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Perioperative enteral nutrition and quality of life of severely malnourished head and neck cancer patients: a randomized clinical trial.
Clin Nutr. 2000 Dec; 19(6):437-44.CN

Abstract

BACKGROUND AND AIMS

This study evaluated the use of perioperative nutritional support on Quality of Life (QOL) in malnourished head and neck cancer patients undergoing surgery.

METHODS

49 Malnourished (weight loss >10%) head and neck cancer patients who were included in a nutrition intervention trial were randomized to receive either no preoperative and standard postoperative tube-feeding (group I), standard preoperative and postoperative tube-feeding (group II) or arginine-supplemented preoperative and postoperative tube-feeding (group III). Of these patients, 31 completed a full QOL assessment on the first day of preoperative nutritional support, one day before surgery, and 6 months after surgery. Both a disease-specific (EORTC QLQ-C30) and a generic questionnaire (COOP-WONCA) were used. One way analysis of variance (ANOVA) and the Kruskal-Wallis test were applied for testing differences in scores between groups.

RESULTS

Between baseline and the day before surgery, both preoperatively fed groups revealed a positive change for the dimensions physical and emotional functioning and dyspnea (with significance in group II, P=0.050,0.031,0.045 respectively). Group III showed a negative change in appetite (P=0.049). Between baseline and 6 months after surgery, there were no differences between group I and both pre-fed groups. There were no differences in favour of group III compared to group II.

CONCLUSION

Enteral nutrition improves QOL of severely malnourished head and neck cancer patients in the period preceding surgery. No benefit of preoperative enteral feeding on QOL could be demonstrated 6 months after surgery.

Authors+Show Affiliations

Dept of Dietetics, Nutrition Support Team, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11104595

Citation

Van Bokhorst-de Van der Schuer, M A., et al. "Perioperative Enteral Nutrition and Quality of Life of Severely Malnourished Head and Neck Cancer Patients: a Randomized Clinical Trial." Clinical Nutrition (Edinburgh, Scotland), vol. 19, no. 6, 2000, pp. 437-44.
Van Bokhorst-de Van der Schuer MA, Langendoen SI, Vondeling H, et al. Perioperative enteral nutrition and quality of life of severely malnourished head and neck cancer patients: a randomized clinical trial. Clin Nutr. 2000;19(6):437-44.
Van Bokhorst-de Van der Schuer, M. A., Langendoen, S. I., Vondeling, H., Kuik, D. J., Quak, J. J., & Van Leeuwen, P. A. (2000). Perioperative enteral nutrition and quality of life of severely malnourished head and neck cancer patients: a randomized clinical trial. Clinical Nutrition (Edinburgh, Scotland), 19(6), 437-44.
Van Bokhorst-de Van der Schuer MA, et al. Perioperative Enteral Nutrition and Quality of Life of Severely Malnourished Head and Neck Cancer Patients: a Randomized Clinical Trial. Clin Nutr. 2000;19(6):437-44. PubMed PMID: 11104595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perioperative enteral nutrition and quality of life of severely malnourished head and neck cancer patients: a randomized clinical trial. AU - Van Bokhorst-de Van der Schuer,M A, AU - Langendoen,S I, AU - Vondeling,H, AU - Kuik,D J, AU - Quak,J J, AU - Van Leeuwen,P A, PY - 2000/1/11/pubmed PY - 2001/9/28/medline PY - 2000/1/11/entrez SP - 437 EP - 44 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 19 IS - 6 N2 - BACKGROUND AND AIMS: This study evaluated the use of perioperative nutritional support on Quality of Life (QOL) in malnourished head and neck cancer patients undergoing surgery. METHODS: 49 Malnourished (weight loss >10%) head and neck cancer patients who were included in a nutrition intervention trial were randomized to receive either no preoperative and standard postoperative tube-feeding (group I), standard preoperative and postoperative tube-feeding (group II) or arginine-supplemented preoperative and postoperative tube-feeding (group III). Of these patients, 31 completed a full QOL assessment on the first day of preoperative nutritional support, one day before surgery, and 6 months after surgery. Both a disease-specific (EORTC QLQ-C30) and a generic questionnaire (COOP-WONCA) were used. One way analysis of variance (ANOVA) and the Kruskal-Wallis test were applied for testing differences in scores between groups. RESULTS: Between baseline and the day before surgery, both preoperatively fed groups revealed a positive change for the dimensions physical and emotional functioning and dyspnea (with significance in group II, P=0.050,0.031,0.045 respectively). Group III showed a negative change in appetite (P=0.049). Between baseline and 6 months after surgery, there were no differences between group I and both pre-fed groups. There were no differences in favour of group III compared to group II. CONCLUSION: Enteral nutrition improves QOL of severely malnourished head and neck cancer patients in the period preceding surgery. No benefit of preoperative enteral feeding on QOL could be demonstrated 6 months after surgery. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/11104595/Perioperative_enteral_nutrition_and_quality_of_life_of_severely_malnourished_head_and_neck_cancer_patients:_a_randomized_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261561400901481 DB - PRIME DP - Unbound Medicine ER -