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Immunologic dynamics in hemophiliac patients infected with hepatitis C virus and human immunodeficiency virus: influence of antiretroviral therapy.
Blood 2000; 96(13):4293-9Blood

Abstract

Infection with hepatitis C virus (HCV) or human immunodeficiency virus (HIV) or both is common in hemophiliac patients due to putative transmission through clotting factor concentrates. Recently, highly active antiretroviral therapy (HAART) has been found to markedly improve viremia and immunologic parameters in patients infected with HIV. This report considers interactions between these viral infections, the immune system, and antiretroviral therapy. A total of 130 male hemophiliac patients were grouped according to type of viremia (HCV, HIV, both, or neither). Along with 30 healthy men age-matched to viremic patients, these groups were compared with respect to viral load and immunologic parameters. Thirty-five patients treated as above for HIV were serially followed up. HCV infection was associated with reduced peripheral B-cell and CD4(+)-cell counts and with increased serum IgG and IgM levels, whereas HIV infection was associated with reduced peripheral CD4(+)-cell counts and increased serum IgG and IgA levels. In patients with both viruses, HCV and HIV RNA load correlated inversely with peripheral B-cell and CD4(+)-cell counts, respectively. HAART reduced levels of both viruses in the blood. Of the 25 patients with both viruses, HAART eliminated HCV in 2. In conclusion, immunologic dynamics differed between hemophiliac patients infected with HCV, HIV, or both. The relative dynamics of HCV viral load, peripheral B-cell count, and serum IgM level were similar to those of HIV viral load, CD4(+)-cell count, and serum IgA. (Blood. 2000;96:4293-4299)

Authors+Show Affiliations

Second Department of Internal Medicine, Nagoya University, School of Medicine, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11110704

Citation

Yokozaki, S, et al. "Immunologic Dynamics in Hemophiliac Patients Infected With Hepatitis C Virus and Human Immunodeficiency Virus: Influence of Antiretroviral Therapy." Blood, vol. 96, no. 13, 2000, pp. 4293-9.
Yokozaki S, Takamatsu J, Nakano I, et al. Immunologic dynamics in hemophiliac patients infected with hepatitis C virus and human immunodeficiency virus: influence of antiretroviral therapy. Blood. 2000;96(13):4293-9.
Yokozaki, S., Takamatsu, J., Nakano, I., Katano, Y., Toyoda, H., Hayashi, K., ... Fukuda, Y. (2000). Immunologic dynamics in hemophiliac patients infected with hepatitis C virus and human immunodeficiency virus: influence of antiretroviral therapy. Blood, 96(13), pp. 4293-9.
Yokozaki S, et al. Immunologic Dynamics in Hemophiliac Patients Infected With Hepatitis C Virus and Human Immunodeficiency Virus: Influence of Antiretroviral Therapy. Blood. 2000 Dec 15;96(13):4293-9. PubMed PMID: 11110704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunologic dynamics in hemophiliac patients infected with hepatitis C virus and human immunodeficiency virus: influence of antiretroviral therapy. AU - Yokozaki,S, AU - Takamatsu,J, AU - Nakano,I, AU - Katano,Y, AU - Toyoda,H, AU - Hayashi,K, AU - Hayakawa,T, AU - Fukuda,Y, PY - 2000/12/9/pubmed PY - 2001/2/28/medline PY - 2000/12/9/entrez SP - 4293 EP - 9 JF - Blood JO - Blood VL - 96 IS - 13 N2 - Infection with hepatitis C virus (HCV) or human immunodeficiency virus (HIV) or both is common in hemophiliac patients due to putative transmission through clotting factor concentrates. Recently, highly active antiretroviral therapy (HAART) has been found to markedly improve viremia and immunologic parameters in patients infected with HIV. This report considers interactions between these viral infections, the immune system, and antiretroviral therapy. A total of 130 male hemophiliac patients were grouped according to type of viremia (HCV, HIV, both, or neither). Along with 30 healthy men age-matched to viremic patients, these groups were compared with respect to viral load and immunologic parameters. Thirty-five patients treated as above for HIV were serially followed up. HCV infection was associated with reduced peripheral B-cell and CD4(+)-cell counts and with increased serum IgG and IgM levels, whereas HIV infection was associated with reduced peripheral CD4(+)-cell counts and increased serum IgG and IgA levels. In patients with both viruses, HCV and HIV RNA load correlated inversely with peripheral B-cell and CD4(+)-cell counts, respectively. HAART reduced levels of both viruses in the blood. Of the 25 patients with both viruses, HAART eliminated HCV in 2. In conclusion, immunologic dynamics differed between hemophiliac patients infected with HCV, HIV, or both. The relative dynamics of HCV viral load, peripheral B-cell count, and serum IgM level were similar to those of HIV viral load, CD4(+)-cell count, and serum IgA. (Blood. 2000;96:4293-4299) SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/11110704/Immunologic_dynamics_in_hemophiliac_patients_infected_with_hepatitis_C_virus_and_human_immunodeficiency_virus:_influence_of_antiretroviral_therapy_ L2 - http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=11110704 DB - PRIME DP - Unbound Medicine ER -