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Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study.
Clin Nutr. 2000 Dec; 19(6):395-401.CN

Abstract

BACKGROUND & AIMS

Glutamine is recognized as a conditionally essential amino acid. Recent studies indicate that glutamine-containing total parenteral nutrition improves nitrogen economy, enhances gastrointestinal and immune functions and shortens hospital stay.

METHODS

Thirty-seven patients (19 w and 18 m; age 61. 4+/-10.4 years; BMI 23.7+/-2.8 kg/m(2)) following major abdominal surgery receiving an isonitrogenous isoenergetic TPN with or without alanyl-glutamine supplementation (0.5 g/kg BW/day), were evaluated in a double-blind, randomized, controlled trial over a five-day period by measuring nitrogen balance, selected biochemical parameters and length of hospital stay.

RESULTS

Supplemental alanyl-glutamine improved the overall mean (-3.5+/-1.6 vs. -5.5+/-1. 4 g N;P<0.05) and cumulative nitrogen balance (-14.1+/-9.1 vs. -21.7+/-11.4 g N;P<0.05) compared with the isonitrogenous, isoenergetic standard regimen. Alanyl-glutamine normalized plasma glutamine concentration and reduced the length of hospital stay (12.8+/-2.6 vs. 17.5+/-6.4 days;P<0.05).

CONCLUSIONS

The results of the study confirm that supplementation with synthetic alanyl-glutamine dipeptide is associated with cost containment due to shortened hospitalization and improved nitrogen economy.

Authors+Show Affiliations

Department of Anaesthesiology and Intensive Care Medicine, University of Münster, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11104589

Citation

Mertes, N, et al. "Cost Containment Through L-alanyl-L-glutamine Supplemented Total Parenteral Nutrition After Major Abdominal Surgery: a Prospective Randomized Double-blind Controlled Study." Clinical Nutrition (Edinburgh, Scotland), vol. 19, no. 6, 2000, pp. 395-401.
Mertes N, Schulzki C, Goeters C, et al. Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study. Clin Nutr. 2000;19(6):395-401.
Mertes, N., Schulzki, C., Goeters, C., Winde, G., Benzing, S., Kuhn, K. S., Van Aken, H., Stehle, P., & Fürst, P. (2000). Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study. Clinical Nutrition (Edinburgh, Scotland), 19(6), 395-401.
Mertes N, et al. Cost Containment Through L-alanyl-L-glutamine Supplemented Total Parenteral Nutrition After Major Abdominal Surgery: a Prospective Randomized Double-blind Controlled Study. Clin Nutr. 2000;19(6):395-401. PubMed PMID: 11104589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study. AU - Mertes,N, AU - Schulzki,C, AU - Goeters,C, AU - Winde,G, AU - Benzing,S, AU - Kuhn,K S, AU - Van Aken,H, AU - Stehle,P, AU - Fürst,P, PY - 2000/1/11/pubmed PY - 2001/9/28/medline PY - 2000/1/11/entrez SP - 395 EP - 401 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 19 IS - 6 N2 - BACKGROUND & AIMS: Glutamine is recognized as a conditionally essential amino acid. Recent studies indicate that glutamine-containing total parenteral nutrition improves nitrogen economy, enhances gastrointestinal and immune functions and shortens hospital stay. METHODS: Thirty-seven patients (19 w and 18 m; age 61. 4+/-10.4 years; BMI 23.7+/-2.8 kg/m(2)) following major abdominal surgery receiving an isonitrogenous isoenergetic TPN with or without alanyl-glutamine supplementation (0.5 g/kg BW/day), were evaluated in a double-blind, randomized, controlled trial over a five-day period by measuring nitrogen balance, selected biochemical parameters and length of hospital stay. RESULTS: Supplemental alanyl-glutamine improved the overall mean (-3.5+/-1.6 vs. -5.5+/-1. 4 g N;P<0.05) and cumulative nitrogen balance (-14.1+/-9.1 vs. -21.7+/-11.4 g N;P<0.05) compared with the isonitrogenous, isoenergetic standard regimen. Alanyl-glutamine normalized plasma glutamine concentration and reduced the length of hospital stay (12.8+/-2.6 vs. 17.5+/-6.4 days;P<0.05). CONCLUSIONS: The results of the study confirm that supplementation with synthetic alanyl-glutamine dipeptide is associated with cost containment due to shortened hospitalization and improved nitrogen economy. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/11104589/Cost_containment_through_L_alanyl_L_glutamine_supplemented_total_parenteral_nutrition_after_major_abdominal_surgery:_a_prospective_randomized_double_blind_controlled_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(00)90142-0 DB - PRIME DP - Unbound Medicine ER -