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Rapid determination of ethylene glycol and glycolic acid in biological fluids.
Vet Hum Toxicol. 2000 Dec; 42(6):358-60.VH

Abstract

Ethylene glycol poisoning of companion animals is a common occurrence and is sometimes involved in human intoxication. Ethylene glycol is of limited toxicity, but the metabolites including glycolic acid are responsible for poisoning. Conventional treatment has employed substances to prevent alcohol dehydrogenase from metabolizing the ethylene glycol, but to be effective, therapy must begin within hours of ethylene glycol consumption. We describe a rapid (10 min) analysis of biological fluids for ethylene glycol and glycolic acid using isocratic HPLC, a refractive index detector, and a Waters fast fruit juice analytical column.

Authors+Show Affiliations

Livestock Disease Diagnostic Center, Department of Veterinary Science, University of Kentucky, Lexington 40511, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11111945

Citation

Smith, R A., and D G. Lang. "Rapid Determination of Ethylene Glycol and Glycolic Acid in Biological Fluids." Veterinary and Human Toxicology, vol. 42, no. 6, 2000, pp. 358-60.
Smith RA, Lang DG. Rapid determination of ethylene glycol and glycolic acid in biological fluids. Vet Hum Toxicol. 2000;42(6):358-60.
Smith, R. A., & Lang, D. G. (2000). Rapid determination of ethylene glycol and glycolic acid in biological fluids. Veterinary and Human Toxicology, 42(6), 358-60.
Smith RA, Lang DG. Rapid Determination of Ethylene Glycol and Glycolic Acid in Biological Fluids. Vet Hum Toxicol. 2000;42(6):358-60. PubMed PMID: 11111945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid determination of ethylene glycol and glycolic acid in biological fluids. AU - Smith,R A, AU - Lang,D G, PY - 2000/12/9/pubmed PY - 2001/4/21/medline PY - 2000/12/9/entrez SP - 358 EP - 60 JF - Veterinary and human toxicology JO - Vet Hum Toxicol VL - 42 IS - 6 N2 - Ethylene glycol poisoning of companion animals is a common occurrence and is sometimes involved in human intoxication. Ethylene glycol is of limited toxicity, but the metabolites including glycolic acid are responsible for poisoning. Conventional treatment has employed substances to prevent alcohol dehydrogenase from metabolizing the ethylene glycol, but to be effective, therapy must begin within hours of ethylene glycol consumption. We describe a rapid (10 min) analysis of biological fluids for ethylene glycol and glycolic acid using isocratic HPLC, a refractive index detector, and a Waters fast fruit juice analytical column. SN - 0145-6296 UR - https://www.unboundmedicine.com/medline/citation/11111945/Rapid_determination_of_ethylene_glycol_and_glycolic_acid_in_biological_fluids_ DB - PRIME DP - Unbound Medicine ER -