatives to heparin: sulfated fucans from marine invertebrates. Trends Cardiovasc Med. 1999;9(8):225-32.
Mourão, P. A., & Pereira, M. S. (1999). Searching for alternatives to heparin: sulfated fucans from marine invertebrates. Trends in Cardiovascular Medicine, 9(8), 225-32.
Mourão PA, Pereira MS. Searching for Alternatives to Heparin: Sulfated Fucans From Marine Invertebrates. Trends Cardiovasc Med. 1999;9(8):225-32. PubMed PMID: 11094330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Searching for alternatives to heparin: sulfated fucans from marine invertebrates. AU - Mourão,P A, AU - Pereira,M S, PY - 2000/11/30/pubmed PY - 2001/2/28/medline PY - 2000/11/30/entrez SP - 225 EP - 32 JF - Trends in cardiovascular medicine JO - Trends Cardiovasc Med VL - 9 IS - 8 N2 - We describe a variety of sulfated polysaccharides with regular and well-defined structures which are useful tools for elucidating structure/biological function relationship. Several of these compounds have anticoagulant and antithrombotic activities. The most studied and promising polysaccharide is a fucosylated chondroitin sulfate, composed of a chondroitin sulfate-like backbone, substituted at position 3 of the beta-D-glucuronic acid with heavily sulfated fucose side chains. The anticoagulant activity of this polysaccharide is mediated by both antithrombin and heparin cofactor II; it has antithrombotic activity when targeted at the intrinsic coagulation pathway. SN - 1050-1738 UR - https://www.unboundmedicine.com/medline/citation/11094330/Searching_for_alternatives_to_heparin:_sulfated_fucans_from_marine_invertebrates_ DB - PRIME DP - Unbound Medicine ER -