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Simultaneous formation and detection of the reaction product of solid-state aspartame sweetener by FT-IR/DSC microscopic system.
Food Addit Contam. 2000 Oct; 17(10):821-7.FA

Abstract

The solid-state stability of aspartame hemihydrate (APM) sweetener during thermal treatment is important information for the food industry. The present study uses the novel technique of Fourier transform infrared microspectroscopy equipped with differential scanning calorimetry (FT-IR/DSC microscopic system) to accelerate and determine simultaneously the thermal-dependent impurity formation of solid-state APM. The results indicate a dramatic change in IR spectra from 50, 110 or 153 degrees C, which was respectively attributed to the onset temperature of water evaporation, dehydration and cyclization processes. It is suggested that the processes of dehydration and intramolecular cyclization occurred in the solid-state APM during the heating process. As an impurity, 3-carboxymethyl-6-benzyl-2,5-diketopiperazine (DKP) degraded from solid state APM via intramolecular cyclization and liberation of methanol. This was evidenced by this novel FT-IR/DSC microscopic system in a one-step procedure.

Authors+Show Affiliations

Lin SY
Biopharmaceutics Laboratory, Department of Medical Research & Education, Veterans General Hospital-Taipei, Shih-Pai, Taiwan, Republic of China. sylin@vghtpe.gov.tw
Cheng YD
No affiliation info available

MeSH

AspartameCalorimetry, Differential ScanningCyclizationDesiccationDrug StabilityPiperazinesSpectroscopy, Fourier Transform InfraredTemperature

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11103265

Citation

Lin, S Y., and Y D. Cheng. "Simultaneous Formation and Detection of the Reaction Product of Solid-state Aspartame Sweetener By FT-IR/DSC Microscopic System." Food Additives and Contaminants, vol. 17, no. 10, 2000, pp. 821-7.
Lin SY, Cheng YD. Simultaneous formation and detection of the reaction product of solid-state aspartame sweetener by FT-IR/DSC microscopic system. Food Addit Contam. 2000;17(10):821-7.
Lin, S. Y., & Cheng, Y. D. (2000). Simultaneous formation and detection of the reaction product of solid-state aspartame sweetener by FT-IR/DSC microscopic system. Food Additives and Contaminants, 17(10), 821-7.
Lin SY, Cheng YD. Simultaneous Formation and Detection of the Reaction Product of Solid-state Aspartame Sweetener By FT-IR/DSC Microscopic System. Food Addit Contam. 2000;17(10):821-7. PubMed PMID: 11103265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous formation and detection of the reaction product of solid-state aspartame sweetener by FT-IR/DSC microscopic system. AU - Lin,S Y, AU - Cheng,Y D, PY - 2000/12/5/pubmed PY - 2001/2/28/medline PY - 2000/12/5/entrez SP - 821 EP - 7 JF - Food additives and contaminants JO - Food Addit Contam VL - 17 IS - 10 N2 - The solid-state stability of aspartame hemihydrate (APM) sweetener during thermal treatment is important information for the food industry. The present study uses the novel technique of Fourier transform infrared microspectroscopy equipped with differential scanning calorimetry (FT-IR/DSC microscopic system) to accelerate and determine simultaneously the thermal-dependent impurity formation of solid-state APM. The results indicate a dramatic change in IR spectra from 50, 110 or 153 degrees C, which was respectively attributed to the onset temperature of water evaporation, dehydration and cyclization processes. It is suggested that the processes of dehydration and intramolecular cyclization occurred in the solid-state APM during the heating process. As an impurity, 3-carboxymethyl-6-benzyl-2,5-diketopiperazine (DKP) degraded from solid state APM via intramolecular cyclization and liberation of methanol. This was evidenced by this novel FT-IR/DSC microscopic system in a one-step procedure. SN - 0265-203X UR - https://www.unboundmedicine.com/medline/citation/11103265/Simultaneous_formation_and_detection_of_the_reaction_product_of_solid_state_aspartame_sweetener_by_FT_IR/DSC_microscopic_system_ DB - PRIME DP - Unbound Medicine ER -