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High constant incidence in twins and other relatives of women with breast cancer.

Abstract

The incidence of breast cancer rises steeply between ages 25 and 50, and more slowly thereafter. In contrast, the incidence in the unaffected (contralateral) breast of women who have had breast cancer remains constant at about 0.7% per year for at least the next 20 years after diagnosis, irrespective of age at first diagnosis. The incidence in relatives of the patients seems to show a similar pattern. The incidence in a prospective study of monozygotic twins of patients was approximately constant at 1.3% per year (77 cases), again about 0.7% per breast. At ages older than a patient's age at diagnosis, her mother and sisters have an incidence of 0.3-0.4% per year. Above the index patient's age at diagnosis, the rate in relatives shows no temporal trend and is independent of the patient's age at diagnosis. A statistically simple explanation is that incidence in susceptible women increases to a high constant level by a predetermined age that varies between families, but this seems inconsistent with conventional models of carcinogenesis and susceptibility. The very high incidence in monozygotic twins of patients indicates that a high proportion, and perhaps the majority, of breast cancers arise in a susceptible minority of women.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK. j.peto@icr.ac.uk

    Source

    Nature genetics 26:4 2000 Dec pg 411-4

    MeSH

    Adult
    Age Factors
    Aged
    Breast Neoplasms
    Diseases in Twins
    Environment
    Female
    Humans
    Middle Aged
    Mothers
    Neoplasms, Multiple Primary
    Nuclear Family
    Prospective Studies
    Risk Factors
    Twins, Monozygotic

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    11101836

    Citation

    Peto, J, and T M. Mack. "High Constant Incidence in Twins and Other Relatives of Women With Breast Cancer." Nature Genetics, vol. 26, no. 4, 2000, pp. 411-4.
    Peto J, Mack TM. High constant incidence in twins and other relatives of women with breast cancer. Nat Genet. 2000;26(4):411-4.
    Peto, J., & Mack, T. M. (2000). High constant incidence in twins and other relatives of women with breast cancer. Nature Genetics, 26(4), pp. 411-4.
    Peto J, Mack TM. High Constant Incidence in Twins and Other Relatives of Women With Breast Cancer. Nat Genet. 2000;26(4):411-4. PubMed PMID: 11101836.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High constant incidence in twins and other relatives of women with breast cancer. AU - Peto,J, AU - Mack,T M, PY - 2000/12/2/pubmed PY - 2001/2/28/medline PY - 2000/12/2/entrez SP - 411 EP - 4 JF - Nature genetics JO - Nat. Genet. VL - 26 IS - 4 N2 - The incidence of breast cancer rises steeply between ages 25 and 50, and more slowly thereafter. In contrast, the incidence in the unaffected (contralateral) breast of women who have had breast cancer remains constant at about 0.7% per year for at least the next 20 years after diagnosis, irrespective of age at first diagnosis. The incidence in relatives of the patients seems to show a similar pattern. The incidence in a prospective study of monozygotic twins of patients was approximately constant at 1.3% per year (77 cases), again about 0.7% per breast. At ages older than a patient's age at diagnosis, her mother and sisters have an incidence of 0.3-0.4% per year. Above the index patient's age at diagnosis, the rate in relatives shows no temporal trend and is independent of the patient's age at diagnosis. A statistically simple explanation is that incidence in susceptible women increases to a high constant level by a predetermined age that varies between families, but this seems inconsistent with conventional models of carcinogenesis and susceptibility. The very high incidence in monozygotic twins of patients indicates that a high proportion, and perhaps the majority, of breast cancers arise in a susceptible minority of women. SN - 1061-4036 UR - https://www.unboundmedicine.com/medline/citation/11101836/full_citation L2 - http://dx.doi.org/10.1038/82533 DB - PRIME DP - Unbound Medicine ER -