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Vascular endothelial growth factor in bacterial meningitis: detection in cerebrospinal fluid and localization in postmortem brain.
J Infect Dis. 2001 Jan 01; 183(1):149-53.JI

Abstract

Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of VEGF during bacterial meningitis, VEGF was measured in cerebrospinal fluid (CSF) and blood of 37 patients with bacterial meningitis and 51 control patients, including 16 patients with viral meningitis. Circulating VEGF levels were similar in bacterial meningitis patients and control patients. VEGF(CSF) was detected in 11 (30%) of 37 of bacterial meningitis patients (range, <25-633 pg/mL) but in none of the control patients. The median VEGF index was 6.2 (range, 0.6-42), indicating intrathecal production. Median CSF cell counts, protein levels, and CSF: serum albumin ratios were higher for patients with detectable VEGF(CSF), although the difference was not statistically significant. VEGF immunoreactivity in autopsy brain specimens was found in the inflammatory infiltrate of patients with bacterial meningitis. These results indicate that inflammatory cells secrete VEGF during bacterial meningitis and that VEGF may contribute to blood-brain barrier disruption.

Authors+Show Affiliations

Wilhelmina Children's Hospital, Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11106541

Citation

van der Flier, M, et al. "Vascular Endothelial Growth Factor in Bacterial Meningitis: Detection in Cerebrospinal Fluid and Localization in Postmortem Brain." The Journal of Infectious Diseases, vol. 183, no. 1, 2001, pp. 149-53.
van der Flier M, Stockhammer G, Vonk GJ, et al. Vascular endothelial growth factor in bacterial meningitis: detection in cerebrospinal fluid and localization in postmortem brain. J Infect Dis. 2001;183(1):149-53.
van der Flier, M., Stockhammer, G., Vonk, G. J., Nikkels, P. G., van Diemen-Steenvoorde, R. A., van der Vlist, G. J., Rupert, S. W., Schmutzhard, E., Gunsilius, E., Gastl, G., Hoepelman, A. I., Kimpen, J. L., & Geelen, S. P. (2001). Vascular endothelial growth factor in bacterial meningitis: detection in cerebrospinal fluid and localization in postmortem brain. The Journal of Infectious Diseases, 183(1), 149-53.
van der Flier M, et al. Vascular Endothelial Growth Factor in Bacterial Meningitis: Detection in Cerebrospinal Fluid and Localization in Postmortem Brain. J Infect Dis. 2001 Jan 1;183(1):149-53. PubMed PMID: 11106541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular endothelial growth factor in bacterial meningitis: detection in cerebrospinal fluid and localization in postmortem brain. AU - van der Flier,M, AU - Stockhammer,G, AU - Vonk,G J, AU - Nikkels,P G, AU - van Diemen-Steenvoorde,R A, AU - van der Vlist,G J, AU - Rupert,S W, AU - Schmutzhard,E, AU - Gunsilius,E, AU - Gastl,G, AU - Hoepelman,A I, AU - Kimpen,J L, AU - Geelen,S P, Y1 - 2000/11/30/ PY - 2000/05/11/received PY - 2000/09/28/revised PY - 2000/12/7/pubmed PY - 2001/3/3/medline PY - 2000/12/7/entrez SP - 149 EP - 53 JF - The Journal of infectious diseases JO - J Infect Dis VL - 183 IS - 1 N2 - Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of VEGF during bacterial meningitis, VEGF was measured in cerebrospinal fluid (CSF) and blood of 37 patients with bacterial meningitis and 51 control patients, including 16 patients with viral meningitis. Circulating VEGF levels were similar in bacterial meningitis patients and control patients. VEGF(CSF) was detected in 11 (30%) of 37 of bacterial meningitis patients (range, <25-633 pg/mL) but in none of the control patients. The median VEGF index was 6.2 (range, 0.6-42), indicating intrathecal production. Median CSF cell counts, protein levels, and CSF: serum albumin ratios were higher for patients with detectable VEGF(CSF), although the difference was not statistically significant. VEGF immunoreactivity in autopsy brain specimens was found in the inflammatory infiltrate of patients with bacterial meningitis. These results indicate that inflammatory cells secrete VEGF during bacterial meningitis and that VEGF may contribute to blood-brain barrier disruption. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/11106541/Vascular_endothelial_growth_factor_in_bacterial_meningitis:_detection_in_cerebrospinal_fluid_and_localization_in_postmortem_brain_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/317643 DB - PRIME DP - Unbound Medicine ER -