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Effects of the cannabinoid ligand SR 141716A alone or in combination with delta9-tetrahydrocannabinol or scopolamine on learning in squirrel monkeys.
Behav Pharmacol. 2000 Aug; 11(5):377-86.BP

Abstract

To investigate the effects of the cannabinoids on learning and on scopolamine-induced disruptions in learning, delta9-tetrahydrocannabinol (delta9-THC), SR 141716A (an antagonist at CB1 receptors) and scopolamine were administered to squirrel monkeys responding in a repeated-acquisition task. In this task, monkeys acquired a different three-response sequence each session and responding was maintained by food presentation under a second-order fixed-ratio 5 schedule. When either delta9-THC (0.1-0.56 mg/kg, i.m.) or SR 141716A (1-10 mg/kg, i.m.) was administered alone, 60 and 75 min before the session, respectively, both cannabinoid ligands dose-dependently decreased the overall rate of responding and increased the overall percentage of errors. However, at a dose that had little or no effect alone (i.e. 1 mg/kg), SR 141716A antagonized the disruptive effects of delta9-THC (0.18-1.8 mg/kg) on acquisition, shifting the dose-effect curves for rate of responding and percentage of errors at least 1/2 log unit to the right. Finally, when either delta9-THC (0.001-1 mg/kg) or SR 141716A (0.32-10 mg/kg) was administered with scopolamine (0.01 or 0.032 mg/kg, 15 min before the session), greater rate-decreasing and error-increasing effects were obtained than with scopolamine alone. These results suggest that while low doses of SR 141716A can antagonize the effects of delta9-THC in squirrel monkeys, high doses can also disrupt acquisition when administered alone and potentiate the disruptive effects of scopolamine on acquisition.

Authors+Show Affiliations

Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, Brazil. esma@zaz.com.brNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11103889

Citation

Nakamura-Palacios, E M., et al. "Effects of the Cannabinoid Ligand SR 141716A Alone or in Combination With Delta9-tetrahydrocannabinol or Scopolamine On Learning in Squirrel Monkeys." Behavioural Pharmacology, vol. 11, no. 5, 2000, pp. 377-86.
Nakamura-Palacios EM, Winsauer PJ, Moerschbaecher JM. Effects of the cannabinoid ligand SR 141716A alone or in combination with delta9-tetrahydrocannabinol or scopolamine on learning in squirrel monkeys. Behav Pharmacol. 2000;11(5):377-86.
Nakamura-Palacios, E. M., Winsauer, P. J., & Moerschbaecher, J. M. (2000). Effects of the cannabinoid ligand SR 141716A alone or in combination with delta9-tetrahydrocannabinol or scopolamine on learning in squirrel monkeys. Behavioural Pharmacology, 11(5), 377-86.
Nakamura-Palacios EM, Winsauer PJ, Moerschbaecher JM. Effects of the Cannabinoid Ligand SR 141716A Alone or in Combination With Delta9-tetrahydrocannabinol or Scopolamine On Learning in Squirrel Monkeys. Behav Pharmacol. 2000;11(5):377-86. PubMed PMID: 11103889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the cannabinoid ligand SR 141716A alone or in combination with delta9-tetrahydrocannabinol or scopolamine on learning in squirrel monkeys. AU - Nakamura-Palacios,E M, AU - Winsauer,P J, AU - Moerschbaecher,J M, PY - 2000/12/5/pubmed PY - 2001/2/28/medline PY - 2000/12/5/entrez SP - 377 EP - 86 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 11 IS - 5 N2 - To investigate the effects of the cannabinoids on learning and on scopolamine-induced disruptions in learning, delta9-tetrahydrocannabinol (delta9-THC), SR 141716A (an antagonist at CB1 receptors) and scopolamine were administered to squirrel monkeys responding in a repeated-acquisition task. In this task, monkeys acquired a different three-response sequence each session and responding was maintained by food presentation under a second-order fixed-ratio 5 schedule. When either delta9-THC (0.1-0.56 mg/kg, i.m.) or SR 141716A (1-10 mg/kg, i.m.) was administered alone, 60 and 75 min before the session, respectively, both cannabinoid ligands dose-dependently decreased the overall rate of responding and increased the overall percentage of errors. However, at a dose that had little or no effect alone (i.e. 1 mg/kg), SR 141716A antagonized the disruptive effects of delta9-THC (0.18-1.8 mg/kg) on acquisition, shifting the dose-effect curves for rate of responding and percentage of errors at least 1/2 log unit to the right. Finally, when either delta9-THC (0.001-1 mg/kg) or SR 141716A (0.32-10 mg/kg) was administered with scopolamine (0.01 or 0.032 mg/kg, 15 min before the session), greater rate-decreasing and error-increasing effects were obtained than with scopolamine alone. These results suggest that while low doses of SR 141716A can antagonize the effects of delta9-THC in squirrel monkeys, high doses can also disrupt acquisition when administered alone and potentiate the disruptive effects of scopolamine on acquisition. SN - 0955-8810 UR - https://www.unboundmedicine.com/medline/citation/11103889/Effects_of_the_cannabinoid_ligand_SR_141716A_alone_or_in_combination_with_delta9_tetrahydrocannabinol_or_scopolamine_on_learning_in_squirrel_monkeys_ L2 - https://doi.org/10.1097/00008877-200008000-00003 DB - PRIME DP - Unbound Medicine ER -