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Influence of the MexA-MexB-oprM multidrug efflux system on expression of the MexC-MexD-oprJ and MexE-MexF-oprN multidrug efflux systems in Pseudomonas aeruginosa.
J Antimicrob Chemother. 2000 Dec; 46(6):885-93.JA

Abstract

Of the Pseudomonas aeruginosa multidrug efflux systems, MexAB-OprM is expressed in wild-type cells, while MexCD-OprJ is not, and MexEF-OprN shows variable, strain-specific expression. In defined mutant strains, MexCD-OprJ expression increased with decreases in MexAB-OprM and was generally inversely related to MexAB-OprM expression. In so-called wild-type strains expressing MexEF-OprN, MexAB-OprM hyperexpression correlated with a decline in MexEF-OprN expression, while loss of MexAB-OprM was associated with increased expression of MexEF-OprN, also indicative of an inverse correlation between MexAB-OprM and MexEF-OprN expression. Still, the increases in MexCD-OprJ and MexEF-OprN failed to compensate for the loss of MexAB-OprM with respect to antibiotic resistance. Nonetheless, these data suggest that the overall complement of these MDR efflux systems is monitored and that alterations in the level of one efflux system may effect compensatory changes in the levels of the others.

Authors+Show Affiliations

Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11102405

Citation

Li, X Z., et al. "Influence of the MexA-MexB-oprM Multidrug Efflux System On Expression of the MexC-MexD-oprJ and MexE-MexF-oprN Multidrug Efflux Systems in Pseudomonas Aeruginosa." The Journal of Antimicrobial Chemotherapy, vol. 46, no. 6, 2000, pp. 885-93.
Li XZ, Barré N, Poole K. Influence of the MexA-MexB-oprM multidrug efflux system on expression of the MexC-MexD-oprJ and MexE-MexF-oprN multidrug efflux systems in Pseudomonas aeruginosa. J Antimicrob Chemother. 2000;46(6):885-93.
Li, X. Z., Barré, N., & Poole, K. (2000). Influence of the MexA-MexB-oprM multidrug efflux system on expression of the MexC-MexD-oprJ and MexE-MexF-oprN multidrug efflux systems in Pseudomonas aeruginosa. The Journal of Antimicrobial Chemotherapy, 46(6), 885-93.
Li XZ, Barré N, Poole K. Influence of the MexA-MexB-oprM Multidrug Efflux System On Expression of the MexC-MexD-oprJ and MexE-MexF-oprN Multidrug Efflux Systems in Pseudomonas Aeruginosa. J Antimicrob Chemother. 2000;46(6):885-93. PubMed PMID: 11102405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of the MexA-MexB-oprM multidrug efflux system on expression of the MexC-MexD-oprJ and MexE-MexF-oprN multidrug efflux systems in Pseudomonas aeruginosa. AU - Li,X Z, AU - Barré,N, AU - Poole,K, PY - 2000/12/5/pubmed PY - 2001/3/3/medline PY - 2000/12/5/entrez SP - 885 EP - 93 JF - The Journal of antimicrobial chemotherapy JO - J. Antimicrob. Chemother. VL - 46 IS - 6 N2 - Of the Pseudomonas aeruginosa multidrug efflux systems, MexAB-OprM is expressed in wild-type cells, while MexCD-OprJ is not, and MexEF-OprN shows variable, strain-specific expression. In defined mutant strains, MexCD-OprJ expression increased with decreases in MexAB-OprM and was generally inversely related to MexAB-OprM expression. In so-called wild-type strains expressing MexEF-OprN, MexAB-OprM hyperexpression correlated with a decline in MexEF-OprN expression, while loss of MexAB-OprM was associated with increased expression of MexEF-OprN, also indicative of an inverse correlation between MexAB-OprM and MexEF-OprN expression. Still, the increases in MexCD-OprJ and MexEF-OprN failed to compensate for the loss of MexAB-OprM with respect to antibiotic resistance. Nonetheless, these data suggest that the overall complement of these MDR efflux systems is monitored and that alterations in the level of one efflux system may effect compensatory changes in the levels of the others. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/11102405/Influence_of_the_MexA_MexB_oprM_multidrug_efflux_system_on_expression_of_the_MexC_MexD_oprJ_and_MexE_MexF_oprN_multidrug_efflux_systems_in_Pseudomonas_aeruginosa_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/46.6.885 DB - PRIME DP - Unbound Medicine ER -