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[Influence of gluten free diet on bone mineral density (BMD) in children with celiac disease].
Przegl Lek. 2000; 57(6):330-3.PL

Abstract

In children with celiac disease (CD) bone metabolism and mineralization are frequently disturbed. The present study aimed to assess the influence of gluten free diet (GFD) on bone mineral density (BMD) in 73 children with CD, mean age of 12.4 +/- 0.4 years and mean body mass index (BMI) 17.9 +/- 0.4 kg/m2 (mean +/- SEM). Diagnosis of CD was established according to ESPEGAN criteria. Compliance to the GFD was verified on the basis of interview and by estimation of antiendomysial antibodies (IgAEmA/IgGEmA) in blood serum. BMD was measured by dual energy X-ray absorptiometry (DEXA). Plasma calcium (Ca) and phosphorus (P) concentrations, alkaline phosphatase (AP) and its bone fraction (BAP) were estimated before BMD measurement. All children were divided into two groups. Group A consisted of 33 children where gluten free diet was strictly respected for 11.7 +/- 0.6 years. The second group (Group B) comprised 40 children without strictly respected GFD. Children who strictly followed GFD showed statistically higher BMI, AP-spine BMD and total body BMD in comparison with children without GFD (BMI 19 +/- 0.52 kg/m2 vs 17.3 +/- 0.4 kg/m2; p < 0.01, AP-spine BMD 0.951 +/- 0.04 g/cm2 vs 0.767 + 0.03 g/cm2; p < 0.005, Total Body BMD 1.013 +/- 0.02 g/cm2 vs 0.933 +/- 0.01 g/cm2; p < 0.05) respectively. No significant differences were found in plasma Ca, P, AP, BAP between both groups. A statistically significant positive correlation (p < 0.001) was found between duration of GFD and AP-spine BMD and total body BMD, respectively. A statistically significant positive correlation (p < 0.05) was also found between duration of GFD and BMI.

CONCLUSION

Long-term GFD significantly improves BMD and BMI in children with CD.

Authors+Show Affiliations

Katedra i Klinika Nefrologii, Endokrynologii i Chorób Przemiany Materii, Slaska Akademia Medyczna, Katowice.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article

Language

pol

PubMed ID

11107867

Citation

Karkoszka, H, et al. "[Influence of Gluten Free Diet On Bone Mineral Density (BMD) in Children With Celiac Disease]." Przeglad Lekarski, vol. 57, no. 6, 2000, pp. 330-3.
Karkoszka H, Kalita B, Wiecek A, et al. [Influence of gluten free diet on bone mineral density (BMD) in children with celiac disease]. Prz Lek. 2000;57(6):330-3.
Karkoszka, H., Kalita, B., Wiecek, A., Slimok, M., Sikora, A., Kokot, F., & Szczepanski, Z. (2000). [Influence of gluten free diet on bone mineral density (BMD) in children with celiac disease]. Przeglad Lekarski, 57(6), 330-3.
Karkoszka H, et al. [Influence of Gluten Free Diet On Bone Mineral Density (BMD) in Children With Celiac Disease]. Prz Lek. 2000;57(6):330-3. PubMed PMID: 11107867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influence of gluten free diet on bone mineral density (BMD) in children with celiac disease]. AU - Karkoszka,H, AU - Kalita,B, AU - Wiecek,A, AU - Slimok,M, AU - Sikora,A, AU - Kokot,F, AU - Szczepanski,Z, PY - 2000/12/7/pubmed PY - 2001/2/28/medline PY - 2000/12/7/entrez SP - 330 EP - 3 JF - Przeglad lekarski JO - Prz. Lek. VL - 57 IS - 6 N2 - UNLABELLED: In children with celiac disease (CD) bone metabolism and mineralization are frequently disturbed. The present study aimed to assess the influence of gluten free diet (GFD) on bone mineral density (BMD) in 73 children with CD, mean age of 12.4 +/- 0.4 years and mean body mass index (BMI) 17.9 +/- 0.4 kg/m2 (mean +/- SEM). Diagnosis of CD was established according to ESPEGAN criteria. Compliance to the GFD was verified on the basis of interview and by estimation of antiendomysial antibodies (IgAEmA/IgGEmA) in blood serum. BMD was measured by dual energy X-ray absorptiometry (DEXA). Plasma calcium (Ca) and phosphorus (P) concentrations, alkaline phosphatase (AP) and its bone fraction (BAP) were estimated before BMD measurement. All children were divided into two groups. Group A consisted of 33 children where gluten free diet was strictly respected for 11.7 +/- 0.6 years. The second group (Group B) comprised 40 children without strictly respected GFD. Children who strictly followed GFD showed statistically higher BMI, AP-spine BMD and total body BMD in comparison with children without GFD (BMI 19 +/- 0.52 kg/m2 vs 17.3 +/- 0.4 kg/m2; p < 0.01, AP-spine BMD 0.951 +/- 0.04 g/cm2 vs 0.767 + 0.03 g/cm2; p < 0.005, Total Body BMD 1.013 +/- 0.02 g/cm2 vs 0.933 +/- 0.01 g/cm2; p < 0.05) respectively. No significant differences were found in plasma Ca, P, AP, BAP between both groups. A statistically significant positive correlation (p < 0.001) was found between duration of GFD and AP-spine BMD and total body BMD, respectively. A statistically significant positive correlation (p < 0.05) was also found between duration of GFD and BMI. CONCLUSION: Long-term GFD significantly improves BMD and BMI in children with CD. SN - 0033-2240 UR - https://www.unboundmedicine.com/medline/citation/11107867/[Influence_of_gluten_free_diet_on_bone_mineral_density__BMD__in_children_with_celiac_disease]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -