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Regulation of toxin and virulence gene transcription in Bacillus thuringiensis.
Int J Med Microbiol. 2000 Oct; 290(4-5):295-9.IJ

Abstract

Bacillus thuringiensis is a spore-forming bacterium well known for its insecticidal properties and its ability to produce a crystal inclusion during sporulation. The specific activity of B. thuringiensis against insect larvae is due to the crystal proteins (Cry proteins). Two different transcriptional mechanisms (dependent and independent of sporulation) are responsible for cry gene transcription during the stationary phase. In addition to these specific insecticidal toxins, B. thuringiensis produces potential virulence factors including haemolysins, degradative enzymes and enterotoxins. A pleiotropic regulator (PlcR) that activates the transcription of various genes encoding such extracellular proteins has been identified. Its expression at the onset of the stationary phase is dependent on the growth medium and is controlled by the transition state regulator, SpoOA.

Authors+Show Affiliations

Unité de Biochimie Microbienne, Centre National de la Recherche Scientifique URA 2172, Institut Pasteur, Paris, France. lereclus@pasteur.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11111901

Citation

Lereclus, D, et al. "Regulation of Toxin and Virulence Gene Transcription in Bacillus Thuringiensis." International Journal of Medical Microbiology : IJMM, vol. 290, no. 4-5, 2000, pp. 295-9.
Lereclus D, Agaisse H, Grandvalet C, et al. Regulation of toxin and virulence gene transcription in Bacillus thuringiensis. Int J Med Microbiol. 2000;290(4-5):295-9.
Lereclus, D., Agaisse, H., Grandvalet, C., Salamitou, S., & Gominet, M. (2000). Regulation of toxin and virulence gene transcription in Bacillus thuringiensis. International Journal of Medical Microbiology : IJMM, 290(4-5), 295-9.
Lereclus D, et al. Regulation of Toxin and Virulence Gene Transcription in Bacillus Thuringiensis. Int J Med Microbiol. 2000;290(4-5):295-9. PubMed PMID: 11111901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of toxin and virulence gene transcription in Bacillus thuringiensis. AU - Lereclus,D, AU - Agaisse,H, AU - Grandvalet,C, AU - Salamitou,S, AU - Gominet,M, PY - 2000/12/9/pubmed PY - 2001/5/5/medline PY - 2000/12/9/entrez SP - 295 EP - 9 JF - International journal of medical microbiology : IJMM JO - Int. J. Med. Microbiol. VL - 290 IS - 4-5 N2 - Bacillus thuringiensis is a spore-forming bacterium well known for its insecticidal properties and its ability to produce a crystal inclusion during sporulation. The specific activity of B. thuringiensis against insect larvae is due to the crystal proteins (Cry proteins). Two different transcriptional mechanisms (dependent and independent of sporulation) are responsible for cry gene transcription during the stationary phase. In addition to these specific insecticidal toxins, B. thuringiensis produces potential virulence factors including haemolysins, degradative enzymes and enterotoxins. A pleiotropic regulator (PlcR) that activates the transcription of various genes encoding such extracellular proteins has been identified. Its expression at the onset of the stationary phase is dependent on the growth medium and is controlled by the transition state regulator, SpoOA. SN - 1438-4221 UR - https://www.unboundmedicine.com/medline/citation/11111901/Regulation_of_toxin_and_virulence_gene_transcription_in_Bacillus_thuringiensis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1438-4221(00)80024-7 DB - PRIME DP - Unbound Medicine ER -