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Porphyria cutanea tarda.
Australas J Dermatol. 2000 Nov; 41(4):197-206; quiz 207-8.AJ

Abstract

Porphyria cutanea tarda (PCT) is a metabolic disorder of haem biosynthesis caused by decreased activity of uroporphyrinogen decarboxylase. Porphyria cutanea tarda is manifest by fragility, erosions, bullae, milia and scars on sun-exposed skin. Excess porphyrins in the skin interact with light of approximately 400 nm-wavelength radiant energy, forming reactive oxygen species. Porphyria cutanea tarda is categorized as familial, acquired or toxic. Factors that may induce clinical expression of PCT in susceptible individuals include alcohol, oestrogen, iron, polyhalogenated compounds and viral infections. Porphyria cutanea tarda is associated with an increased incidence of the haemochromatosis gene. Treatments for PCT include withdrawal of aggravating factors, phlebotomy and oral antimalarial medications.

Authors+Show Affiliations

Department of Dermatology, Royal Melbourne Hospital, Victoria, Australia.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11105361

Citation

Bleasel, N R., and G A. Varigos. "Porphyria Cutanea Tarda." The Australasian Journal of Dermatology, vol. 41, no. 4, 2000, pp. 197-206; quiz 207-8.
Bleasel NR, Varigos GA. Porphyria cutanea tarda. Australas J Dermatol. 2000;41(4):197-206; quiz 207-8.
Bleasel, N. R., & Varigos, G. A. (2000). Porphyria cutanea tarda. The Australasian Journal of Dermatology, 41(4), 197-206; quiz 207-8.
Bleasel NR, Varigos GA. Porphyria Cutanea Tarda. Australas J Dermatol. 2000;41(4):197-206; quiz 207-8. PubMed PMID: 11105361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Porphyria cutanea tarda. AU - Bleasel,N R, AU - Varigos,G A, PY - 2000/12/6/pubmed PY - 2001/2/28/medline PY - 2000/12/6/entrez SP - 197-206; quiz 207-8 JF - The Australasian journal of dermatology JO - Australas. J. Dermatol. VL - 41 IS - 4 N2 - Porphyria cutanea tarda (PCT) is a metabolic disorder of haem biosynthesis caused by decreased activity of uroporphyrinogen decarboxylase. Porphyria cutanea tarda is manifest by fragility, erosions, bullae, milia and scars on sun-exposed skin. Excess porphyrins in the skin interact with light of approximately 400 nm-wavelength radiant energy, forming reactive oxygen species. Porphyria cutanea tarda is categorized as familial, acquired or toxic. Factors that may induce clinical expression of PCT in susceptible individuals include alcohol, oestrogen, iron, polyhalogenated compounds and viral infections. Porphyria cutanea tarda is associated with an increased incidence of the haemochromatosis gene. Treatments for PCT include withdrawal of aggravating factors, phlebotomy and oral antimalarial medications. SN - 0004-8380 UR - https://www.unboundmedicine.com/medline/citation/11105361/Porphyria_cutanea_tarda_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0004-8380&date=2000&volume=41&issue=4&spage=197 DB - PRIME DP - Unbound Medicine ER -