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Aluminum forms in drinking water and risk of Alzheimer's disease.
Environ Res. 2000 Nov; 84(3):234-46.ER

Abstract

The objective of this study was to assess the relation between long-term exposure to different aluminum (Al) forms in drinking water and Alzheimer's disease (AD). The study participants were selected from a random sample of the elderly population (> or = 70 years of age) of the Saguenay-Lac-Saint-Jean region (Quebec). Sixty-eight cases of Alzheimer's disease diagnosed according to recognized criteria were paired for age (+/-2 years) and sex with nondemented controls. Aluminum speciation was assessed using established standard analytical protocols along with quality control procedures. Exposure to Al forms (total Al, total dissolved Al, monomeric organic Al, monomeric inorganic Al, polymeric Al, Al(3+), AlOH, AlF, AlH(3)SiO(2+)(4), AlSO(4)) in drinking water was estimated by juxtaposing the subject's residential history with the physicochemical data of the municipalities. The markers of long-term exposures (1945 to onset) to Al forms in drinking water were not significantly associated with AD. On the other hand, after adjustment for education level, presence of family cases, and ApoE varepsilon4 allele, exposure to organic monomeric aluminum estimated at the onset of the disease was associated with AD (odds ratio 2.67; 95% CI 1.04-6.90). On average, the exposure estimated at the onset had been stable for 44 years. Our results confirm prime the importance of estimation of Al speciation and consideration of genetic characteristics in the assessment of the association between aluminum exposure and Alzheimer's disease.

Authors+Show Affiliations

Département de Géographie, Université de Montréal, Montréal, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11097797

Citation

Gauthier, E, et al. "Aluminum Forms in Drinking Water and Risk of Alzheimer's Disease." Environmental Research, vol. 84, no. 3, 2000, pp. 234-46.
Gauthier E, Fortier I, Courchesne F, et al. Aluminum forms in drinking water and risk of Alzheimer's disease. Environ Res. 2000;84(3):234-46.
Gauthier, E., Fortier, I., Courchesne, F., Pepin, P., Mortimer, J., & Gauvreau, D. (2000). Aluminum forms in drinking water and risk of Alzheimer's disease. Environmental Research, 84(3), 234-46.
Gauthier E, et al. Aluminum Forms in Drinking Water and Risk of Alzheimer's Disease. Environ Res. 2000;84(3):234-46. PubMed PMID: 11097797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aluminum forms in drinking water and risk of Alzheimer's disease. AU - Gauthier,E, AU - Fortier,I, AU - Courchesne,F, AU - Pepin,P, AU - Mortimer,J, AU - Gauvreau,D, PY - 2000/12/1/pubmed PY - 2001/2/28/medline PY - 2000/12/1/entrez SP - 234 EP - 46 JF - Environmental research JO - Environ Res VL - 84 IS - 3 N2 - The objective of this study was to assess the relation between long-term exposure to different aluminum (Al) forms in drinking water and Alzheimer's disease (AD). The study participants were selected from a random sample of the elderly population (> or = 70 years of age) of the Saguenay-Lac-Saint-Jean region (Quebec). Sixty-eight cases of Alzheimer's disease diagnosed according to recognized criteria were paired for age (+/-2 years) and sex with nondemented controls. Aluminum speciation was assessed using established standard analytical protocols along with quality control procedures. Exposure to Al forms (total Al, total dissolved Al, monomeric organic Al, monomeric inorganic Al, polymeric Al, Al(3+), AlOH, AlF, AlH(3)SiO(2+)(4), AlSO(4)) in drinking water was estimated by juxtaposing the subject's residential history with the physicochemical data of the municipalities. The markers of long-term exposures (1945 to onset) to Al forms in drinking water were not significantly associated with AD. On the other hand, after adjustment for education level, presence of family cases, and ApoE varepsilon4 allele, exposure to organic monomeric aluminum estimated at the onset of the disease was associated with AD (odds ratio 2.67; 95% CI 1.04-6.90). On average, the exposure estimated at the onset had been stable for 44 years. Our results confirm prime the importance of estimation of Al speciation and consideration of genetic characteristics in the assessment of the association between aluminum exposure and Alzheimer's disease. SN - 0013-9351 UR - https://www.unboundmedicine.com/medline/citation/11097797/Aluminum_forms_in_drinking_water_and_risk_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(00)94101-X DB - PRIME DP - Unbound Medicine ER -