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Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol).
Allerg Immunol (Paris). 2000 Sep; 32(7):272-8.AI

Abstract

A lipid-rich extract, prepared by supercritical fluid (CO2) extraction of freeze-dried stabilized NZ green-lipped mussel powder (Lyprinol) has shown significant anti-inflammatory (AI) activity when given to animals and humans. When treated p.o. with Lyprinol, Wistar and Dark Agouti rats developed neither adjuvant-induced polyarthritis or collagen(II)-induced auto-allergic arthritis. This was achieved with doses < NSAIDs, and 200 times < of other seed or fish oils. Lyprinol subfractions inhibited LTB4 biosynthesis by PMN in vitro, and PGE2 production by activated macrophages. Much of this AI activity was associated with omega-3 PUFAs and natural antioxidants [e.g. carotenoids]. In contrast to NSAIDs, Lyprinol is non-gastro toxic in disease-stressed rats at 300 mg/kg p.o., and does not affect platelet aggregation [human, rat]. Clinical studies, either controlled or randomized, have demonstrated very significant AI activity in patients with osteoarthritis (OA), rheumatoid arthritis (RA), asthma, and other inflammatory conditions. Lyprinol is a reproducible, stable source of bioactive lipids with much greater potency than plant/marine oils currently used as nutritional supplements to ameliorate signs of inflammation.

Authors+Show Affiliations

University of California, USA.

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

11094640

Citation

Halpern, G M.. "Anti-inflammatory Effects of a Stabilized Lipid Extract of Perna Canaliculus (Lyprinol)." Allergie Et Immunologie, vol. 32, no. 7, 2000, pp. 272-8.
Halpern GM. Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol). Allerg Immunol (Paris). 2000;32(7):272-8.
Halpern, G. M. (2000). Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol). Allergie Et Immunologie, 32(7), 272-8.
Halpern GM. Anti-inflammatory Effects of a Stabilized Lipid Extract of Perna Canaliculus (Lyprinol). Allerg Immunol (Paris). 2000;32(7):272-8. PubMed PMID: 11094640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol). A1 - Halpern,G M, PY - 2000/11/30/pubmed PY - 2001/2/28/medline PY - 2000/11/30/entrez SP - 272 EP - 8 JF - Allergie et immunologie JO - Allerg Immunol (Paris) VL - 32 IS - 7 N2 - A lipid-rich extract, prepared by supercritical fluid (CO2) extraction of freeze-dried stabilized NZ green-lipped mussel powder (Lyprinol) has shown significant anti-inflammatory (AI) activity when given to animals and humans. When treated p.o. with Lyprinol, Wistar and Dark Agouti rats developed neither adjuvant-induced polyarthritis or collagen(II)-induced auto-allergic arthritis. This was achieved with doses < NSAIDs, and 200 times < of other seed or fish oils. Lyprinol subfractions inhibited LTB4 biosynthesis by PMN in vitro, and PGE2 production by activated macrophages. Much of this AI activity was associated with omega-3 PUFAs and natural antioxidants [e.g. carotenoids]. In contrast to NSAIDs, Lyprinol is non-gastro toxic in disease-stressed rats at 300 mg/kg p.o., and does not affect platelet aggregation [human, rat]. Clinical studies, either controlled or randomized, have demonstrated very significant AI activity in patients with osteoarthritis (OA), rheumatoid arthritis (RA), asthma, and other inflammatory conditions. Lyprinol is a reproducible, stable source of bioactive lipids with much greater potency than plant/marine oils currently used as nutritional supplements to ameliorate signs of inflammation. SN - 0397-9148 UR - https://www.unboundmedicine.com/medline/citation/11094640/Anti_inflammatory_effects_of_a_stabilized_lipid_extract_of_Perna_canaliculus__Lyprinol__ L2 - https://www.lens.org/lens/search?q=citation_id:11094640 DB - PRIME DP - Unbound Medicine ER -