Tags

Type your tag names separated by a space and hit enter

Invasive fungal infections in pediatric bone marrow transplant recipients: single center experience of 10 years.
Bone Marrow Transplant. 2000 Nov; 26(9):999-1004.BM

Abstract

Invasive fungal infections (IFI) with substantial mortality constitute an increasing problem among BMT patients. From 1986 to 1996 148 children underwent BMT, and are included in a retrospective analysis of the incidence, risk factors and outcome of IFI. By histopathology or culture-proven IFI (Candida, 10; Aspergillus, 8) was documented in 12/73 (16%) allogeneic and in 6/75 (8%) autologous BMT patients. Of these 18 patients, 15 subsequently died, and in 12 (66%) IFI was regarded as the main cause of death. In addition to the patients with documented IFI, 48 had suspected and 82 no fungal infection. Invasive candidal infections were more frequent in patients with semiquantitatively estimated abundant candidal colonization as compared with those with no colonization (18% vs 3%, P = 0.015). In the allogeneic group, 50% of those with severe (grades III-IV) aGVHD had IFI as opposed to 8% of those with no or mild aGVHD (P < 0.001). Regarding cGVHD, 57% of those with extensive cGVHD vs 5% of those with absent or limited cGVHD had IFI (P < 0.001). The dose of steroids was associated with IFI: 77% of those who received high-dose steroids (methylprednisolone 0.25-1 g/day for 5 days) vs 5% of those with conventional-dose (prednisone 2 mg/kg/day) had IFI (P < 0.001). Particularly for BMT patients at risk, new, quicker and better diagnostic tests and more effective anti-fungal agents, both for prophylaxis and treatment, are needed.

Authors+Show Affiliations

Hospital for Children and Adolescents, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11100280

Citation

Hovi, L, et al. "Invasive Fungal Infections in Pediatric Bone Marrow Transplant Recipients: Single Center Experience of 10 Years." Bone Marrow Transplantation, vol. 26, no. 9, 2000, pp. 999-1004.
Hovi L, Saarinen-Pihkala UM, Vettenranta K, et al. Invasive fungal infections in pediatric bone marrow transplant recipients: single center experience of 10 years. Bone Marrow Transplant. 2000;26(9):999-1004.
Hovi, L., Saarinen-Pihkala, U. M., Vettenranta, K., & Saxen, H. (2000). Invasive fungal infections in pediatric bone marrow transplant recipients: single center experience of 10 years. Bone Marrow Transplantation, 26(9), 999-1004.
Hovi L, et al. Invasive Fungal Infections in Pediatric Bone Marrow Transplant Recipients: Single Center Experience of 10 Years. Bone Marrow Transplant. 2000;26(9):999-1004. PubMed PMID: 11100280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Invasive fungal infections in pediatric bone marrow transplant recipients: single center experience of 10 years. AU - Hovi,L, AU - Saarinen-Pihkala,U M, AU - Vettenranta,K, AU - Saxen,H, PY - 2000/12/2/pubmed PY - 2001/3/10/medline PY - 2000/12/2/entrez SP - 999 EP - 1004 JF - Bone marrow transplantation JO - Bone Marrow Transplant. VL - 26 IS - 9 N2 - Invasive fungal infections (IFI) with substantial mortality constitute an increasing problem among BMT patients. From 1986 to 1996 148 children underwent BMT, and are included in a retrospective analysis of the incidence, risk factors and outcome of IFI. By histopathology or culture-proven IFI (Candida, 10; Aspergillus, 8) was documented in 12/73 (16%) allogeneic and in 6/75 (8%) autologous BMT patients. Of these 18 patients, 15 subsequently died, and in 12 (66%) IFI was regarded as the main cause of death. In addition to the patients with documented IFI, 48 had suspected and 82 no fungal infection. Invasive candidal infections were more frequent in patients with semiquantitatively estimated abundant candidal colonization as compared with those with no colonization (18% vs 3%, P = 0.015). In the allogeneic group, 50% of those with severe (grades III-IV) aGVHD had IFI as opposed to 8% of those with no or mild aGVHD (P < 0.001). Regarding cGVHD, 57% of those with extensive cGVHD vs 5% of those with absent or limited cGVHD had IFI (P < 0.001). The dose of steroids was associated with IFI: 77% of those who received high-dose steroids (methylprednisolone 0.25-1 g/day for 5 days) vs 5% of those with conventional-dose (prednisone 2 mg/kg/day) had IFI (P < 0.001). Particularly for BMT patients at risk, new, quicker and better diagnostic tests and more effective anti-fungal agents, both for prophylaxis and treatment, are needed. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/11100280/Invasive_fungal_infections_in_pediatric_bone_marrow_transplant_recipients:_single_center_experience_of_10_years_ L2 - http://dx.doi.org/10.1038/sj.bmt.1702654 DB - PRIME DP - Unbound Medicine ER -