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Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study: The Netherlands Cohort Study on Diet and Cancer.

Abstract

The relation between vegetable and fruit consumption and colorectal cancer risk was comprehensively assessed in the Netherlands Cohort Study on Diet and Cancer using a validated 150-item food frequency questionnaire. After 6.3 years of follow-up (1986-1992), over 1,000 incident cases of colorectal cancer were registered. Using case-cohort analysis, the authors calculated rate ratios and 95% confidence intervals adjusted for age, alcohol intake, and family history of colorectal cancer. For colon cancer, no statistically significant associations with total vegetable intake or total fruit intake were found. However, among women, an inverse association was observed with vegetables and fruits combined (for the highest quintile vs. the lowest, the rate ratio was 0.66 (95% confidence interval: 0.44, 1.01)). Brassica vegetables and cooked leafy vegetables showed inverse associations for both men and women. Among women and, to a lesser extent, among men, inverse associations were stronger for distal colonic tumors than for proximal colonic tumors. For rectal cancer, no statistically significant associations were found for vegetable consumption or fruit consumption or for specific groups of vegetables and fruits; only Brassica vegetables showed a positive association in women. As in other cohort studies, the observed inverse relation between vegetable and fruit consumption and occurrence of colorectal cancer was less strong than relations reported in case-control studies.

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  • Authors+Show Affiliations

    ,

    Department of Nutritional Epidemiology, TNO Nutrition and Food Research, Zeist, The Netherlands. Voorrips@voeding.tno.nl

    , , , ,

    Source

    American journal of epidemiology 152:11 2000 Dec 01 pg 1081-92

    MeSH

    Age Distribution
    Aged
    Case-Control Studies
    Colonic Neoplasms
    Feeding Behavior
    Female
    Fruit
    Humans
    Incidence
    Likelihood Functions
    Male
    Middle Aged
    Multivariate Analysis
    Netherlands
    Prospective Studies
    Rectal Neoplasms
    Sex Distribution
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11117618

    Citation

    Voorrips, L E., et al. "Vegetable and Fruit Consumption and Risks of Colon and Rectal Cancer in a Prospective Cohort Study: the Netherlands Cohort Study On Diet and Cancer." American Journal of Epidemiology, vol. 152, no. 11, 2000, pp. 1081-92.
    Voorrips LE, Goldbohm RA, van Poppel G, et al. Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study: The Netherlands Cohort Study on Diet and Cancer. Am J Epidemiol. 2000;152(11):1081-92.
    Voorrips, L. E., Goldbohm, R. A., van Poppel, G., Sturmans, F., Hermus, R. J., & van den Brandt, P. A. (2000). Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study: The Netherlands Cohort Study on Diet and Cancer. American Journal of Epidemiology, 152(11), pp. 1081-92.
    Voorrips LE, et al. Vegetable and Fruit Consumption and Risks of Colon and Rectal Cancer in a Prospective Cohort Study: the Netherlands Cohort Study On Diet and Cancer. Am J Epidemiol. 2000 Dec 1;152(11):1081-92. PubMed PMID: 11117618.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study: The Netherlands Cohort Study on Diet and Cancer. AU - Voorrips,L E, AU - Goldbohm,R A, AU - van Poppel,G, AU - Sturmans,F, AU - Hermus,R J, AU - van den Brandt,P A, PY - 2000/12/16/pubmed PY - 2001/2/28/medline PY - 2000/12/16/entrez SP - 1081 EP - 92 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 152 IS - 11 N2 - The relation between vegetable and fruit consumption and colorectal cancer risk was comprehensively assessed in the Netherlands Cohort Study on Diet and Cancer using a validated 150-item food frequency questionnaire. After 6.3 years of follow-up (1986-1992), over 1,000 incident cases of colorectal cancer were registered. Using case-cohort analysis, the authors calculated rate ratios and 95% confidence intervals adjusted for age, alcohol intake, and family history of colorectal cancer. For colon cancer, no statistically significant associations with total vegetable intake or total fruit intake were found. However, among women, an inverse association was observed with vegetables and fruits combined (for the highest quintile vs. the lowest, the rate ratio was 0.66 (95% confidence interval: 0.44, 1.01)). Brassica vegetables and cooked leafy vegetables showed inverse associations for both men and women. Among women and, to a lesser extent, among men, inverse associations were stronger for distal colonic tumors than for proximal colonic tumors. For rectal cancer, no statistically significant associations were found for vegetable consumption or fruit consumption or for specific groups of vegetables and fruits; only Brassica vegetables showed a positive association in women. As in other cohort studies, the observed inverse relation between vegetable and fruit consumption and occurrence of colorectal cancer was less strong than relations reported in case-control studies. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/11117618/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/152.11.1081 DB - PRIME DP - Unbound Medicine ER -