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The cytosporones, new octaketide antibiotics isolated from an endophytic fungus.
Org Lett. 2000 Dec 14; 2(25):4043-6.OL

Abstract

[structure] Organic extracts from cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antibiotic activity. Two endophytes CR200 (Cytospora sp.) and CR146 (Diaporthe sp.) were found to have potent antibiotic activity. Bioassay-guided fractionation of the extracts from these fungi led to the identification of cytosporones D and E, antibacterial active trihydroxybenzene lactones, and three related but inactive metabolites. The five new octaketides were characterized using X-ray crystallography and NMR.

Authors+Show Affiliations

Brady SF
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
Wagenaar MM
No affiliation info available
Singh MP
No affiliation info available
Janso JE
No affiliation info available
Clardy J
No affiliation info available

MeSH

Anti-Bacterial AgentsAntifungal AgentsBacteriaBenzopyransCrystallography, X-RayFermentationLactonesMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMitosporic FungiModels, Molecular

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11112639

Citation

Brady, S F., et al. "The Cytosporones, New Octaketide Antibiotics Isolated From an Endophytic Fungus." Organic Letters, vol. 2, no. 25, 2000, pp. 4043-6.
Brady SF, Wagenaar MM, Singh MP, et al. The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Org Lett. 2000;2(25):4043-6.
Brady, S. F., Wagenaar, M. M., Singh, M. P., Janso, J. E., & Clardy, J. (2000). The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Organic Letters, 2(25), 4043-6.
Brady SF, et al. The Cytosporones, New Octaketide Antibiotics Isolated From an Endophytic Fungus. Org Lett. 2000 Dec 14;2(25):4043-6. PubMed PMID: 11112639.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. AU - Brady,S F, AU - Wagenaar,M M, AU - Singh,M P, AU - Janso,J E, AU - Clardy,J, PY - 2000/12/12/pubmed PY - 2001/3/3/medline PY - 2000/12/12/entrez SP - 4043 EP - 6 JF - Organic letters JO - Org Lett VL - 2 IS - 25 N2 - [structure] Organic extracts from cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antibiotic activity. Two endophytes CR200 (Cytospora sp.) and CR146 (Diaporthe sp.) were found to have potent antibiotic activity. Bioassay-guided fractionation of the extracts from these fungi led to the identification of cytosporones D and E, antibacterial active trihydroxybenzene lactones, and three related but inactive metabolites. The five new octaketides were characterized using X-ray crystallography and NMR. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/11112639/The_cytosporones_new_octaketide_antibiotics_isolated_from_an_endophytic_fungus_ DB - PRIME DP - Unbound Medicine ER -