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Vanilloid receptor 1-like receptor-immunoreactive primary sensory neurons in the rat trigeminal nervous system.
Neuroscience. 2000; 101(3):719-25.N

Abstract

Immunohistochemistry for vanilloid receptor 1-like receptor (VRL-1), a candidate transducer for high-threshold noxious heat, was performed on rat trigeminal primary sensory neurons. The immunoreactivity was detected in 14% of the trigeminal ganglion cell bodies, while the neurons in the mesencephalic trigeminal tract nucleus were almost devoid of it (0.5%). The immunoreactive neurons in the trigeminal ganglion were mostly of medium to large size (mean+/-S.D. of 956+/-376microm(2)). Nerve bundles in the tooth pulp, periodontal ligament, facial skin and oral mucosa contained VRL-1-positive smooth nerve fibers. The immunoreactivity could not be traced to the isolated nerve fibers, except in the tooth pulp. In the brainstem trigeminal nuclear complex, a notable concentration of the immunoreactivity was seen in laminae I and II of the medullary dorsal horn. Thirty-seven per cent of the trigeminal ganglion neurons retrogradely labeled from the tooth pulp exhibited VRL-1 immunoreactivity, while the immunoreactivity was detected in only 9% of those labeled from the skin. Co-expression of calcitonin gene-related peptide was common among the VRL-1-immunoreactive tooth pulp neurons (45%) and cutaneous neurons (25%). Moreover, as many as 41% of the VRL-1-immunoreactive tooth pulp neurons co-expressed parvalbumin immunoreactivity. Parvalbumin immunoreactivity was never detected in the VRL-1-immunoreactive cutaneous neurons. From the findings of the present study, we propose that large primary neurons responding to high-threshold noxious heat are abundant in the tooth pulp, but not in the facial skin.

Authors+Show Affiliations

Second Department of Oral Anatomy and Biodental Research Center, Okayama University Dental School, 2-5-1 Shikata-cho, 700-8525, Okayama, Japan. hiroichi@dent.okayama-u.ac.jpNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11113320

Citation

Ichikawa, H, and T Sugimoto. "Vanilloid Receptor 1-like Receptor-immunoreactive Primary Sensory Neurons in the Rat Trigeminal Nervous System." Neuroscience, vol. 101, no. 3, 2000, pp. 719-25.
Ichikawa H, Sugimoto T. Vanilloid receptor 1-like receptor-immunoreactive primary sensory neurons in the rat trigeminal nervous system. Neuroscience. 2000;101(3):719-25.
Ichikawa, H., & Sugimoto, T. (2000). Vanilloid receptor 1-like receptor-immunoreactive primary sensory neurons in the rat trigeminal nervous system. Neuroscience, 101(3), 719-25.
Ichikawa H, Sugimoto T. Vanilloid Receptor 1-like Receptor-immunoreactive Primary Sensory Neurons in the Rat Trigeminal Nervous System. Neuroscience. 2000;101(3):719-25. PubMed PMID: 11113320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vanilloid receptor 1-like receptor-immunoreactive primary sensory neurons in the rat trigeminal nervous system. AU - Ichikawa,H, AU - Sugimoto,T, PY - 2000/12/13/pubmed PY - 2001/3/7/medline PY - 2000/12/13/entrez SP - 719 EP - 25 JF - Neuroscience JO - Neuroscience VL - 101 IS - 3 N2 - Immunohistochemistry for vanilloid receptor 1-like receptor (VRL-1), a candidate transducer for high-threshold noxious heat, was performed on rat trigeminal primary sensory neurons. The immunoreactivity was detected in 14% of the trigeminal ganglion cell bodies, while the neurons in the mesencephalic trigeminal tract nucleus were almost devoid of it (0.5%). The immunoreactive neurons in the trigeminal ganglion were mostly of medium to large size (mean+/-S.D. of 956+/-376microm(2)). Nerve bundles in the tooth pulp, periodontal ligament, facial skin and oral mucosa contained VRL-1-positive smooth nerve fibers. The immunoreactivity could not be traced to the isolated nerve fibers, except in the tooth pulp. In the brainstem trigeminal nuclear complex, a notable concentration of the immunoreactivity was seen in laminae I and II of the medullary dorsal horn. Thirty-seven per cent of the trigeminal ganglion neurons retrogradely labeled from the tooth pulp exhibited VRL-1 immunoreactivity, while the immunoreactivity was detected in only 9% of those labeled from the skin. Co-expression of calcitonin gene-related peptide was common among the VRL-1-immunoreactive tooth pulp neurons (45%) and cutaneous neurons (25%). Moreover, as many as 41% of the VRL-1-immunoreactive tooth pulp neurons co-expressed parvalbumin immunoreactivity. Parvalbumin immunoreactivity was never detected in the VRL-1-immunoreactive cutaneous neurons. From the findings of the present study, we propose that large primary neurons responding to high-threshold noxious heat are abundant in the tooth pulp, but not in the facial skin. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/11113320/Vanilloid_receptor_1_like_receptor_immunoreactive_primary_sensory_neurons_in_the_rat_trigeminal_nervous_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(00)00427-9 DB - PRIME DP - Unbound Medicine ER -