Tags

Type your tag names separated by a space and hit enter

Immunization against influenza: comparison of various topical and parenteral regimens containing inactivated and/or live attenuated vaccines in healthy adults.
J Infect Dis. 2001 Jan 15; 183(2):329-332.JI

Abstract

Methods for enhancing immune responses to influenza were explored in 2 double-blind, placebo-controlled trials. Intranasal (inl) immunization with monovalent, live attenuated, cold-adapted recombinant (CR) or inactivated influenza virus (MIV) vaccine and intramuscular (im) immunization with MIV were evaluated in various combinations. Healthy susceptible adults were assigned randomly to receive 10(7.1) TCID(50) of CR (A/H1N1 or A/H3N2), homologous MIV (15 microg), or placebo inl and placebo or homologous MIV im (6 groups in each study). Serum antibody responses were greatest in groups given im vaccine (with or without inl vaccine). A 2-fold increase in nasal wash antibody response frequencies was seen in groups given combined inl (CR or MIV) and im vaccine, compared with subjects given a single im (MIV) or inl (CR or MIV) vaccine. Combined inl and im immunization is a promising approach for enhancing both local and systemic immune responses against influenza.

Authors+Show Affiliations

Keitel WA
Departments of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. wkeitel@bcm.tmc.edu
Cate TR
No affiliation info available
Nino D
No affiliation info available
Huggins LL
No affiliation info available
Six HR
No affiliation info available
Quarles JM
No affiliation info available
Couch RB
No affiliation info available

MeSH

Administration, IntranasalAdolescentAdultAntibodies, ViralCold TemperatureDouble-Blind MethodHumansInfluenza A virusInfluenza VaccinesInfluenza, HumanInjections, IntramuscularVaccinationVaccines, AttenuatedVaccines, InactivatedVaccines, Synthetic

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11110645

Citation

Keitel, W A., et al. "Immunization Against Influenza: Comparison of Various Topical and Parenteral Regimens Containing Inactivated And/or Live Attenuated Vaccines in Healthy Adults." The Journal of Infectious Diseases, vol. 183, no. 2, 2001, pp. 329-332.
Keitel WA, Cate TR, Nino D, et al. Immunization against influenza: comparison of various topical and parenteral regimens containing inactivated and/or live attenuated vaccines in healthy adults. J Infect Dis. 2001;183(2):329-332.
Keitel, W. A., Cate, T. R., Nino, D., Huggins, L. L., Six, H. R., Quarles, J. M., & Couch, R. B. (2001). Immunization against influenza: comparison of various topical and parenteral regimens containing inactivated and/or live attenuated vaccines in healthy adults. The Journal of Infectious Diseases, 183(2), 329-332.
Keitel WA, et al. Immunization Against Influenza: Comparison of Various Topical and Parenteral Regimens Containing Inactivated And/or Live Attenuated Vaccines in Healthy Adults. J Infect Dis. 2001 Jan 15;183(2):329-332. PubMed PMID: 11110645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunization against influenza: comparison of various topical and parenteral regimens containing inactivated and/or live attenuated vaccines in healthy adults. AU - Keitel,W A, AU - Cate,T R, AU - Nino,D, AU - Huggins,L L, AU - Six,H R, AU - Quarles,J M, AU - Couch,R B, Y1 - 2000/12/08/ PY - 2000/07/07/received PY - 2000/09/25/revised PY - 2000/12/9/pubmed PY - 2001/3/3/medline PY - 2000/12/9/entrez SP - 329 EP - 332 JF - The Journal of infectious diseases JO - J Infect Dis VL - 183 IS - 2 N2 - Methods for enhancing immune responses to influenza were explored in 2 double-blind, placebo-controlled trials. Intranasal (inl) immunization with monovalent, live attenuated, cold-adapted recombinant (CR) or inactivated influenza virus (MIV) vaccine and intramuscular (im) immunization with MIV were evaluated in various combinations. Healthy susceptible adults were assigned randomly to receive 10(7.1) TCID(50) of CR (A/H1N1 or A/H3N2), homologous MIV (15 microg), or placebo inl and placebo or homologous MIV im (6 groups in each study). Serum antibody responses were greatest in groups given im vaccine (with or without inl vaccine). A 2-fold increase in nasal wash antibody response frequencies was seen in groups given combined inl (CR or MIV) and im vaccine, compared with subjects given a single im (MIV) or inl (CR or MIV) vaccine. Combined inl and im immunization is a promising approach for enhancing both local and systemic immune responses against influenza. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/11110645/Immunization_against_influenza:_comparison_of_various_topical_and_parenteral_regimens_containing_inactivated_and/or_live_attenuated_vaccines_in_healthy_adults_ DB - PRIME DP - Unbound Medicine ER -