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Effects of DHEA replacement on bone mineral density and body composition in elderly women and men.
Clin Endocrinol (Oxf). 2000 Nov; 53(5):561-8.CE

Abstract

OBJECTIVE

Dehydroepiandrosterone (DHEA) is a precursor for both oestrogens and androgens. Its marked decline with ageing may influence age-related changes in tissues influenced by sex hormones. The aim of this study was to determine the effects of DHEA replacement on bone mineral density (BMD) and body composition in elderly women and men with low serum DHEA sulphate (DHEAS) levels.

DESIGN

Prospective 6 month trial of oral DHEA replacement, 50 mg/day.

PATIENTS

Experimental subjects were 10 women and eight men, aged 73 +/- 1 years. Control subjects were 10 women and eight men, aged 74 +/- 1 years.

MEASUREMENTS

BMD, body composition, serum markers of bone turnover, serum lipids and lipoproteins, oral glucose tolerance, serum IGF-I, total serum oestrogens and testosterone.

RESULTS

BMD of the total body and lumbar spine increased (mean +/- SEM; 1.6 +/- 0.6% and 2.5 +/- 0.8%, respectively; both P < or = 0.05), fat mass decreased (- 1.3 +/- 0.4 kg; P < 0.01) and fat-free mass increased (0.9 +/- 0.4 kg; P < or = 0. 05) in response to DHEA replacement. DHEA replacement also resulted in increases in serum IGF-I (from 108 +/- 8 to 143 +/- 7 microg/l; P < 0.01) and total serum testosterone concentrations (from 10.7 +/- 1.2 to 15.6 +/- 1.8 nmol/l in the men and from 2.1 +/- 0.2 to 4.5 +/- 0.4 nmol/l in the women; both P < or = 0.05).

CONCLUSIONS

The results provide preliminary evidence that DHEA replacement in those elderly women and men who have very low serum DHEAS levels can partially reverse age-related changes in fat mass, fat-free mass, and BMD, and raise the possibility that increases in IGF-I and/or testosterone play a role in mediating these effects of DHEA.

Authors+Show Affiliations

Washington University Claude Pepper Older Americans Independence Center, Division of Geriatrics and Gerontology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11106916

Citation

Villareal, D T., et al. "Effects of DHEA Replacement On Bone Mineral Density and Body Composition in Elderly Women and Men." Clinical Endocrinology, vol. 53, no. 5, 2000, pp. 561-8.
Villareal DT, Holloszy JO, Kohrt WM. Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin Endocrinol (Oxf). 2000;53(5):561-8.
Villareal, D. T., Holloszy, J. O., & Kohrt, W. M. (2000). Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clinical Endocrinology, 53(5), 561-8.
Villareal DT, Holloszy JO, Kohrt WM. Effects of DHEA Replacement On Bone Mineral Density and Body Composition in Elderly Women and Men. Clin Endocrinol (Oxf). 2000;53(5):561-8. PubMed PMID: 11106916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. AU - Villareal,D T, AU - Holloszy,J O, AU - Kohrt,W M, PY - 2000/12/7/pubmed PY - 2001/2/28/medline PY - 2000/12/7/entrez SP - 561 EP - 8 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 53 IS - 5 N2 - OBJECTIVE: Dehydroepiandrosterone (DHEA) is a precursor for both oestrogens and androgens. Its marked decline with ageing may influence age-related changes in tissues influenced by sex hormones. The aim of this study was to determine the effects of DHEA replacement on bone mineral density (BMD) and body composition in elderly women and men with low serum DHEA sulphate (DHEAS) levels. DESIGN: Prospective 6 month trial of oral DHEA replacement, 50 mg/day. PATIENTS: Experimental subjects were 10 women and eight men, aged 73 +/- 1 years. Control subjects were 10 women and eight men, aged 74 +/- 1 years. MEASUREMENTS: BMD, body composition, serum markers of bone turnover, serum lipids and lipoproteins, oral glucose tolerance, serum IGF-I, total serum oestrogens and testosterone. RESULTS: BMD of the total body and lumbar spine increased (mean +/- SEM; 1.6 +/- 0.6% and 2.5 +/- 0.8%, respectively; both P < or = 0.05), fat mass decreased (- 1.3 +/- 0.4 kg; P < 0.01) and fat-free mass increased (0.9 +/- 0.4 kg; P < or = 0. 05) in response to DHEA replacement. DHEA replacement also resulted in increases in serum IGF-I (from 108 +/- 8 to 143 +/- 7 microg/l; P < 0.01) and total serum testosterone concentrations (from 10.7 +/- 1.2 to 15.6 +/- 1.8 nmol/l in the men and from 2.1 +/- 0.2 to 4.5 +/- 0.4 nmol/l in the women; both P < or = 0.05). CONCLUSIONS: The results provide preliminary evidence that DHEA replacement in those elderly women and men who have very low serum DHEAS levels can partially reverse age-related changes in fat mass, fat-free mass, and BMD, and raise the possibility that increases in IGF-I and/or testosterone play a role in mediating these effects of DHEA. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/11106916/Effects_of_DHEA_replacement_on_bone_mineral_density_and_body_composition_in_elderly_women_and_men_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0300-0664&amp;date=2000&amp;volume=53&amp;issue=5&amp;spage=561 DB - PRIME DP - Unbound Medicine ER -