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[The effects of enalapril on exercise capacity and right ventricular function in patients with chronic cor pulmonale].
An Med Interna. 2000 Oct; 17(10):527-32.AM

Abstract

BACKGROUND

Chronic cor pulmonale (CPC) in patients with chronic obstructive pulmonary disease (COPD) is a predictor of mortality. ACE inhibitors (ACEIs) improve the symptoms and reduce mortality of left ventricular or congestive failure, however their long term use in patients with CPC has not been tested. The aim of this study is to assess the effect on exercise tolerance and cardiorespiratory function of long term administration of enalapril in patients with CPC.

METHODS

Placebo-controlled, double blind, randomized study. 28 patients (24 men and 4 women, mean age of 68.11 +/- 7.78, range 51-79) with CPC and without exacerbation of their respiratory symptoms at baseline were double blind randomised to receive enalapril or placebo for 6 months, added to their previous therapy. Respiratory function test, exercise tolerance ("six minutes walking test") and isotopic ventriculography were performed at baseline and at the end of the study.

RESULTS

At baseline there were no differences in FEV1, FVC, FEV1/FVC and exercise tolerance. Both placebo and enalapril were well tolerated. At the end of the study, patients taking enalapril increased their exercise tolerance an 8.9% (19 m) vs 4.7% (33 m) in the placebo group (p 0.44; 95 percent confidence interval, -41.10 to 91.99). RVEF improved a 6.4% with enalapril but worsened a 7.09% in placebo group (p 0.15; 95 percent confidence interval, -12.87 to 2.10).

CONCLUSIONS

Long term administration of enalapril do not improve neither exercise tolerance, nor right ventricular (RV) function, although given in increasingly doses is well tolerated and might prevent further worsening in RV systolic function.

Authors+Show Affiliations

Servicio de Medicina Interna B, Hospital Clínico Universitario, Zaragoza. jiperez@posta.unizar.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

11109647

Citation

Pérez-Calvo, J, et al. "[The Effects of Enalapril On Exercise Capacity and Right Ventricular Function in Patients With Chronic Cor Pulmonale]." Anales De Medicina Interna (Madrid, Spain : 1984), vol. 17, no. 10, 2000, pp. 527-32.
Pérez-Calvo J, Civeira F, Ferrando J, et al. [The effects of enalapril on exercise capacity and right ventricular function in patients with chronic cor pulmonale]. An Med Interna. 2000;17(10):527-32.
Pérez-Calvo, J., Civeira, F., Ferrando, J., Martínez-Rodés, P., Torralba, M. A., Banzo, J., Prats, E., & Bueno, J. (2000). [The effects of enalapril on exercise capacity and right ventricular function in patients with chronic cor pulmonale]. Anales De Medicina Interna (Madrid, Spain : 1984), 17(10), 527-32.
Pérez-Calvo J, et al. [The Effects of Enalapril On Exercise Capacity and Right Ventricular Function in Patients With Chronic Cor Pulmonale]. An Med Interna. 2000;17(10):527-32. PubMed PMID: 11109647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effects of enalapril on exercise capacity and right ventricular function in patients with chronic cor pulmonale]. AU - Pérez-Calvo,J, AU - Civeira,F, AU - Ferrando,J, AU - Martínez-Rodés,P, AU - Torralba,M A, AU - Banzo,J, AU - Prats,E, AU - Bueno,J, PY - 2000/12/8/pubmed PY - 2001/2/28/medline PY - 2000/12/8/entrez SP - 527 EP - 32 JF - Anales de medicina interna (Madrid, Spain : 1984) JO - An Med Interna VL - 17 IS - 10 N2 - BACKGROUND: Chronic cor pulmonale (CPC) in patients with chronic obstructive pulmonary disease (COPD) is a predictor of mortality. ACE inhibitors (ACEIs) improve the symptoms and reduce mortality of left ventricular or congestive failure, however their long term use in patients with CPC has not been tested. The aim of this study is to assess the effect on exercise tolerance and cardiorespiratory function of long term administration of enalapril in patients with CPC. METHODS: Placebo-controlled, double blind, randomized study. 28 patients (24 men and 4 women, mean age of 68.11 +/- 7.78, range 51-79) with CPC and without exacerbation of their respiratory symptoms at baseline were double blind randomised to receive enalapril or placebo for 6 months, added to their previous therapy. Respiratory function test, exercise tolerance ("six minutes walking test") and isotopic ventriculography were performed at baseline and at the end of the study. RESULTS: At baseline there were no differences in FEV1, FVC, FEV1/FVC and exercise tolerance. Both placebo and enalapril were well tolerated. At the end of the study, patients taking enalapril increased their exercise tolerance an 8.9% (19 m) vs 4.7% (33 m) in the placebo group (p 0.44; 95 percent confidence interval, -41.10 to 91.99). RVEF improved a 6.4% with enalapril but worsened a 7.09% in placebo group (p 0.15; 95 percent confidence interval, -12.87 to 2.10). CONCLUSIONS: Long term administration of enalapril do not improve neither exercise tolerance, nor right ventricular (RV) function, although given in increasingly doses is well tolerated and might prevent further worsening in RV systolic function. SN - 0212-7199 UR - https://www.unboundmedicine.com/medline/citation/11109647/[The_effects_of_enalapril_on_exercise_capacity_and_right_ventricular_function_in_patients_with_chronic_cor_pulmonale]_ DB - PRIME DP - Unbound Medicine ER -