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Screening of amphetamine/methamphetamine and their derivatives in urine using FPIA and Triage 8 and the Scope and limits of a subsequent identification by means of the REMEDi HS system.
J Forensic Sci. 2000 Nov; 45(6):1327-31.JF

Abstract

This study describes screening and identifying amphetamines, methamphetamines, and their derivatives in urine using immunochemical (Triage, FPIA) and chromatographic techniques (REMEDi HS). Amphetamines, methamphetamines, MDMA (3,4-methylenedioxymethamphetamine), MDA (3,4-methylenedioxyamphetamine), MDE (3,4-methylenedioxyethyl-amphetainine), MBDB (N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine), BDB (3,4-(methylenedioxyphenyl)-2-butanamine), PMA (4-methoxyamphetamine), DOM (2,5-dimethyloxy-4-methylamphetamine), DOB (4-bromo-2,5-dimethyloxyamphetamine), amphetaminil, pholedrine, fenfluramine, and amfepramone were subjected to a comparative study. For this, the substances were analyzed to determine their specific threshold concentration for a positive detection in the Triage test and their limit of detection and positive threshold concentration for the FPIA test and the results compared. Furthermore, the capabilities of a more detailed analysis with the REMEDi system were studied. This HPLC system was able to produce information on the single drugs and main metabolites found in the sample with the danger of false-positive or false-negative screening results greatly minimized.

Authors+Show Affiliations

Faculty of Medicine, Carl Gustav Carus of the Technical University of Dresden Institute of Forensic Medicine, Germany.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11110193

Citation

Felscher, D, and K Schulz. "Screening of Amphetamine/methamphetamine and Their Derivatives in Urine Using FPIA and Triage 8 and the Scope and Limits of a Subsequent Identification By Means of the REMEDi HS System." Journal of Forensic Sciences, vol. 45, no. 6, 2000, pp. 1327-31.
Felscher D, Schulz K. Screening of amphetamine/methamphetamine and their derivatives in urine using FPIA and Triage 8 and the Scope and limits of a subsequent identification by means of the REMEDi HS system. J Forensic Sci. 2000;45(6):1327-31.
Felscher, D., & Schulz, K. (2000). Screening of amphetamine/methamphetamine and their derivatives in urine using FPIA and Triage 8 and the Scope and limits of a subsequent identification by means of the REMEDi HS system. Journal of Forensic Sciences, 45(6), 1327-31.
Felscher D, Schulz K. Screening of Amphetamine/methamphetamine and Their Derivatives in Urine Using FPIA and Triage 8 and the Scope and Limits of a Subsequent Identification By Means of the REMEDi HS System. J Forensic Sci. 2000;45(6):1327-31. PubMed PMID: 11110193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening of amphetamine/methamphetamine and their derivatives in urine using FPIA and Triage 8 and the Scope and limits of a subsequent identification by means of the REMEDi HS system. AU - Felscher,D, AU - Schulz,K, PY - 2000/12/8/pubmed PY - 2001/2/28/medline PY - 2000/12/8/entrez SP - 1327 EP - 31 JF - Journal of forensic sciences JO - J Forensic Sci VL - 45 IS - 6 N2 - This study describes screening and identifying amphetamines, methamphetamines, and their derivatives in urine using immunochemical (Triage, FPIA) and chromatographic techniques (REMEDi HS). Amphetamines, methamphetamines, MDMA (3,4-methylenedioxymethamphetamine), MDA (3,4-methylenedioxyamphetamine), MDE (3,4-methylenedioxyethyl-amphetainine), MBDB (N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine), BDB (3,4-(methylenedioxyphenyl)-2-butanamine), PMA (4-methoxyamphetamine), DOM (2,5-dimethyloxy-4-methylamphetamine), DOB (4-bromo-2,5-dimethyloxyamphetamine), amphetaminil, pholedrine, fenfluramine, and amfepramone were subjected to a comparative study. For this, the substances were analyzed to determine their specific threshold concentration for a positive detection in the Triage test and their limit of detection and positive threshold concentration for the FPIA test and the results compared. Furthermore, the capabilities of a more detailed analysis with the REMEDi system were studied. This HPLC system was able to produce information on the single drugs and main metabolites found in the sample with the danger of false-positive or false-negative screening results greatly minimized. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/11110193/Screening_of_amphetamine/methamphetamine_and_their_derivatives_in_urine_using_FPIA_and_Triage_8_and_the_Scope_and_limits_of_a_subsequent_identification_by_means_of_the_REMEDi_HS_system_ L2 - https://medlineplus.gov/methamphetamine.html DB - PRIME DP - Unbound Medicine ER -