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Fatty acid intake and the risk of dementia and cognitive decline: a review of clinical and epidemiological studies.

Abstract

Dietary intake of fatty acids may be related to dementia and cognitive function through a number of plausible mechanisms, such as atherosclerosis and thrombosis, inflammation, via an effect on brain development and membrane functioning, or via accumulation of beta-amyloid. This review gives an overview of the few studies that have investigated the relationship between fatty acid intake (including the fatty acids from fish) and cognitive function or dementia and summarises the results from two Dutch population-based prospective studies: the Zutphen Elderly Study (n=476) and the Rotterdam Study (n=5,386). Additionally, limitations on dietary intake studies are discussed and possible mechanisms behind the investigated associations. Data from the Rotterdam Study showed that high intakes of the following nutrients were associated with an increased risk of dementia after adjustment for confounders: total fat (RR=2.4 (95%CI: 1.1-5.2)), saturated fat (RR=1.9 (95%CI: 0.9-4.0)), and cholesterol (RR=1.7 (95%CI: 0.9-3.2)). A high fish consumption, an important source of n-3 PUFAs, reduced the risk of dementia (RR=0.4 (95%CI: 0.2-0.9)). In the Zutphen Elderly Study a high linoleic acid intake was associated with cognitive impairment (OR=1.8 (95%CI: 1.0-3.0)). A high fish consumption tended to be inversely associated with cognitive impairment and decline (RR=0.5, 95%CI: 0.2-1.2). Since diet is a risk factor that is suitable for intervention these results are hopeful and potentially very important.

Authors+Show Affiliations

Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. sandra.kalmijn@rivm.nl

Source

MeSH

Aged
Aging
Animals
Cardiovascular Diseases
Dementia
Dietary Fats
Fatty Acids
Female
Fishes
Humans
Longitudinal Studies
Male
Middle Aged
Netherlands
Prospective Studies
Risk Factors

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

11115801

Citation

Kalmijn, S. "Fatty Acid Intake and the Risk of Dementia and Cognitive Decline: a Review of Clinical and Epidemiological Studies." The Journal of Nutrition, Health & Aging, vol. 4, no. 4, 2000, pp. 202-7.
Kalmijn S. Fatty acid intake and the risk of dementia and cognitive decline: a review of clinical and epidemiological studies. J Nutr Health Aging. 2000;4(4):202-7.
Kalmijn, S. (2000). Fatty acid intake and the risk of dementia and cognitive decline: a review of clinical and epidemiological studies. The Journal of Nutrition, Health & Aging, 4(4), pp. 202-7.
Kalmijn S. Fatty Acid Intake and the Risk of Dementia and Cognitive Decline: a Review of Clinical and Epidemiological Studies. J Nutr Health Aging. 2000;4(4):202-7. PubMed PMID: 11115801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid intake and the risk of dementia and cognitive decline: a review of clinical and epidemiological studies. A1 - Kalmijn,S, PY - 2000/12/15/pubmed PY - 2001/6/29/medline PY - 2000/12/15/entrez SP - 202 EP - 7 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 4 IS - 4 N2 - Dietary intake of fatty acids may be related to dementia and cognitive function through a number of plausible mechanisms, such as atherosclerosis and thrombosis, inflammation, via an effect on brain development and membrane functioning, or via accumulation of beta-amyloid. This review gives an overview of the few studies that have investigated the relationship between fatty acid intake (including the fatty acids from fish) and cognitive function or dementia and summarises the results from two Dutch population-based prospective studies: the Zutphen Elderly Study (n=476) and the Rotterdam Study (n=5,386). Additionally, limitations on dietary intake studies are discussed and possible mechanisms behind the investigated associations. Data from the Rotterdam Study showed that high intakes of the following nutrients were associated with an increased risk of dementia after adjustment for confounders: total fat (RR=2.4 (95%CI: 1.1-5.2)), saturated fat (RR=1.9 (95%CI: 0.9-4.0)), and cholesterol (RR=1.7 (95%CI: 0.9-3.2)). A high fish consumption, an important source of n-3 PUFAs, reduced the risk of dementia (RR=0.4 (95%CI: 0.2-0.9)). In the Zutphen Elderly Study a high linoleic acid intake was associated with cognitive impairment (OR=1.8 (95%CI: 1.0-3.0)). A high fish consumption tended to be inversely associated with cognitive impairment and decline (RR=0.5, 95%CI: 0.2-1.2). Since diet is a risk factor that is suitable for intervention these results are hopeful and potentially very important. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/11115801/Fatty_acid_intake_and_the_risk_of_dementia_and_cognitive_decline:_a_review_of_clinical_and_epidemiological_studies_ L2 - https://medlineplus.gov/dementia.html DB - PRIME DP - Unbound Medicine ER -