Tags

Type your tag names separated by a space and hit enter

Hyperhomocyst(e)inemia, related vitamins and dementias.
J Nutr Health Aging. 2000; 4(4):195-6.JN

Abstract

Vitamin B12 and to a lesser extent folate deficiencies have been associated with dementias. Both these vitamins are determinants of plasma total homocysteine concentrations. In this review the frequency distributions of plasma vitamin B12, folate and homocysteine in South African males (# 51 yrs and > 51 yrs) illustrate the lower vitamin B12 levels in older subjects, and the shift toward elevated homocysteine concentrations in elderly people. Vitamin B12 deficiency appears to be associated with neuropsychiatric disorders, including dementias, but no causal relationship based on biochemical evidence has so far been established. Supplementation with vitamin B12 improves some neurological abnormalities and reverses only mild dementia of recent onset, but does not slow the progression of dementia. Elevated homocysteine levels appears to affect cognitive function, as measured by spatial copying skills and visual event-related potentials. Measurement of plasma homocysteine may help identify individuals with vitamin deficiencies and hyperhomocysteinemia. The relation between B-vitamins, homocysteine and dementia needs to explored further before vitamin supplementation is advocated to prevent or reverse neuropsychiatric disorders.

Authors+Show Affiliations

Department of Chemical Pathology, Faculty of Medicine, University of Pretoria, PO Box 2034, Pretoria 0001, South Africa. rdelport@medic.up.ac.za

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11115799

Citation

Delport, R. "Hyperhomocyst(e)inemia, Related Vitamins and Dementias." The Journal of Nutrition, Health & Aging, vol. 4, no. 4, 2000, pp. 195-6.
Delport R. Hyperhomocyst(e)inemia, related vitamins and dementias. J Nutr Health Aging. 2000;4(4):195-6.
Delport, R. (2000). Hyperhomocyst(e)inemia, related vitamins and dementias. The Journal of Nutrition, Health & Aging, 4(4), 195-6.
Delport R. Hyperhomocyst(e)inemia, Related Vitamins and Dementias. J Nutr Health Aging. 2000;4(4):195-6. PubMed PMID: 11115799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocyst(e)inemia, related vitamins and dementias. A1 - Delport,R, PY - 2000/12/15/pubmed PY - 2001/6/29/medline PY - 2000/12/15/entrez SP - 195 EP - 6 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 4 IS - 4 N2 - Vitamin B12 and to a lesser extent folate deficiencies have been associated with dementias. Both these vitamins are determinants of plasma total homocysteine concentrations. In this review the frequency distributions of plasma vitamin B12, folate and homocysteine in South African males (# 51 yrs and > 51 yrs) illustrate the lower vitamin B12 levels in older subjects, and the shift toward elevated homocysteine concentrations in elderly people. Vitamin B12 deficiency appears to be associated with neuropsychiatric disorders, including dementias, but no causal relationship based on biochemical evidence has so far been established. Supplementation with vitamin B12 improves some neurological abnormalities and reverses only mild dementia of recent onset, but does not slow the progression of dementia. Elevated homocysteine levels appears to affect cognitive function, as measured by spatial copying skills and visual event-related potentials. Measurement of plasma homocysteine may help identify individuals with vitamin deficiencies and hyperhomocysteinemia. The relation between B-vitamins, homocysteine and dementia needs to explored further before vitamin supplementation is advocated to prevent or reverse neuropsychiatric disorders. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/11115799/Hyperhomocyst_e_inemia_related_vitamins_and_dementias_ L2 - http://www.diseaseinfosearch.org/result/2184 DB - PRIME DP - Unbound Medicine ER -