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Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C.
Am J Gastroenterol 2000; 95(11):3211-7AJ

Abstract

OBJECTIVE

The presence of steatosis is a common histological finding in patients with chronic hepatitis C (CHC). The causes of the severity of this condition are not yet clear, although both metabolic and viral factors supposedly are involved. In this study our aim was to examine the possible influence that leptin levels, hepatitis C virus (HCV) RNA levels, and hepatitis G virus (HGV) infection have on the severity of steatosis and on the presence and degree of fibrosis in patients with CHC.

METHODS

One hundred eighty-two CHC patients with histological findings of steatosis were chosen from among a cohort of patients referred to our center for staging of liver disease. Among them 48 CHC patients were accurately selected so as to rule out possible confounding factors for the presence of steatosis (diabetes mellitus, hyperlipemia, obesity, alcohol). Leptin levels, HCV RNA levels, and HCV genotype, and the presence of HGV RNA were assessed in these patients and related to histological findings.

RESULTS

We found that leptin levels in CHC patients were similar to those in healthy subjects. No relationship was found between leptin levels and severity of steatosis. HCV RNA levels, HCV genotype, and the presence of HGV infection were no different among CHC patients with various degrees of steatosis. Leptin was not related to different degrees of fibrosis, whereas higher viral load was the only parameter associated to higher fibrosis scores.

CONCLUSIONS

These findings suggest that the degree of steatosis in patients with CHC does not seem to depend on serum leptin levels or on viral factors, at least as far as HCV viremia and genotype and HGV infection are concerned. The severity of fibrosis does not seem to be influenced by leptin levels, whereas HCV viral load does seem to play some role.

Authors+Show Affiliations

Department of Internal Medicine, University of Genoa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11095344

Citation

Giannini, E, et al. "Leptin Has No Role in Determining Severity of Steatosis and Fibrosis in Patients With Chronic Hepatitis C." The American Journal of Gastroenterology, vol. 95, no. 11, 2000, pp. 3211-7.
Giannini E, Ceppa P, Botta F, et al. Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C. Am J Gastroenterol. 2000;95(11):3211-7.
Giannini, E., Ceppa, P., Botta, F., Mastracci, L., Romagnoli, P., Comino, I., ... Testa, R. (2000). Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C. The American Journal of Gastroenterology, 95(11), pp. 3211-7.
Giannini E, et al. Leptin Has No Role in Determining Severity of Steatosis and Fibrosis in Patients With Chronic Hepatitis C. Am J Gastroenterol. 2000;95(11):3211-7. PubMed PMID: 11095344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C. AU - Giannini,E, AU - Ceppa,P, AU - Botta,F, AU - Mastracci,L, AU - Romagnoli,P, AU - Comino,I, AU - Pasini,A, AU - Risso,D, AU - Lantieri,P B, AU - Icardi,G, AU - Barreca,T, AU - Testa,R, PY - 2000/11/30/pubmed PY - 2001/2/28/medline PY - 2000/11/30/entrez SP - 3211 EP - 7 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 95 IS - 11 N2 - OBJECTIVE: The presence of steatosis is a common histological finding in patients with chronic hepatitis C (CHC). The causes of the severity of this condition are not yet clear, although both metabolic and viral factors supposedly are involved. In this study our aim was to examine the possible influence that leptin levels, hepatitis C virus (HCV) RNA levels, and hepatitis G virus (HGV) infection have on the severity of steatosis and on the presence and degree of fibrosis in patients with CHC. METHODS: One hundred eighty-two CHC patients with histological findings of steatosis were chosen from among a cohort of patients referred to our center for staging of liver disease. Among them 48 CHC patients were accurately selected so as to rule out possible confounding factors for the presence of steatosis (diabetes mellitus, hyperlipemia, obesity, alcohol). Leptin levels, HCV RNA levels, and HCV genotype, and the presence of HGV RNA were assessed in these patients and related to histological findings. RESULTS: We found that leptin levels in CHC patients were similar to those in healthy subjects. No relationship was found between leptin levels and severity of steatosis. HCV RNA levels, HCV genotype, and the presence of HGV infection were no different among CHC patients with various degrees of steatosis. Leptin was not related to different degrees of fibrosis, whereas higher viral load was the only parameter associated to higher fibrosis scores. CONCLUSIONS: These findings suggest that the degree of steatosis in patients with CHC does not seem to depend on serum leptin levels or on viral factors, at least as far as HCV viremia and genotype and HGV infection are concerned. The severity of fibrosis does not seem to be influenced by leptin levels, whereas HCV viral load does seem to play some role. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/11095344/Leptin_has_no_role_in_determining_severity_of_steatosis_and_fibrosis_in_patients_with_chronic_hepatitis_C_ L2 - http://Insights.ovid.com/pubmed?pmid=11095344 DB - PRIME DP - Unbound Medicine ER -