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Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults.

Abstract

BACKGROUND

Subclinical vitamin K insufficiency, manifested by under-gamma-carboxylation of the bone matrix protein osteocalcin, may be common.

OBJECTIVE

Our objective was to delineate the prevalence of submaximal gamma-carboxylation as assessed by response to phylloquinone supplementation and to evaluate the effect of this intervention on skeletal turnover in healthy North American adults.

DESIGN

Healthy subjects (n = 219), approximately equally distributed by sex and age (18-30 y and >/=65 y), received daily phylloquinone (1000 microg) or placebo for 2 wk. Serum undercarboxylated osteocalcin (ucOC) and total osteocalcin, N:-telopeptides of type I collagen (NTx), bone-specific alkaline phosphatase (BSAP), and phylloquinone concentrations were measured at baseline and after weeks 1 and 2.

RESULTS

At baseline, the mean serum phylloquinone concentration was lower in the young than in the old group; there was no effect of sex. Concomitantly, baseline %ucOC was highest in the young and lowest in the old men (P: < 0.0001) but did not differ significantly by age in women. After supplementation, serum phylloquinone concentration increased approximately 10-fold (P: < 0.0001) at week 1 (from 0.93 +/- 0.08 to 8.86 +/- 0.70 nmol/L, x+/- SEM); this was sustained through week 2. Among all supplemented groups, mean %ucOC decreased from 7.6% to 3. 4% without significant differences by age or sex; 102 of 112 subjects had a >1% decrease. Phylloquinone supplementation reduced serum osteocalcin but did not alter NTx or BSAP concentration.

CONCLUSIONS

Usual dietary practices in this population did not provide adequate vitamin K for maximal osteocalcin carboxylation. Phylloquinone supplementation reduced serum osteocalcin concentration but did not alter other markers of serum bone turnover.

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  • Authors+Show Affiliations

    ,

    Institute on Aging, Department of Medicine, University of Wisconsin, Madison, WI, USA. nbinkley@facstaff.wisc.edu

    , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aging
    Analysis of Variance
    Antifibrinolytic Agents
    Bone and Bones
    Dietary Supplements
    Female
    Humans
    Male
    Osteocalcin
    Single-Blind Method
    Vitamin K 1

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11101481

    Citation

    Binkley, N C., et al. "Vitamin K Supplementation Reduces Serum Concentrations of Under-gamma-carboxylated Osteocalcin in Healthy Young and Elderly Adults." The American Journal of Clinical Nutrition, vol. 72, no. 6, 2000, pp. 1523-8.
    Binkley NC, Krueger DC, Engelke JA, et al. Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults. Am J Clin Nutr. 2000;72(6):1523-8.
    Binkley, N. C., Krueger, D. C., Engelke, J. A., Foley, A. L., & Suttie, J. W. (2000). Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults. The American Journal of Clinical Nutrition, 72(6), pp. 1523-8.
    Binkley NC, et al. Vitamin K Supplementation Reduces Serum Concentrations of Under-gamma-carboxylated Osteocalcin in Healthy Young and Elderly Adults. Am J Clin Nutr. 2000;72(6):1523-8. PubMed PMID: 11101481.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults. AU - Binkley,N C, AU - Krueger,D C, AU - Engelke,J A, AU - Foley,A L, AU - Suttie,J W, PY - 2000/12/2/pubmed PY - 2001/2/28/medline PY - 2000/12/2/entrez SP - 1523 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 72 IS - 6 N2 - BACKGROUND: Subclinical vitamin K insufficiency, manifested by under-gamma-carboxylation of the bone matrix protein osteocalcin, may be common. OBJECTIVE: Our objective was to delineate the prevalence of submaximal gamma-carboxylation as assessed by response to phylloquinone supplementation and to evaluate the effect of this intervention on skeletal turnover in healthy North American adults. DESIGN: Healthy subjects (n = 219), approximately equally distributed by sex and age (18-30 y and >/=65 y), received daily phylloquinone (1000 microg) or placebo for 2 wk. Serum undercarboxylated osteocalcin (ucOC) and total osteocalcin, N:-telopeptides of type I collagen (NTx), bone-specific alkaline phosphatase (BSAP), and phylloquinone concentrations were measured at baseline and after weeks 1 and 2. RESULTS: At baseline, the mean serum phylloquinone concentration was lower in the young than in the old group; there was no effect of sex. Concomitantly, baseline %ucOC was highest in the young and lowest in the old men (P: < 0.0001) but did not differ significantly by age in women. After supplementation, serum phylloquinone concentration increased approximately 10-fold (P: < 0.0001) at week 1 (from 0.93 +/- 0.08 to 8.86 +/- 0.70 nmol/L, x+/- SEM); this was sustained through week 2. Among all supplemented groups, mean %ucOC decreased from 7.6% to 3. 4% without significant differences by age or sex; 102 of 112 subjects had a >1% decrease. Phylloquinone supplementation reduced serum osteocalcin but did not alter NTx or BSAP concentration. CONCLUSIONS: Usual dietary practices in this population did not provide adequate vitamin K for maximal osteocalcin carboxylation. Phylloquinone supplementation reduced serum osteocalcin concentration but did not alter other markers of serum bone turnover. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/11101481/Vitamin_K_supplementation_reduces_serum_concentrations_of_under_gamma_carboxylated_osteocalcin_in_healthy_young_and_elderly_adults_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/72.6.1523 DB - PRIME DP - Unbound Medicine ER -